STRINGSTRING
CC_0109 CC_0109 dnaQ dnaQ rpsT rpsT dnaA dnaA rpsO rpsO infB infB CC_0119 CC_0119 recF recF CC_0268 CC_0268 parB parB nth nth CC_3718 CC_3718 CC_3711 CC_3711 CC_3683 CC_3683 rpsP rpsP hpf hpf RpsA RpsA ihfB ihfB CC_3563 CC_3563 amgK amgK cobB cobB CC_3465 CC_3465 CC_3456 CC_3456 CC_3441 CC_3441 CC_3418 CC_3418 rpmJ rpmJ rpsU rpsU rpmE rpmE CC_3231 CC_3231 cpoB cpoB rpsG rpsG CC_3121 CC_3121 CC_3092 CC_3092 dnaG dnaG CC_3021 CC_3021 CC_2965 CC_2965 CC_2938 CC_2938 CC_2868 CC_2868 CC_2818 CC_2818 CC_2779 CC_2779 ftsZ ftsZ rpsD rpsD CC_2469 CC_2469 rpmG rpmG CC_2448 CC_2448 hfsA hfsA cutC cutC CC_2331 CC_2331 CC_2272 CC_2272 CC_2058 CC_2058 edd edd CC_2031 CC_2031 CC_1983 CC_1983 hup hup rpsB rpsB CC_1863 CC_1863 CC_1848 CC_1848 CC_1847 CC_1847 rpmF rpmF CC_1711 CC_1711 rpsF rpsF rpsR rpsR rplI rplI CC_1665 CC_1665 guaB guaB recO recO CC_1523 CC_1523 CC_1514 CC_1514 flbA flbA rpsI rpsI rplM rplM ihfA ihfA CC_1356 CC_1356 CC_1283 CC_1283 rplQ rplQ rpsK rpsK rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ CC_1201 CC_1201 CC_1115 CC_1115 CC_1107 CC_1107 CC_1068 CC_1068 rpmI rpmI CC_0949 CC_0949 CC_0933 CC_0933 CC_0835 CC_0835 CC_0771 CC_0771 rpmH rpmH CC_0729 CC_0729 rpmB rpmB CC_0632 CC_0632 CC_0631 CC_0631 CC_0622 CC_0622 CC_0601 CC_0601 CC_0557 CC_0557 CC_0498 CC_0498 rplL rplL rplJ rplJ rplY rplY CC_0483 CC_0483 CC_0401 CC_0401 ccrMIM ccrMIM smc smc priA priA rplU rplU rpmA rpmA recR recR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CC_0109ATP-dependent protease La domain protein; Identified by match to PFAM protein family HMM PF02190. (225 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (237 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (91 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (490 aa)
rpsORibosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (1037 aa)
CC_0119TPR domain protein; Identified by match to protein family HMM. (747 aa)
recFrecF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). (387 aa)
CC_0268Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (102 aa)
parBChromosome partitioning protein ParB; Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication; Belongs to the ParB family. (294 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (241 aa)
CC_3718TPR domain protein; Identified by match to protein family HMM. (596 aa)
CC_3711Hypothetical protein; Identified by Glimmer2; putative. (168 aa)
CC_3683Hypothetical protein; Identified by Glimmer2; putative. (143 aa)
rpsPRibosomal protein S16; Identified by match to TIGR protein family HMM TIGR00002; Belongs to the bacterial ribosomal protein bS16 family. (165 aa)
hpfRibosomal subunit interface protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (208 aa)
RpsARibosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (565 aa)
ihfBIntegration host factor beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (96 aa)
CC_3563Conserved hypothetical protein; Identified by Glimmer2; putative. (231 aa)
amgKConserved hypothetical protein; Sugar kinase that catalyzes the ATP-dependent phosphorylation of N-acetylmuramate (MurNAc) and N-acetylglucosamine (GlcNAc) at its C1 hydroxyl group, leading to MurNAc alpha-1P and GlcNAc alpha-1P, respectively (By similarity). Is likely involved in peptidoglycan recycling as part of a cell wall recycling pathway that bypasses de novo biosynthesis of the peptidoglycan precursor UDP-MurNAc. Is able to complement the fosfomycin sensitivity phenotype of a P.putida mutant lacking amgK. (363 aa)
cobBTranscriptional regulator, Sir2 family; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. (238 aa)
CC_3465ATP-dependent DNA helicase RecQ; Identified by match to protein family HMM. (615 aa)
CC_3456Conserved hypothetical protein; Identified by Glimmer2; putative. (306 aa)
CC_3441Identified by match to protein family HMM. (438 aa)
CC_3418Conserved hypothetical protein; Identified by Glimmer2; putative. (504 aa)
rpmJRibosomal protein L36; Identified by match to protein family HMM; Belongs to the bacterial ribosomal protein bL36 family. (41 aa)
rpsURibosomal protein S21; Identified by match to TIGR protein family HMM TIGR00030; Belongs to the bacterial ribosomal protein bS21 family. (87 aa)
rpmERibosomal protein L31; Binds the 23S rRNA; Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily. (76 aa)
CC_3231Hypothetical protein; Identified by Glimmer2; putative. (270 aa)
cpoBHypothetical protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (284 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (157 aa)
CC_3121Phytoene dehydrogenase-related protein; Identified by match to PFAM protein family HMM PF02032. (543 aa)
CC_3092Hypothetical protein; Identified by Glimmer2; putative. (134 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (643 aa)
CC_3021Cobalamin biosynthesis protein; Similar to GB:M62869 SP:P29933 PID:151168 PID:1926457; identified by sequence similarity; putative. (336 aa)
CC_2965Hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0339 family. (59 aa)
CC_2938TPR domain protein; Identified by match to protein family HMM. (295 aa)
CC_2868neuB protein, putative; Similar to GB:U05248 PID:454081; identified by sequence similarity; putative. (356 aa)
CC_2818TPR domain protein; Identified by match to protein family HMM. (526 aa)
CC_2779Hypothetical protein; Identified by Glimmer2; putative. (168 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (508 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (205 aa)
CC_2469Hypothetical protein; Identified by Glimmer2; putative. (122 aa)
rpmGRibosomal protein L33; Identified by match to protein family HMM; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
CC_2448Conserved hypothetical protein; Identified by Glimmer2; putative. (401 aa)
hfsAHfsA; Identified by Glimmer2; putative. (501 aa)
cutCConserved hypothetical protein; Participates in the control of copper homeostasis. Belongs to the CutC family. (245 aa)
CC_2331DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (92 aa)
CC_2272Identified by match to protein family HMM. (241 aa)
CC_2058Hypothetical protein; Identified by Glimmer2; putative. (958 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (602 aa)
CC_2031TPR domain protein; Identified by match to protein family HMM. (184 aa)
CC_1983DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (568 aa)
hupDNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (92 aa)
rpsBRibosomal protein S2; Identified by match to protein family HMM; Belongs to the universal ribosomal protein uS2 family. (268 aa)
CC_1863Hypothetical protein; Identified by Glimmer2; putative. (129 aa)
CC_1848Hypothetical protein; Identified by Glimmer2; putative. (383 aa)
CC_1847ATP-dependent RNA helicase, DEAD/DEAH box family; Identified by match to protein family HMM; Belongs to the DEAD box helicase family. (517 aa)
rpmFRibosomal protein L32; Identified by match to protein family HMM; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
CC_1711DnaA-related protein; Similar to SP:P35887 GB:U01667 PID:403535; identified by sequence similarity; putative. (230 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (126 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (92 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (194 aa)
CC_1665Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (507 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
recOConserved hypothetical protein; Involved in DNA repair and RecF pathway recombination. (250 aa)
CC_1523Exonuclease; Identified by match to PFAM protein family HMM PF00929. (202 aa)
CC_1514Hypothetical protein; Identified by Glimmer2; putative. (99 aa)
flbAFlagellin modification protein FlmG; Identified by match to protein family HMM. (596 aa)
rpsIRibosomal protein S9; Identified by match to protein family HMM; Belongs to the universal ribosomal protein uS9 family. (157 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (157 aa)
ihfAIntegration host factor alpha-subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (100 aa)
CC_1356Transcriptional regulator; Similar to PID:642657 SP:P55323; identified by sequence similarity; putative. (171 aa)
CC_1283ATPase, AAA family; Identified by match to protein family HMM. (433 aa)
rplQRibosomal protein L17; Identified by match to TIGR protein family HMM TIGR00059. (137 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (161 aa)
rpmDRibosomal protein L30; Identified by match to protein family HMM. (61 aa)
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (201 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (116 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsNRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (185 aa)
rplXRibosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (104 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (79 aa)
rpmCRibosomal protein L29; Identified by match to TIGR protein family HMM TIGR00012; Belongs to the universal ribosomal protein uL29 family. (63 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (143 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (250 aa)
rplVRibosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (126 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (279 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (98 aa)
rplDRibosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (212 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (267 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
CC_1201Class II aldolase/adducin domain protein; Identified by match to protein family HMM. (300 aa)
CC_1115Conserved hypothetical protein; Identified by Glimmer2; putative. (280 aa)
CC_1107TPR domain protein; Identified by match to protein family HMM. (672 aa)
CC_1068Hypothetical protein; Identified by Glimmer2; putative. (504 aa)
rpmIRibosomal protein L35; Identified by match to TIGR protein family HMM TIGR00001; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
CC_0949Transcriptional regulator; Similar to GB:M65201 GB:X82941 PID:142275 PID:599613 SP:P55324; identified by sequence similarity; putative. (181 aa)
CC_0933Transcriptional regulator; Similar to GB:M65201 GB:X82941 PID:142275 PID:599613 SP:P55324; identified by sequence similarity; putative. (191 aa)
CC_0835ATP-dependent RNA helicase, DEAD/DEAH box family; Identified by match to protein family HMM. (476 aa)
CC_0771Esterase, putative; Similar to PID:2088525; identified by sequence similarity; putative. (380 aa)
rpmHRibosomal protein L34; Identified by match to protein family HMM; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
CC_0729Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa)
rpmBRibosomal protein L28; Identified by match to TIGR protein family HMM TIGR00009; Belongs to the bacterial ribosomal protein bL28 family. (99 aa)
CC_0632Hypothetical protein; Identified by Glimmer2; putative. (350 aa)
CC_0631Hypothetical protein; Identified by Glimmer2; putative. (394 aa)
CC_0622Hypothetical protein; Identified by Glimmer2; putative. (347 aa)
CC_0601Hypothetical protein; Identified by Glimmer2; putative. (1004 aa)
CC_0557Hypothetical protein; Identified by Glimmer2; putative. (316 aa)
CC_0498Hypothetical protein; Identified by Glimmer2; putative. (296 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (172 aa)
rplYRibosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (197 aa)
CC_0483Hypothetical protein; Identified by Glimmer2; putative. (249 aa)
CC_0401Hypothetical protein; Identified by Glimmer2; putative. (127 aa)
ccrMIMModification methylase CcrMI; This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. Ccrm-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology; Belongs to the N(4)/N(6)-methyltransferase family. (358 aa)
smcSmc protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1147 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (719 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (171 aa)
rpmARibosomal protein L27; Identified by match to TIGR protein family HMM TIGR00062; Belongs to the bacterial ribosomal protein bL27 family. (89 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (152 aa)
Your Current Organism:
Caulobacter vibrioides CB15
NCBI taxonomy Id: 190650
Other names: C. vibrioides CB15, Caulobacter crescentus CB15, Caulobacter vibrioides ATCC 19089
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