(44 nodes) Glyoxylate and dicarboxylate metabolism network (Streptomyces glaucescens)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	katE	Catalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide. (758 aa)
	gcvP	Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
	AIR97346.1	Glutamine synthetase. (454 aa)
	AIR97444.1	Putative methylaspartate mutase E subunit. (426 aa)
	AIR97445.1	Hypothetical protein. (159 aa)
	AIR98000.1	Dihydrolipoamide dehydrogenase. (462 aa)
	glnA1	Glutamine synthetase. (469 aa)
	glnII	Glutamine synthetase 2. (343 aa)
	glnA2	Putative glutamine synthetase 2. (453 aa)
	AIR98111.1	KHG/KDPG aldolase. (300 aa)
	gltA2	Citrate synthase 1; Belongs to the citrate synthase family. (429 aa)
	accA1	Putative acetyl-/propionyl-coenzyme A carboxylase alpha chain. (643 aa)
	AIR98640.1	Oxidoreductase, FAD-binding. (457 aa)
	AIR98792.1	beta-ketoadipyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
	purU	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa)
	citA	Putative citrate synthase 2; Belongs to the citrate synthase family. (366 aa)
	AIR99007.1	propionyl-CoA carboxylase alpha chain. (615 aa)
	AIR99043.1	Hydrolase. (219 aa)
	acsA	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
	AIS00081.1	isobutyryl-CoA mutase, small subunit. (138 aa)
	mdh	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
	glyA1	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (484 aa)
	bhbA	Methylmalonyl-CoA mutase. (526 aa)
	bccA	Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (591 aa)
	pccB	Propionyl-CoA carboxylase beta chain. (531 aa)
	bca	Bromoperoxidase-catalase; Belongs to the catalase family. (484 aa)
	glyA2	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
	AIS00586.1	methylmalonyl-CoA epimerase. (146 aa)
	AIS00587.1	Putative acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	AIS00603.1	isobutyryl-CoA mutase A. (566 aa)
	glyA3	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
	gcvH	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
	gcvT	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
	AIS01079.1	Aconitate hydratase. (944 aa)
	AIS01264.1	acetyl-CoA synthetase. (557 aa)
	gcl	Glyoxylate carboligase; Belongs to the TPP enzyme family. (594 aa)
	katA	Catalase; Belongs to the catalase family. (485 aa)
	garR	2-hydroxy-3-oxopropionate reductase. (297 aa)
	AIS01278.1	Putative hydroxypyruvate isomerase; Belongs to the hyi family. (279 aa)
	AIS01300.1	Putative malate synthase; Belongs to the malate synthase family. (541 aa)
	lpdC	Dihydrolipoyl dehydrogenase. (470 aa)
	AIS01382.1	Transferase; Belongs to the glycerate kinase type-1 family. (385 aa)
	meaA	Protein MeaA. (675 aa)
	fadA	Putative acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)

Your Current Organism:

Streptomyces glaucescens

NCBI taxonomy Id: 1907
Other names: ATCC 19761, ATCC 23622, Actinomyces glaucescens, BCRC 11478, CBS 499.68, CCRC 11478, CCRC:11478, CECT 3133, DSM 40155, IFO 12774, IMET 43584, INA 8731, ISP 5155, JCM 4377, LMG 19330, LMG:19330, NBRC 12774, NCIMB 9619, NCIMB 9844, NRRL B-2706, NRRL-ISP 5155, S. glaucescens, UNIQEM 147, VKM Ac-617

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIR97346.1	AIR97444.1	SGLAU_06650	SGLAU_07145	Glutamine synthetase.	Putative methylaspartate mutase E subunit.	0.800
AIR97346.1	AIR97445.1	SGLAU_06650	SGLAU_07150	Glutamine synthetase.	Hypothetical protein.	0.800
AIR97346.1	AIR98000.1	SGLAU_06650	SGLAU_09950	Glutamine synthetase.	Dihydrolipoamide dehydrogenase.	0.638
AIR97346.1	gcvH	SGLAU_06650	SGLAU_23480	Glutamine synthetase.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.644
AIR97346.1	gcvP	SGLAU_06650	SGLAU_05485	Glutamine synthetase.	Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.749
AIR97346.1	gcvT	SGLAU_06650	SGLAU_23485	Glutamine synthetase.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.653
AIR97346.1	glnA1	SGLAU_06650	SGLAU_10040	Glutamine synthetase.	Glutamine synthetase.	0.920
AIR97346.1	glnA2	SGLAU_06650	SGLAU_10185	Glutamine synthetase.	Putative glutamine synthetase 2.	0.922
AIR97346.1	glnII	SGLAU_06650	SGLAU_10080	Glutamine synthetase.	Glutamine synthetase 2.	0.900
AIR97346.1	lpdC	SGLAU_06650	SGLAU_27175	Glutamine synthetase.	Dihydrolipoyl dehydrogenase.	0.638
AIR97444.1	AIR97346.1	SGLAU_07145	SGLAU_06650	Putative methylaspartate mutase E subunit.	Glutamine synthetase.	0.800
AIR97444.1	AIR97445.1	SGLAU_07145	SGLAU_07150	Putative methylaspartate mutase E subunit.	Hypothetical protein.	0.999
AIR97444.1	AIS00081.1	SGLAU_07145	SGLAU_20635	Putative methylaspartate mutase E subunit.	isobutyryl-CoA mutase, small subunit.	0.826
AIR97444.1	glnA1	SGLAU_07145	SGLAU_10040	Putative methylaspartate mutase E subunit.	Glutamine synthetase.	0.800
AIR97444.1	glnA2	SGLAU_07145	SGLAU_10185	Putative methylaspartate mutase E subunit.	Putative glutamine synthetase 2.	0.800
AIR97444.1	glnII	SGLAU_07145	SGLAU_10080	Putative methylaspartate mutase E subunit.	Glutamine synthetase 2.	0.800
AIR97444.1	meaA	SGLAU_07145	SGLAU_27250	Putative methylaspartate mutase E subunit.	Protein MeaA.	0.826
AIR97445.1	AIR97346.1	SGLAU_07150	SGLAU_06650	Hypothetical protein.	Glutamine synthetase.	0.800
AIR97445.1	AIR97444.1	SGLAU_07150	SGLAU_07145	Hypothetical protein.	Putative methylaspartate mutase E subunit.	0.999
AIR97445.1	AIS00603.1	SGLAU_07150	SGLAU_23270	Hypothetical protein.	isobutyryl-CoA mutase A.	0.784

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