STRINGSTRING
ANS62704.1 ANS62704.1 ANS63070.1 ANS63070.1 ANS63179.1 ANS63179.1 ANS63239.1 ANS63239.1 ANS63240.1 ANS63240.1 ANS63534.1 ANS63534.1 metK metK ANS63958.1 ANS63958.1 ANS64097.1 ANS64097.1 ANS64659.1 ANS64659.1 leuA leuA ANS65412.1 ANS65412.1 ahcY ahcY ANS65727.1 ANS65727.1 ANS66085.1 ANS66085.1 ANS66289.1 ANS66289.1 ANS66453.1 ANS66453.1 ilvD ilvD ANS67563.1 ANS67563.1 ANS67567.1 ANS67567.1 ANS67590.1 ANS67590.1 metK2 metK2 ANS67672.1 ANS67672.1 ANS67673.1 ANS67673.1 ahcY-2 ahcY-2 ANS67968.1 ANS67968.1 ANS67969.1 ANS67969.1 thrB thrB ANS68166.1 ANS68166.1 ANS68167.1 ANS68167.1 ilvC ilvC leuB leuB ANS68186.1 ANS68186.1 ANS68190.1 ANS68190.1 leuC leuC leuD leuD ANS68860.1 ANS68860.1 ANS68978.1 ANS68978.1 metE metE ANS70029.1 ANS70029.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANS62704.1Threonine dehydratase. (322 aa)
ANS63070.1Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (544 aa)
ANS63179.1Cysteine synthase/cystathionine beta-synthase. (374 aa)
ANS63239.1Hypothetical protein. (262 aa)
ANS63240.1Thiamine pyrophosphate protein central region; Belongs to the TPP enzyme family. (546 aa)
ANS63534.1Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (578 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
ANS63958.1Aminotransferase. (273 aa)
ANS64097.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1173 aa)
ANS64659.15,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (582 aa)
ANS65412.1Acetolactate synthase; Belongs to the TPP enzyme family. (547 aa)
ahcYS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (485 aa)
ANS65727.1Cystathionine beta-synthase. (465 aa)
ANS66085.1Threonine synthase. (428 aa)
ANS66289.1Valine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (364 aa)
ANS66453.1Cystathionine gamma-lyase. (384 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (617 aa)
ANS67563.1Cystathionine gamma-synthase. (384 aa)
ANS67567.1Amino acid deaminase. (409 aa)
ANS67590.1Aminotransferase AlaT. (403 aa)
metK2SAM synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (406 aa)
ANS67672.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1167 aa)
ANS67673.1MetF; Belongs to the methylenetetrahydrofolate reductase family. (301 aa)
ahcY-2S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (469 aa)
ANS67968.1Homoserine dehydrogenase. (433 aa)
ANS67969.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
ANS68166.1Acetolactate synthase 1 catalytic subunit. (618 aa)
ANS68167.1Acetolactate synthase 3 regulatory subunit. (174 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
ANS68186.1Branched-chain amino acid aminotransferase. (362 aa)
ANS68190.1Hypothetical protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
ANS68860.1Homocysteine methyltransferase. (340 aa)
ANS68978.1Aminotransferase AlaT. (402 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (774 aa)
ANS70029.1Transferase. (392 aa)
Your Current Organism:
Streptomyces lincolnensis
NCBI taxonomy Id: 1915
Other names: ATCC 25466, BCRC 11173, CBS 630.70, CBS 699.69, CCRC 11173, CCRC:11173, DSM 2013, DSM 40355, IFO 13054, ISP 5355, JCM 4287, JCM 4488, KCTC 9088, KCTC 9089, NBRC 13054, NCIMB 9413, NRRL 2936, NRRL-ISP 5355, S. lincolnensis, VKM Ac-727
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.