STRINGSTRING
AIR96140.1 AIR96140.1 AIR96212.1 AIR96212.1 AIR96563.1 AIR96563.1 cysD cysD metX metX AIR96772.1 AIR96772.1 AIR97054.1 AIR97054.1 gcvP gcvP metK metK AIR97278.1 AIR97278.1 metH metH AIR97440.1 AIR97440.1 asd1 asd1 serB serB araC araC dapA1 dapA1 dapD dapD metF metF leuA leuA asd2 asd2 AIR98520.1 AIR98520.1 ahcY ahcY AIR98782.1 AIR98782.1 cbs cbs purU purU serC serC AIR99068.1 AIR99068.1 vdh vdh cysA cysA dapC dapC ask ask asd asd ilvD ilvD folD2 folD2 glyA1 glyA1 metB metB AIS00224.1 AIS00224.1 alaA alaA lysA lysA hom hom thrC thrC thrB thrB glyA2 glyA2 sdaA sdaA glyA3 glyA3 gcvH gcvH gcvT gcvT AIS00667.1 AIS00667.1 AIS00681.1 AIS00681.1 ilvB ilvB ilvH ilvH ilvC ilvC serA serA leuB leuB ilvE ilvE AIS00701.1 AIS00701.1 leuC leuC leuD leuD dapB dapB dapA2 dapA2 dapF dapF AIS01221.1 AIS01221.1 AIS01291.1 AIS01291.1 AIS01812.1 AIS01812.1 folD1 folD1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AIR96140.1Dihydrodipicolinate synthetase; Belongs to the DapA family. (312 aa)
AIR96212.1Hypothetical protein. (337 aa)
AIR96563.1Threonine dehydratase. (322 aa)
cysDO-acetylhomoserine (thiol)-lyase. (453 aa)
metXHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (361 aa)
AIR96772.1Cysteine synthase B. (380 aa)
AIR97054.1Cystathionine gamma-synthase. (381 aa)
gcvPGlycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
AIR97278.1Aminotransferase. (273 aa)
metHMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1170 aa)
AIR97440.1Putative aspartate kinase. (366 aa)
asd1Putative Aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (347 aa)
serBPhosphoserine phosphatase. (402 aa)
araCL-arabonate dehydratase; Belongs to the IlvD/Edd family. (574 aa)
dapA14-hydroxy-tetrahydrodipicolinate synthase 1; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (333 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (307 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
asd2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
AIR98520.1Acetolactate synthase; Belongs to the TPP enzyme family. (562 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (485 aa)
AIR98782.1Diaminopimelate decarboxylase. (476 aa)
cbsPutative cystathionine beta-synthase. (462 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
AIR99068.1Threonine synthase. (441 aa)
vdhValine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (364 aa)
cysAPutative cystathionine gamma-lyase. (380 aa)
dapCPutative N-succinyldiaminopimelate aminotransferase DapC. (393 aa)
askAspartokinase; Belongs to the aspartokinase family. (425 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (350 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (617 aa)
folD2Bifunctional protein FolD 2; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
glyA1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (484 aa)
metBCystathionine gamma-synthase. (384 aa)
AIS00224.1Threonine dehydratase. (409 aa)
alaAGlutamate-pyruvate aminotransferase AlaA. (423 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
homHomoserine dehydrogenase. (429 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (315 aa)
glyA2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
sdaAL-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
glyA3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
AIS00667.1Methionine synthase, vitamin-B12 independent. (335 aa)
AIS00681.1Dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
ilvBAcetolactate synthase. (618 aa)
ilvHAcetolactate synthase small subunit. (174 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
ilvEPutative branched-chain-amino-acid aminotransferase. (362 aa)
AIS00701.1Putative AIPM/Hcit synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa)
dapA24-hydroxy-tetrahydrodipicolinate synthase 2; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (293 aa)
AIS01221.1Homocysteine methyltransferase. (323 aa)
AIS01291.1Putative aspartate aminotransferase. (402 aa)
AIS01812.1Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
folD1Bifunctional protein FolD 1; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
Your Current Organism:
Streptomyces glaucescens
NCBI taxonomy Id: 1907
Other names: ATCC 19761, ATCC 23622, Actinomyces glaucescens, BCRC 11478, CBS 499.68, CCRC 11478, CCRC:11478, CECT 3133, DSM 40155, IFO 12774, IMET 43584, INA 8731, ISP 5155, JCM 4377, LMG 19330, LMG:19330, NBRC 12774, NCIMB 9619, NCIMB 9844, NRRL B-2706, NRRL-ISP 5155, S. glaucescens, UNIQEM 147, VKM Ac-617
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