STRINGSTRING
ldh ldh AGT31277.1 AGT31277.1 odhA odhA AGT31337.1 AGT31337.1 pdhA pdhA AGT31374.1 AGT31374.1 AGT31375.1 AGT31375.1 AGT31376.1 AGT31376.1 AGT31395.1 AGT31395.1 sucC sucC sucD sucD AGT31613.1 AGT31613.1 AGT31614.1 AGT31614.1 AGT31753.1 AGT31753.1 AGT32152.1 AGT32152.1 AGT32153.1 AGT32153.1 AGT32336.1 AGT32336.1 pdhA-2 pdhA-2 AGT32679.1 AGT32679.1 AGT32680.1 AGT32680.1 AGT32711.1 AGT32711.1 AGT32712.1 AGT32712.1 AGT32713.1 AGT32713.1 AGT32714.1 AGT32714.1 AGT33009.1 AGT33009.1 sdhA sdhA AGT33011.1 AGT33011.1 pckA pckA AGT33360.1 AGT33360.1 AGT33545.1 AGT33545.1 AGT33546.1 AGT33546.1 pdhA-3 pdhA-3 AGT33548.1 AGT33548.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (318 aa)
AGT31277.1Hydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (271 aa)
odhA2-oxoglutarate dehydrogenase E1; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (951 aa)
AGT31337.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (434 aa)
pdhAPyruvate dehydrogenase E1 subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (369 aa)
AGT31374.12-oxoisovalerate dehydrogenase subunit beta; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (325 aa)
AGT31375.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (432 aa)
AGT31376.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (470 aa)
AGT31395.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
sucCmalate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase subsunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
AGT31613.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (590 aa)
AGT31614.12-oxoacid ferredoxin oxidoreductase subunit beta; Catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (288 aa)
AGT31753.1NAD-dependent malic enzyme; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (480 aa)
AGT32152.1Pyruvate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (764 aa)
AGT32153.1Ferredoxin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (336 aa)
AGT32336.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (332 aa)
pdhA-2Pyruvate dehydrogenase E1 subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (355 aa)
AGT32679.12-oxoacid ferredoxin oxidoreductase subunit beta; Catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (288 aa)
AGT32680.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (578 aa)
AGT32711.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (447 aa)
AGT32712.12-oxoisovalerate dehydrogenase subunit beta; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (327 aa)
AGT32713.12-oxoisovalerate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (331 aa)
AGT32714.1Dihydrolipoamide dehydrogenase; E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (473 aa)
AGT33009.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (253 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (585 aa)
AGT33011.1Succinate dehydrogenase cytochrome B558; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (202 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (523 aa)
AGT33360.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (604 aa)
AGT33545.12-hydroxy-acid oxidase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (455 aa)
AGT33546.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (325 aa)
pdhA-3Pyruvate dehydrogenase E1 subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (376 aa)
AGT33548.1Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (433 aa)
Your Current Organism:
Geobacillus genomosp.
NCBI taxonomy Id: 1921421
Other names: Bacillus sp. JF8, G. genomosp. 3, Geobacillus genomosp. 3, Geobacillus genomospecies 3, Geobacillus sp. JF8
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