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kpsS kpsS kpsC kpsC Cj1421c Cj1421c Cj1422c Cj1422c hddC hddC gmhA2 gmhA2 hddA hddA Cj1426c Cj1426c Cj1427c Cj1427c fcl fcl Cj1429c Cj1429c rfbC rfbC hddC-2 hddC-2 Cj1432c Cj1432c Cj1433c Cj1433c Cj1434c Cj1434c Cj1435c Cj1435c Cj1438c Cj1438c glf glf Cj1440c Cj1440c kfiD kfiD Cj1442c Cj1442c kpsD kpsD kpsE kpsE kpsT kpsT kpsM kpsM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kpsSOriginal (2000) note: Cj1413c, possible polysaccharide modification protein, len: 394 aa; similar to e.g. LIPB_NEIME capsule polysaccharide modification protein (419 aa), fasta scores; opt: 744 z-score: 897.9 E(): 0, 38.5% identity in 395 aa overlap, and KSS5_ECOLI capsule polysaccharide export protein KPSS (389 aa), fasta scores; opt: 919 z-score: 1108.7 E(): 0, 40.2% identity in 383 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05159 Capsule polysaccharide biosynthesis protein identified within CDS. Further support given to product function. Possible removed from produc [...] (394 aa)
kpsCOriginal (2000) note: Cj1414c, possible polysaccharide modification protein, len: 689 aa; similar to e.g. LIPA_NEIME capsule polysaccharide modification protein (400 aa), fasta scores; opt: 927 z-score: 1062.5 E(): 0, 39.6% identity in 394 aa overlap, and KSC5_ECOLI capsule polysaccharide export protein KPSC (675 aa), fasta scores; opt: 724 z-score: 827.0 E(): 0, 38.5% identity in 655 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF05159 Capsule polysaccharide biosynthesis protein identified within CDS. Further support given to product function. Possible removed from produc [...] (689 aa)
Cj1421cPutative sugar transferase; Original (2000) note: Cj1421c, possible sugar transferase, len: 612 aa; no Hp match. Similar to polymorphic tract-containing genes Cj1422c (overall 58.2% identity in 636 aa overlap, but N- and C-terminal 250 and 40 aa are identical), Cj0685c (28.0% identity in 404 aa overlap). N-terminus is simlar to parts of Cj1431c (38.6% identity in 114 aa overlap), and putative sugar transferases Cj1434c (39.6% identity in 111 aa overlap),and Cj1438c (34.6% identity in 127 aa overlap). Contains C(8-10) polymorphic tract at aa 30. C9 (consensus) gives this ORF, C8 gives t [...] (612 aa)
Cj1422cPutative sugar transferase; Original (2000) note: Cj1422c, possible sugar transferase, len: 625 aa; no Hp match. Similar to polymorphic tract-containing genes Cj1421c (overall 58.2% identity in 636 aa overlap, but N- and C-terminal 250 and 40 aa are identical), Cj0685c (25.6% identity in 442 aa overlap). N-terminus is simlar to parts of Cj1431c (38.6% identity in 114 aa overlap), and putative sugar transferases Cj1434c (39.6% identity in 111 aa overlap),and Cj1438c (23.5% identity in 452 aa overlap). Contains C(9-10) polymorphic tract at aa 30. C9 (consensus) gives this ORF, C10 gives [...] (625 aa)
hddCPutative D-glycero-D-manno-heptose 1-phosphate guanosyltransferase; Original (2000) note: Cj1423c, possible sugar-phosphate nucleotidyltransferase, len: 221 aa; similar to many predicted nucleotidyltransferases, e.g. TR:O58775 (EMBL:AP000004) Pyrococcus horikoshii hypothetical sugar-phosphate nucleotydyl transferase PH1022 (416 aa), fasta scores; opt: 413 z-score: 496.0 E(): 2.6e-20, 34.3% identity in 230 aa overlap, and MPG1_YEAST mannose-1-phosphate guanyltransferase (361 aa),fasta scores; opt: 258 z-score: 313.4 E(): 3.9e-10, 28.9% identity in 232 aa overlap. Contains Pfam match to [...] (221 aa)
gmhA2Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (201 aa)
hddAPutative D-glycero-D-manno-heptose 7-phosphate kinase; Original (2000) note: Cj1425c, possible sugar kinase, len: 339 aa; similar to e.g. GAL1_LACHE galactokinase (388 aa), fasta scores; opt: 186 z-score: 227.6 E(): 2.4e-05, 24.3% identity in 371 aa overlap. Contains PS00012 Phosphopantetheine attachment site. No Hp match; Updated (2006) note: Pfam domain PF00288 GHMP kinases putative ATP-binding protein identified within CDS. Further support given to product function. Literature search identified work carried out within Campylobacter jejuni. Not yet fully characterised, so putative ke [...] (339 aa)
Cj1426cPutative methyltransferase family protein; Original (2000) note: Cj1426c, unknown, len: 283 aa; no Hp match. Contains C(10-11) polymorphic region at aa 99. C10 (consensus) gives this ORF, C11 gives truncation after +8 aa; Updated (2006) note: TIGRFAM motif TIGR01444 Methyltransferase FkbM, identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so putative kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c -Cj1448c). Functional classification - Misc; P [...] (283 aa)
Cj1427cOriginal (2000) note: Cj1427c, probable sugar-nucleotide epimerase/dehydratease, len: 313 aa; similar to many predicted epimerases/dehydrateases e.g. TR:Q25130 (EMBL:D25537) HALOCYNTHIA RORETZI (SEA SQUIRT) gene with similarity to UDPglucose4-epimerases and 3beta-hydroxysteroid dehydrogenase/isomerases HREPIB (241 aa), fasta scores; opt: 585 z-score: 691.2 E(): 3.5e-31,44.2% identity in 208 aa overlap, and TR:O73960 (EMBL:AP000002) Pyrococcus horikoshii hypothetical UDP-glucose 4-epimerase (318 aa), fasta scores; opt: 304 z-score: 361.7 E(): 7.9e-13, 26.4% identity in 326 aa overlap. N [...] (313 aa)
fclGDP-L-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (346 aa)
Cj1429cHypothetical protein Cj1429c; Original (2000) note: Cj1429c, unknown, len: 308 aa; no Hp match. Contains C(9-10) polymorphic region at aa 98. C10 (consensus) gives this ORF, C9 would give truncation after +1 aa; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Unknown; PMID:15612919, PMID:10672176. (308 aa)
rfbCPutative dTDP-4-dehydrorhamnose 3,5-epimerase; Original (2000) note: Cj1430c, probable nucleotide-sugar epimerase/dehydratase, len: 181 aa; similar to e.g. RFBC_ECOLI DTDP-4-dehydrorhamnose 3,5-epimerase (185 aa), fasta scores; opt: 303 z-score: 386.2 E(): 3.4e-14, 33.9% identity in 165 aa overlap, and TR:Q46770 (EMBL:U23775) E. coli rmlC DTDP-6-deoxy-l-lyxo-4-hexulose reductase (183 aa), fasta scores; opt: 306 z-score: 390.0 E(): 2.1e-14, 33.5% identity in 164 aa overlap. No Hp match. Contains Pfam match to entry PF00908 dTDP_sugar_isom,dTDP-4-dehydrorhamnose 3,5-epimerase; Updated (2 [...] (181 aa)
hddC-2Capsular polysaccharide heptosyltransferase; Original (2000) note: Cj1431c, unknown, len: 582 aa; no Hp match. Similar in part to N-termini of Cj1421c (38.6% identity in 114 aa overlap), and Cj1422c (38.6% identity in 114 aa overlap). Contains PS00455 Putative AMP-binding domain signature; Updated (2006) note: Characterised within Campylobacter jejuni. Product modified to more specific family member based on literature search results. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides, lipopolysaccharides and [...] (582 aa)
Cj1432cPutative sugar transferase; Original (2000) note: Cj1432c, possible sugar transferase, len: 1031 aa; weakly similar to e.g. TR:Q48232 (EMBL:X78559) Haemophilus influenzae orf3 in DNA for serotypE B capsulation locus (1215 aa), fasta scores; opt: 361 z-score: 398.4 E(): 7.2e-15, 22.8% identity in 1029 aa overlap, and TR:O84910 (EMBL:AF010183) glycosyltransferase WBPZ (381 aa), fasta scores; opt: 161 z-score: 182.7 E(): 0.0074, 23.1% identity in 251 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1. Also similar to Cj1434c (23.1% identity in [...] (1031 aa)
Cj1433cHypothetical protein Cj1433c; Original (2000) note: Cj1433c, unknown, len: 368 aa; no Hp match. Contains 9 repeats of the aa sequence KIDLNNT near the N-terminus; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Unknown; PMID:15612919, PMID:10672176. (368 aa)
Cj1434cPutative sugar transferase; Original (2000) note: Cj1434c, probable sugar transferase, len: 445 aa; similar in N-terminus to e.g. TR:O07340 (EMBL:O07340) Streptococcus pneumoniae SS-1,4-galactosyltransferase (318 aa), fasta scores; opt: 344 z-score: 405.7 E(): 2.8e-15, 27.3% identity in 326 aa overlap. No Hp ortholog. Highly similar to Cj1438c (72.4% identity in 456 aa overlap). Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: No specific characterisation has been carried out yet, so putative kept within product function. Literature sear [...] (445 aa)
Cj1435cPutative phosphatase; Original (2000) note: Cj1435c, unknown, len: 211 aa; similar to TR:Q58989 (EMBL:U67599) Methanococcus jannaschii hypothetical protein MJ1594 (211 aa), fasta scores; opt: 177 z-score: 228.6 E(): 2.1e-05, 23.5% identity in 196 aa overlap. No Hp match; Updated (2006) note: TIGRFAM motifs identified HAD-superfamily proteins within CDS. Literature search identified paper giving further information to product function. Product function modified to more specific family member due to motif identification and literature search. Specific characterisation still required, so [...] (211 aa)
Cj1438cPutative sugar transferase; Original (2000) note: Cj1438c, probable sugar transferase, len: 776 aa; similar in N-terminus to e.g. TR:O07340 (EMBL:O07340) Streptococcus pneumoniae SS-1,4-galactosyltransferase (318 aa), fasta scores; opt: 325 z-score: 375.2 E(): 1.4e-13, 26.9% identity in 316 aa overlap. Similar in C-terminus to TR:O31348 (EMBL:Y11138) Bacillus cereus hypothetical protein (ORF2) (300 aa),fasta scores; opt: 355 z-score: 409.9 E(): 1.7e-15, 31.2% identity in 340 aa overlap. 27.7% identity in 260 aa overlap to HP0102. Also highly similar to Cj1434c (72.9% identity in 457 aa [...] (776 aa)
glfUDP-galactopyranose mutase; Original (2000) note: Cj1439c, glf, probable UDP-galactopyranose mutase, len: aa; highly simiar to e.g. TR:O86897 (EMBL:AJ006986) Streptococcus pneumoniae polysaccharide capsule bisynthesis cluster UDP-galactopyranose mutase (EC 5.4.99.9) (369 aa), fasta scores; opt: 1546 z-score: 1775.3 E(): 0, 59.9% identity in 364 aa overlap, and GLF_ECOLI UDP-galactopyranose mutase (EC 5.4.99.9) (367 aa), fasta scores; opt: 1545 z-score: 1774.2 E(): 0, 60.8% identity in 362 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03275 UDP-galactopyranose mutase ident [...] (368 aa)
Cj1440cPutative sugar transferase; Original (2000) note: Cj1440c, probable sugar transferase, len: 407 aa; similar in N-terminus to e.g. TR:O07340 (EMBL:O07340) Streptococcus pneumoniae SS-1,4-galactosyltransferase (318 aa), fasta scores; opt: 280 z-score: 326.2 E(): 7.5e-11, 26.7% identity in 374 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases; Updated (2006) note: Literature search identified papers giving further information towards product function. Specific characterisation still required, so putative kept within product function. I [...] (407 aa)
kfiDUDP-glucose 6-dehydrogenase; Original (2000) note: Cj1441c, kfiD, probable UDP-glucose 6-dehydrogenase, len: 393 aa; similar to many e.g. UDG5_ECOLI UDP-glucose 6-dehydrogenase (EC 1.1.1.22) (392 aa), fasta scores; opt: 1386 z-score: 1511.4 E(): 0,52.3% identity in 392 aa overlap. No Hp match. Contains Pfam match to entry PF00984 UDPG_MGDP_dh,UDP-glucose/GDP-mannose dehydrogenase family; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1 [...] (393 aa)
Cj1442cPutative sugar transferase; Original (2000) note: Cj1442c, unknown, len: 544 aa; no Hp match; Updated (2006) note: Literature search identified papers giving further information about product function. Specific characterisation still required, so putative kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Surface polysaccharides,lipopolysaccharides and antigens; PMID:15612919, PMID:10672176, PMID:11422559. (544 aa)
kpsDOriginal (2000) note: Cj1444c, kpsD, probable capsule polysaccharide export system periplasmic protein,len: aa; similar to e.g. KSD1_ECOLI polysialic acid transport protein KPSD PREC (558 aa), fasta scores; opt: 1187 z-score: 1306.9 E(): 0, 36.1% identity in 560 aa overlap. Contains probable N-terminal signal sequence. No Hp match; Updated (2006) note: Pfam domain PF02563 Polysaccharide biosynthesis/export protein identified within CDS. Paper identified linking protein to glycoprotein (PMID:Cj12186869). Characterised within Escherichia coli with acceptable identity score. Putative remo [...] (552 aa)
kpsEOriginal (2000) note: Cj1445c, kpsE, probable capsule polysaccharide export system inner membrane protein, len: 372 aa; similar to e.g. KSE1_ECOLI capsule polysaccharide export inner-membrane protein (382 aa),fasta scores; opt: 752 z-score: 755.4 E(): 0, 34.2% identity in 351 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02706 Chain length determinant protein identified within CDS. Further support given to product function. Two probable transmembrane helices predicted by TMHMM2.0. Characterised within Escherichia coli with acceptable identity score. Putative removed from [...] (372 aa)
kpsTOriginal (2000) note: Cj1447c, kpsT, probable capsule polysaccharide export ATP-binding protein, len: 220 aa; identical to TR:O69286 (EMBL:AJ000856) C. jejuni ABC transporter protein (220 aa), and highly similar to e.g. KST1_ECOLI polysialic acid transport ATP-binding protein (219 aa), fasta scores; opt: 810 z-score: 945.3 E(): 0, 58.7% identity in 218 aa overlap. No Hp ortholog. Contains PS00017 ATP/GTP-binding site motif A (P-loop),PS00211 ABC transporters family signature, and Pfam match to entry PF00005 ABC_tran, ABC transporters; Updated (2006) note: Characterised within Campyloba [...] (220 aa)
kpsMOriginal (2000) note: Cj1448c, kpsM, probable capsule polysaccharide export system inner membrane protein, len: 260 aa; identical to TR:O69285 (EMBL:AJ000856) C. jejuni ABC transporter protein (260 aa), and highly similar to e.g. KPM1_ECOLI polysialic acid transport protein KPSM (258 aa), fasta scores; opt: 488 z-score: 558.3 E(): 8.9e-24, 34.3% identity in 254 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01061 ABC-2 type transporter identified within CDS. Further support given to product function. Also, six probable transmembrane helices predicted by TMHMM2.0. Character [...] (260 aa)
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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