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| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (285 aa) |
| | CC_0050 | S-adenosylmethionine synthetase; Identified by match to protein family HMM; Belongs to the AdoMet synthase family. (407 aa) |
| | CC_0101 | Ribulose-phosphate 3-epimerase; Identified by match to PFAM protein family HMM PF00834; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa) |
| | argG | Argininosuccinate synthase; Identified by match to TIGR protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (350 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (479 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (386 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Identified by match to protein family HMM; Belongs to the transferase hexapeptide repeat family. (283 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (304 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (377 aa) |
| | CC_0393 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. (512 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (139 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (777 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (260 aa) |
| | metXA | Homoserine O-acetyltransferase, putative; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (382 aa) |
| | argD1 | Succinylornithine transaminase, putative; Identified by match to protein family HMM; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (392 aa) |
| | CC_0843 | Aspartokinase; Identified by match to TIGR protein family HMM TIGR00656; Belongs to the aspartokinase family. (415 aa) |
| | CC_1071 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. (409 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (317 aa) |
| | CC_1383 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. (429 aa) |
| | CC_1397 | Phospho-2-dehydro-3-deoxyheptonate aldolase, class I; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (369 aa) |
| | CC_1421 | Dehydratase, IlvD/Edd family; Identified by match to PFAM protein family HMM PF00920; Belongs to the IlvD/Edd family. (600 aa) |
| | CC_1424 | Cystathionine beta-lyase; Identified by match to PFAM protein family HMM PF01053. (386 aa) |
| | CC_1426 | Cysteine synthase; Identified by match to protein family HMM. (332 aa) |
| | CC_1534 | Aspartate aminotransferase; Identified by match to protein family HMM. (400 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa) |
| | phhA | Phenylalanine-4-hydroxylase; Identified by match to protein family HMM. (294 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (513 aa) |
| | CC_1897 | Glutamine amidotransferase, class I; Identified by match to protein family HMM. (198 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Identified by match to protein family HMM; Belongs to the TrpC family. (262 aa) |
| | CC_1906 | Citrate synthase; Identified by match to protein family HMM; Belongs to the citrate synthase family. (426 aa) |
| | CC_1969 | Glutamine synthetase, class I; Identified by match to TIGR protein family HMM TIGR00653. (469 aa) |
| | CC_2051 | Pyruvate kinase; Identified by match to protein family HMM; Belongs to the pyruvate kinase family. (476 aa) |
| | CC_2097 | Phosphoserine phosphatase; Identified by match to TIGR protein family HMM TIGR00338. (296 aa) |
| | CC_2100 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. (582 aa) |
| | IlvH | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. (185 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | CC_2137 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (899 aa) |
| | CC_2138 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Similar to SP:P37586 GB:X52093; identified by sequence similarity; putative. (358 aa) |
| | argH | Argininosuccinate lyase; Identified by match to TIGR protein family HMM TIGR00838. (442 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | CC_2224 | Cyclohexadienyl dehydrogenase; Identified by match to PFAM protein family HMM PF02153. (312 aa) |
| | argF | Ornithine carbamoyltransferase, anabolic; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (311 aa) |
| | argD2 | Acetylornithine aminotransferase; Identified by match to protein family HMM; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (237 aa) |
| | CC_2266 | Identified by match to PFAM protein family HMM PF01048. (299 aa) |
| | CC_2300 | Phospho-2-dehydro-3-deoxyheptonate aldolase, class II; Identified by match to PFAM protein family HMM PF01474. (459 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (227 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa) |
| | CC_2522 | Isocitrate dehydrogenase, NADP-dependent; Identified by match to TIGR protein family HMM TIGR00127; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa) |
| | hisC2 | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (378 aa) |
| | CC_2651 | Serine acetyltransferase; Identified by match to protein family HMM. (279 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (296 aa) |
| | CC_2933 | Prephenate dehydratase; Identified by match to PFAM protein family HMM PF00800. (283 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (200 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (370 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Identified by match to TIGR protein family HMM TIGR00110. (617 aa) |
| | argJ | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (403 aa) |
| | CC_3093 | Threonine aldolase, low-specificity; Similar to GP:2865134; identified by sequence similarity; putative. (343 aa) |
| | CC_3105 | Threonine dehydratase; Identified by match to protein family HMM. (325 aa) |
| | CC_3108 | L-serine dehydratase; Identified by match to TIGR protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. (462 aa) |
| | CC_3130 | Identified by match to protein family HMM; Belongs to the glutamine synthetase family. (465 aa) |
| | CC_3138 | Identified by match to protein family HMM; Belongs to the glutamine synthetase family. (460 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (372 aa) |
| | CC_3204 | Hydrolase, alpha/beta hydrolase fold family; Identified by match to protein family HMM; Belongs to the AB hydrolase superfamily. MetX family. (358 aa) |
| | CC_3215 | D-3-phosphoglycerate dehydrogenase; Identified by match to PFAM protein family HMM PF00389; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa) |
| | CC_3216 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (396 aa) |
| | CC_3248 | Glyceraldehyde 3-phosphate dehydrogenase; Identified by match to protein family HMM; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | pgk | Phosphoglycerate kinase; Identified by match to protein family HMM; Belongs to the phosphoglycerate kinase family. (396 aa) |
| | CC_3250 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (363 aa) |
| | thrB | Homoserine kinase; Similar to GP:6647291; identified by sequence similarity; putative; Belongs to the pseudomonas-type ThrB family. (317 aa) |
| | CC_3399 | Threonine synthase; Identified by match to TIGR protein family HMM TIGR00260. (465 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (413 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (320 aa) |
| | HisZ | Hypothetical protein; Identified by Glimmer2; putative. (386 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (275 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | trpF | N-(5'-phosphoribosyl)-anthranilate isomerase; Identified by match to protein family HMM; Belongs to the TrpF family. (219 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (257 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (443 aa) |
| | CC_3606 | Glutamate synthase, small subunit; Identified by match to protein family HMM. (481 aa) |
| | CC_3607 | Glutamate synthase, large subunit; Identified by match to PFAM protein family HMM PF01645. (1508 aa) |
| | tal | Transaldolase family protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | CC_3620 | Identified by match to TIGR protein family HMM TIGR00232; Belongs to the transketolase family. (653 aa) |
| | CC_3625 | Cysteine synthase; Identified by match to protein family HMM. (328 aa) |
| | CC_3631 | Acetylornithine deacetylase; Identified by match to protein family HMM. (391 aa) |
| | CC_3635 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (400 aa) |
| | CC_3642 | Citrate synthase; Identified by match to protein family HMM; Belongs to the citrate synthase family. (361 aa) |
| | CC_3643 | Citrate synthase; Identified by match to protein family HMM. (388 aa) |
| | CC_3667 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (288 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475. (196 aa) |
| | hisH | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (213 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. (241 aa) |
| | hisF | hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (260 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503. (107 aa) |
