STRINGSTRING
ANS62246.1 ANS62246.1 ANS62309.1 ANS62309.1 ANS62615.1 ANS62615.1 ANS62902.1 ANS62902.1 ANS62912.1 ANS62912.1 ANS62970.1 ANS62970.1 ANS62971.1 ANS62971.1 ANS63455.1 ANS63455.1 ANS63589.1 ANS63589.1 ANS64738.1 ANS64738.1 ANS64739.1 ANS64739.1 ANS64742.1 ANS64742.1 ANS64942.1 ANS64942.1 ANS65021.1 ANS65021.1 ANS65105.1 ANS65105.1 ANS65379.1 ANS65379.1 ANS65420.1 ANS65420.1 ANS65581.1 ANS65581.1 ppc ppc ANS65967.1 ANS65967.1 ANS65999.1 ANS65999.1 ANS66006.1 ANS66006.1 ANS66539.1 ANS66539.1 ANS66540.1 ANS66540.1 ANS66541.1 ANS66541.1 ANS66554.1 ANS66554.1 ANS66555.1 ANS66555.1 ANS66556.1 ANS66556.1 acsA acsA ANS67148.1 ANS67148.1 ANS67207.1 ANS67207.1 ANS67208.1 ANS67208.1 ANS67370.1 ANS67370.1 sucC sucC sucD sucD mdh mdh ANS67462.1 ANS67462.1 ANS67463.1 ANS67463.1 ANS67464.1 ANS67464.1 ANS67465.1 ANS67465.1 ANS67529.1 ANS67529.1 ANS67533.1 ANS67533.1 ANS67534.1 ANS67534.1 pckG pckG fumC fumC ANS67655.1 ANS67655.1 ANS67891.1 ANS67891.1 ANS67908.1 ANS67908.1 ackA ackA ANS68040.1 ANS68040.1 ANS68468.1 ANS68468.1 ANS68469.1 ANS68469.1 ANS68599.1 ANS68599.1 ANS68625.1 ANS68625.1 ANS68954.1 ANS68954.1 ANS69002.1 ANS69002.1 ANS69163.1 ANS69163.1 sucC-2 sucC-2 sucD-2 sucD-2 ANS69543.1 ANS69543.1 ANS69612.1 ANS69612.1 ANS69614.1 ANS69614.1 ANS69615.1 ANS69615.1 ANS69811.1 ANS69811.1 ANS69949.1 ANS69949.1 ANS70126.1 ANS70126.1 ANS70127.1 ANS70127.1 ANS70129.1 ANS70129.1 ANS70142.1 ANS70142.1 ANS70239.1 ANS70239.1 ANS70402.1 ANS70402.1 ANS70403.1 ANS70403.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANS62246.1Dihydrolipoyl dehydrogenase. (519 aa)
ANS62309.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (448 aa)
ANS62615.1Carboxyl transferase. (527 aa)
ANS62902.1Dihydrolipoamide dehydrogenase. (470 aa)
ANS62912.1acyl-CoA synthetase/AMP-acid ligase. (629 aa)
ANS62970.1Pyruvate dehydrogenase. (316 aa)
ANS62971.1Hypothetical protein; Belongs to the 2-oxoacid dehydrogenase family. (670 aa)
ANS63455.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1125 aa)
ANS63589.1Putative aldehyde dehydrogenase. (461 aa)
ANS64738.1Dihydrolipoamide dehydrogenase. (462 aa)
ANS64739.1Dihydrolipoamide S-succinyltransferase. (599 aa)
ANS64742.12-oxoacid dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (901 aa)
ANS64942.1Pyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
ANS65021.1Acetyl CoA carboxylase (alpha and beta subunits). (524 aa)
ANS65105.1Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (915 aa)
ANS65379.1Citrate synthase; Belongs to the citrate synthase family. (422 aa)
ANS65420.1Acetyl/propionyl CoA carboxylase alpha subunit. (638 aa)
ANS65581.1Malate oxidoreductase. (471 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (913 aa)
ANS65967.1pimeloyl-CoA synthetase. (741 aa)
ANS65999.1Citrate synthase 2; Belongs to the citrate synthase family. (366 aa)
ANS66006.1Acetyl/propionyl CoA carboxylase alpha subunit. (622 aa)
ANS66539.13-methyl-2-oxobutanoate dehydrogenase E1-alpha chain. (376 aa)
ANS66540.13-methyl-2-oxobutanoate dehydrogenase E1-beta chain. (334 aa)
ANS66541.1Branched-chain alpha-keto acid dehydrogenase subunit E2. (439 aa)
ANS66554.1Branched-chain alpha keto acid dehydrogenase E1 alpha subunit. (404 aa)
ANS66555.1Branched-chain alpha keto acid dehydrogenase E1 beta subunit. (331 aa)
ANS66556.1Branched-chain alpha-keto acid dehydrogenase subunit E2. (477 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
ANS67148.13-ketosteroid-delta-1-dehydrogenase. (576 aa)
ANS67207.12-oxoglutarate ferredoxin oxidoreductase subunit beta. (359 aa)
ANS67208.1Oxidoreductase. (642 aa)
ANS67370.1Succinic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (537 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
ANS67462.1Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
ANS67463.1Succinate dehydrogenase flavoprotein subunit. (584 aa)
ANS67464.1Succinate dehydrogenase membrane subunit. (160 aa)
ANS67465.1Succinate dehydrogenase cytochrome b-556 subunit. (110 aa)
ANS67529.1acyl-CoA carboxylase, alpha subunit. (590 aa)
ANS67533.1propionyl-CoA carboxylase complex B subunit. (540 aa)
ANS67534.1Biotin apo-protein ligase. (287 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (610 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (451 aa)
ANS67655.1Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
ANS67891.1Malate oxidoreductase. (407 aa)
ANS67908.1Alpha-ketoglutarate decarboxylase. (1265 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (407 aa)
ANS68040.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
ANS68468.1Hypothetical protein. (418 aa)
ANS68469.1Citrate synthase; Belongs to the citrate synthase family. (396 aa)
ANS68599.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
ANS68625.1Dehydrogenase. (330 aa)
ANS68954.1acetyl-CoA synthetase. (556 aa)
ANS69002.1Malate synthase; Belongs to the malate synthase family. (544 aa)
ANS69163.1Thiamine pyrophosphate protein; Belongs to the TPP enzyme family. (598 aa)
sucC-2succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (376 aa)
sucD-2succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (309 aa)
ANS69543.1Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (738 aa)
ANS69612.1Cytochrome b subunit. (222 aa)
ANS69614.1Succinate dehydrogenase flavoprotein subunit. (649 aa)
ANS69615.1Succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (249 aa)
ANS69811.1NADP oxidoreductase, coenzyme F420-dependent:6-phosphogluconate dehydrogenase, NAD-binding protein. (304 aa)
ANS69949.1L-lactate 2-monooxygenase. (402 aa)
ANS70126.1Formate acetyltransferase. (752 aa)
ANS70127.1Pyruvate-formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (248 aa)
ANS70129.1Alcohol dehydrogenase, class IV; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (888 aa)
ANS70142.1Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (890 aa)
ANS70239.1Carboxyl transferase. (524 aa)
ANS70402.1Pyruvate dehydrogenase (cytochrome); Belongs to the TPP enzyme family. (579 aa)
ANS70403.1Malate oxidoreductase. (557 aa)
Your Current Organism:
Streptomyces lincolnensis
NCBI taxonomy Id: 1915
Other names: ATCC 25466, BCRC 11173, CBS 630.70, CBS 699.69, CCRC 11173, CCRC:11173, DSM 2013, DSM 40355, IFO 13054, ISP 5355, JCM 4287, JCM 4488, KCTC 9088, KCTC 9089, NBRC 13054, NCIMB 9413, NRRL 2936, NRRL-ISP 5355, S. lincolnensis, VKM Ac-727
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