(16 nodes) (2015) Topological control of the Caulobacter cell cycle circuitry by a polarized single-domain PAS protein. network (Caulobacter vibrioides CB15)

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Your Input:
	CC_0355	Hydrolase, putative; Identified by match to protein family HMM. (296 aa)
	dnaA	Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (490 aa)
	ctrA	Cell cycle transcriptional regulator CtrA; Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and class II flagellar biogenesis. (231 aa)
	pleC	Non-motile and phage-resistance protein; Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator PleD, leading to its activation. (842 aa)
	spmX	Identified by match to protein family HMM. (431 aa)
	clpP	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (210 aa)
	clpX	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (420 aa)
	dnaG	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (643 aa)
	CC_3308	Hydrolase, putative; Identified by match to protein family HMM. (307 aa)
	divL	Tyrosine kinase DivL; Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter. (769 aa)
	fljK	Flagellin FljK; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (273 aa)
	popZ	Hypothetical protein; Identified by Glimmer2; putative. (177 aa)
	divJ	Sensor histidine kinase DivJ; Kinase required for the regulation of cell division and differentiation. Is part of a signal transduction pathway, activating PleD by phosphorylation. (597 aa)
	flbD	Transcriptional regulator FlbD; Activation of sigma-54-dependent flagellar gene promoters and strong negative autoregulatory effects on its own promoter. The synthesis and function of FlbD in C.crescentus is controlled by an internal cell-cycle clock. (455 aa)
	fljM	Flagellin FljM; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (273 aa)
	cpdR	CpdR. (118 aa)

Your Current Organism:

Caulobacter vibrioides CB15

NCBI taxonomy Id: 190650
Other names: C. vibrioides CB15, Caulobacter crescentus CB15, Caulobacter vibrioides ATCC 19089

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
clpP	clpX	CC_1963	CC_1961	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.999
clpP	cpdR	CC_1963	CC_0744	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	CpdR.	0.986
clpP	ctrA	CC_1963	CC_3035	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Cell cycle transcriptional regulator CtrA; Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and class II flagellar biogenesis.	0.742
clpP	divJ	CC_1963	CC_1063	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Sensor histidine kinase DivJ; Kinase required for the regulation of cell division and differentiation. Is part of a signal transduction pathway, activating PleD by phosphorylation.	0.442
clpP	dnaA	CC_1963	CC_0008	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).	0.798
clpP	pleC	CC_1963	CC_2482	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Non-motile and phage-resistance protein; Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator PleD, leading to its activation.	0.402
clpX	clpP	CC_1961	CC_1963	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.999
clpX	cpdR	CC_1961	CC_0744	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	CpdR.	0.993
clpX	ctrA	CC_1961	CC_3035	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	Cell cycle transcriptional regulator CtrA; Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and class II flagellar biogenesis.	0.867
clpX	divJ	CC_1961	CC_1063	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	Sensor histidine kinase DivJ; Kinase required for the regulation of cell division and differentiation. Is part of a signal transduction pathway, activating PleD by phosphorylation.	0.485
clpX	dnaA	CC_1961	CC_0008	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).	0.763
clpX	pleC	CC_1961	CC_2482	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	Non-motile and phage-resistance protein; Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator PleD, leading to its activation.	0.553
cpdR	clpP	CC_0744	CC_1963	CpdR.	ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.986
cpdR	clpX	CC_0744	CC_1961	CpdR.	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.993
cpdR	ctrA	CC_0744	CC_3035	CpdR.	Cell cycle transcriptional regulator CtrA; Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and class II flagellar biogenesis.	0.457
cpdR	divJ	CC_0744	CC_1063	CpdR.	Sensor histidine kinase DivJ; Kinase required for the regulation of cell division and differentiation. Is part of a signal transduction pathway, activating PleD by phosphorylation.	0.939
cpdR	divL	CC_0744	CC_3484	CpdR.	Tyrosine kinase DivL; Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter.	0.931
cpdR	dnaA	CC_0744	CC_0008	CpdR.	Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).	0.649
cpdR	pleC	CC_0744	CC_2482	CpdR.	Non-motile and phage-resistance protein; Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator PleD, leading to its activation.	0.937
cpdR	popZ	CC_0744	CC_1319	CpdR.	Hypothetical protein; Identified by Glimmer2; putative.	0.591