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| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (143 aa) |
| | CDZ74951.1 | Riboflavin biosynthesis protein RibF; This family represents the C-terminal region of the bifunctional riboflavin biosynthesis protein known as RibC in Bacillus subtilis. The RibC protein from Bacillus subtilis has both flavokinase and flavin adenine dinucleotide synthetase (FAD-synthetase) activities. RibC plays an essential role in the flavin metabolism; High confidence in function and specificity; Belongs to the ribF family. (304 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate (aka glycerone phosphate, outdated) to sn-glycerol 3-phosphate; High confidence in function and specificity. (334 aa) |
| | plsY | Glycerol 3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (199 aa) |
| | CDZ74990.1 | Hypothetical protein; High confidence in function and specificity. (446 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (157 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (349 aa) |
| | CDZ75019.1 | Phosphatidate cytidylyltransferase; The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferaseas well as Sec59 from yeast. Sec59 is a dolichol kinase; High confidence in function and specificity; Belongs to the CDS family. (256 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa) |
| | relA | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (717 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (326 aa) |
| | arcC | Carbamate kinase is involved in the last step of the AD pathway, converting carbamoyl phosphate and ADP into ammonia, carbon dioxide and ATP; High confidence in function and specificity. (312 aa) |
| | CDZ75106.1 | Deoxyguanosinetriphosphate triphosphohydrolase-like protein; Deoxyguanosine triphosphate triphosphohydrolase (dGTPase) releases inorganic triphosphate, an unusual reaction product, from GTP.dGTPase preferentially hydrolyses dGTP over the other canonical NTPs; High confidence in function and specificity; Belongs to the dGTPase family. Type 2 subfamily. (338 aa) |
| | CDZ75114.1 | Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA) utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low allowing DAG to be used for glycerophospholipid biosynthesis but on receptor activation of the phosphoinositide pathway, DGK activity increases driving the conversion of DAG to PA; High confidence in function and specificity. (235 aa) |
| | hinT | Purine nucleoside phosphoramidase; HIT (histidine triad) proteins, named for a short motif related to the sequence (His-x-His-x-His-x-x, where x is a hydrophobic residue) [1,2] are a superfamily of nucleotide hydrolases which acts on the alpha-phosphate of ribonucleotides; High confidence in function and specificity. (112 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (208 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (232 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (202 aa) |
| | citF | In citrate-utilising prokaryotes, citrate lyasecleaves intracellular citrate into acetate and oxaloacetate, and is organised as a functional complex consisting of alpha, beta, and gamma subunits. The gamma subunit serves as an acyl carrier protein (ACP), and has a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group; High confidence in function and specificity. (515 aa) |
| | citE | In citrate-utilising prokaryotes, citrate lyasecleaves intracellular citrate into acetate and oxaloacetate, and is organised as a functional complex consisting of alpha, beta, and gamma subunits. The gamma subunit serves as an acyl carrier protein (ACP), and has a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group; High confidence in function and specificity; Belongs to the HpcH/HpaI aldolase family. (300 aa) |
| | nnrE | Hypothetical protein; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family. (213 aa) |
| | CDZ75208.1 | IMP + diphosphate <=> hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate; High confidence in function and specificity; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | CDZ75215.1 | Putative tetrapyrrole methylase family protein/MazG family protein; Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including cobalamin (vitamin B12), haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin; High confidence in function and specificity. (288 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | glmU | Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (459 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | CDZ75318.1 | tRNA A37 threonylcarbamoyladenosine dehydratase [Translation, ribosomal structure and biogenesis]; High confidence in function and specificity. (226 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | gpmI | Phosphoglycerate mutase (2,3-diphosphoglycerate-independent); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (504 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgk | Phosphoglycerate kinase is an enzyme that catalyses the formation of ATP to ADP and vice versa. In the second step of the second phase in glycolysis, 1,3-diphosphoglycerate is converted to 3-phosphoglycerate, forming one molecule of ATP. If the reverse were to occur, one molecule of ADP would be formed. This reaction is essential in most cells for the generation of ATP in aerobes, for fermentation in anaerobes and for carbon fixation in plants; High confidence in function and specificity. (395 aa) |
| | pgi | Glucose-6-phosphate isomerase (alternatively known as phosphoglucose isomerase or phosphohexose isomerase) is an enzyme that catalyzes the conversion of glucose-6-phosphate into fructose 6-phosphate in the second step of glycolysis; High confidence in function and specificity. (414 aa) |
| | clsA | Major cardiolipin synthase ClsA; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (491 aa) |
| | CDZ75378.1 | Hypothetical protein; High confidence in function and specificity. (467 aa) |
| | CDZ75400.1 | Diacylglycerol kinase family enzyme; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family; High confidence in function and specificity. (296 aa) |
| | CDZ75405.1 | Guanylate kinase, also called GMP kinase, is essential for recycling GMP and indirectly, cGMP. This enzyme transfers a phosphate from ATP to GMP, yielding ADP and GDP. Guanylate kinase is a highly conserved monomer and is important for the activation of various antiviral drugs; High confidence in function and specificity. (179 aa) |
| | CDZ75430.1 | Diacylglycerol kinase catalytic subunit; The Escherichia coli member of this family, YegS, has been purified and shown to have phosphatidylglycerol kinase activity. DagK from Bacillus subtilis catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway. Is more active toward long-chain DAG compared with short-chain DAG. Is not able to phosphorylate substrates other than DAG, such as [...] (300 aa) |
| | CDZ75443.1 | His protein is found in the ComE operon for 'late competence' as characterized in B. subtilis. Proteins in this family contain homology to a cytidine/deoxycytidine deaminase domain family (pfam00383), and may carry out this activity; High confidence in function and specificity. (140 aa) |
| | fda | Fructose-bisphosphate aldolase class 1; D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate; High confidence in function and specificity. (296 aa) |
| | purD | Phosphoribosylformylglycinamidine synthase; Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the ATP-grasp domain of biotin carboxylase/carbamoyl phosphate synthetase; High confidence in function and specificity; Belongs to the GARS family. (1633 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH; 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide; High confidence in function and specificity. (500 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (184 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; The purine biosynthetic pathway in procaryotes enlists eleven enzymes, six of which use ATP. Enzymes 5 and 6 of this pathway, formylglycinamide ribonucleotide (FGAR) amidotransferase (PurL) and aminoimidazole ribonucleotide (AIR) synthetase (PurM or AIRS) utilise ATP to activate the oxygen of an amide within their substrate toward nucleophilic attack by a nitrogen. PurM (also known as phosphoribosyl-aminoimidazole synthetase or phosphoribosylformylglycinamidine cyclo-ligase) uses the product of PurL, formylglycinamidine ribonucleotide (FG [...] (343 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (448 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (506 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl-carrier- protein]dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs; High confidence in function and specificity. (140 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | surE | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (247 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (419 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (276 aa) |
| | purC | Phosphoribosylaminoimidazole- succinocarboxamidesynthase; ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate <=> ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate; High confidence in function and specificity; Belongs to the SAICAR synthetase family. (226 aa) |
| | pyk | ATP + pyruvate = ADP + phosphoenolpyruvate; High confidence in function and specificity; Belongs to the pyruvate kinase family. (579 aa) |
| | coaX1 | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (259 aa) |
| | CDZ74269.1 | Hypothetical protein; Frameshift; Family membership. (1929 aa) |
| | CDZ74325.1 | Putative cytidylate kinase; This family includes enzymes related to cytidylate kinase; High confidence in function and specificity. (213 aa) |
| | CDZ74334.1 | V-type proton ATPase subunit E; This family includes the vacuolar ATP synthase E subunit as well as the archaebacterial ATP synthase E subunit; Hypothetical protein. (185 aa) |
| | atpF | V-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (102 aa) |
| | atpA | V-ATPase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (625 aa) |
| | atpB | V-ATPase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (488 aa) |
| | atpD | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | CDZ74394.1 | Putative ATP:guanido phosphotransferase domain protein; The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain; High confidence in function and specificity. (324 aa) |
| | CDZ74397.1 | acyl-CoA thioester hydrolase family protein; This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters; High confidence in function and specificity. (168 aa) |
| | ushA | 2',3'-cyclic-nucleotide 2'-phosphodiesterase is a bifunctional enzyme localized to the periplasm of Gram-negative bacteria. 2',3'-cyclic-nucleotide 2'-phosphodiesters are intermediates formed during the hydrolysis of RNA by the ribonuclease I, which is also found to the periplasm, and other enzymes of the RNAse T2 family. Bacteria are unable to transport 2',3'-cyclic-nucleotides into the cytoplasm. 2',3'-cyclic-nucleotide 2'-phosphodiesterase contains 2 active sites which catalyze the reactions that convert the 2',3'-cyclic-nucleotide into a 3'-nucleotide, which is then converted into [...] (503 aa) |
| | CDZ74432.1 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (196 aa) |
| | plsC | This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This domain is found in tafazzins, defects in which are the cause of Barth syndrome; a severe inherited disorder which is often fatal in childhood and is characterised by cardiac and skeletal abnormalities. Phospholipid/glycerol acyltransferase is not found in the viruses or the archaea and is under represented in the bacteria. Bacterial glycerol-phosphate acyltransferases are involved in membrane biogenesis since they use fatty acid chains to form the first membrane phos [...] (196 aa) |
| | ispH | Putative 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (693 aa) |
| | coaX3 | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (262 aa) |
| | CDZ74505.1 | Hypothetical protein; High confidence in function and specificity. (391 aa) |
| | nnrD | Carbohydrate kinase family protein; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (399 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (647 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (505 aa) |
| | CDZ74539.1 | Metallo-beta-lactamase superfamily; High confidence in function and specificity. (265 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (223 aa) |
| | CDZ74550.1 | Glutamate synthase (NADPH), homotetrameric; One pathway for the assimilation of ammonia and glutamate biosynthesis involves homotetrameric glutamate synthase which transfers the amide group of glutamine to 2-oxoglutarate to yield two molecules of glutamate. 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+; High confidence in function and specificity. (774 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (205 aa) |
| | CDZ74580.1 | HD superfamily hydrolase; Metal dependent phosphohydrolases with conserved 'HD' motif; High confidence in function and specificity. (194 aa) |
| | CDZ74591.1 | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (331 aa) |
| | acoC | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Biotin and lipoic acid moieties are the covalently bound cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. They are attached to a lysine residue, via an amide bond, by specific biotinyl and lipoyl protein ligases. The lipoyl-lysine and biotinyl-lysine residues serve as swinging arms, ferrying substrate between the three active sites in their relevant enzyme complexes; High confidence in function and specificity. (433 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (169 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (236 aa) |
| | ispE | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (282 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (530 aa) |
| | CDZ74691.1 | The Nudix family is a protein family of phosphohydrolases.Using water-mediated catalysis they break a phosphate bond in their substrate to create two products. Nudix stands for Nucleoside Diphosphate linked to X; High confidence in function and specificity. (170 aa) |
| | thyX | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (252 aa) |
| | ppnK | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (267 aa) |
| | CDZ74700.1 | The DAG-kinase catalytic domain or DAGKc domain is present in mammalian lipid kinases, such as diacylglycerol (DAG), ceramide and sphingosine kinases, as well as in related bacterial proteins; High confidence in function and specificity. (296 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (497 aa) |
| | pyrB | Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate; High confidence in function and specificity; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (304 aa) |
| | CDZ74715.1 | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase; High confidence in function and specificity. (143 aa) |
| | CDZ74716.1 | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD+; High confidence in function and specificity. (233 aa) |
| | pyrD | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (300 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (199 aa) |
| | CDZ74752.1 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa) |
| | CDZ74762.1 | Ribulose-phosphate 3-epimerase; D-ribulose 5-phosphate = D-xylulose 5-phosphate; High confidence in function and specificity; Belongs to the ribulose-phosphate 3-epimerase family. (215 aa) |
| | CDZ74763.1 | Thiamine diphosphokinase; Thiamin pyrophosphokinase (TPK, catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions; High confidence in function and specificity. (209 aa) |
| | dacA | Protein of hypothetical; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (280 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (239 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa) |
| | tal | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa) |
| | CDZ74796.1 | Putative Fructose-1-phosphate kinase; High confidence in function and specificity. (302 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (218 aa) |
| | CDZ74831.1 | Putative Ser/Thr protein phosphatase family protein; Predicted phosphohydrolases [General function prediction only]; High confidence in function and specificity. (254 aa) |
| | thiI | Putative tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (386 aa) |
| | cinA | Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use components of extracellular filaments called type 4 pili to create pores in their membranes and pull DNA through the pores into the cytoplasm. This process, including the development of competence and the expression of the uptake machinery, is regulated in response to cell-cell [...] (405 aa) |
| | CDZ74945.1 | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase; All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond; High confidence in function and specificity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (177 aa) |
