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cdtC cdtC cdtB cdtB cdtA cdtA clpP clpP cmeC cmeC cmeB cmeB cmeA cmeA ciaB ciaB hipO hipO gyrA gyrA csrA csrA htrB htrB racR racR flaA flaA cadF cadF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdtCOriginal (2000) note: Cj0077c, cdtC, cytolethal distending toxin, len: 189 aa, identical to TR:Q46102 (EMBL:U51121) cdtC (189 aa). No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF03499 Cytolethal distending toxin C identified within CDS. Product modified to more specific family member due to motif match. Characterised within Campylobacter jejuni, so putative not added to product function. Functional classification -Pathogenicity; PMID:10688204, PMID:8675309, PMID:11083762. (189 aa)
cdtBOriginal (2000) note: Cj0078c, cdtB, cytolethal distending toxin, len: 265 aa; identical toTR:Q46101 (EMBL:U51121) cdtB (265 aa) and similar to e.g. TR:Q47089 (EMBL:U03293) Escherichia coli cdtB (273 aa), fasta scores; opt: 946 z-score: 1533.6 E(): 0, 55.2% identity in 268 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Prosite domain PRO1388 CDTOXINB, Cytolethal distending toxin B signature identified within CDS. Product modified to more specific family member due to motif match. Characterised within Campylobacter jejuni, so putative not added to pro [...] (265 aa)
cdtACytolethal distending toxin A; CDTs are cytotoxins which induce cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. (268 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (194 aa)
cmeCOuter membrane channel protein CmeC (multidrug efflux system CmeABC); Original (2000) note: Cj0365c, possible outer membrane channel protein, len: 492 aa; similar to members of the nodT/fusA family e.g. TR:O31101 (EMBL:AF029405) Pseudomonas putida outer membrane channel protein SRPC (470 aa), fasta scores; opt: 645 z-score: 834.4 E(): 0,29.2% identity in 465 aa overlap. and TR:Q51006 (EMBL:X95635) Neisseria gonorrhoeae mtrE gene (467 aa,fasta scores; opt: 663 z-score: 829.8 E(): 0, 31.1% identity in 476 aa overlap. No Hp match. Also some similarity to Cj0608 (28.6% identity in 455 aa o [...] (492 aa)
cmeBInner membrane efflux transporter CmeB (multidrug efflux system CmeABC); Original (2000) note: Cj0366c, probable transmembrane efflux protein, len: 1040 aa; similar to e.g. TR:P95422 (EMBL:X99514) Pseudomonas aeruginosa mexF (antibiotic efflux system protein) (1062 aa), fasta scores; opt: 1584 z-score: 3208.4 E(): 0, 41.2% identity in 1056 aa overlap, and ACRB_ECOLI acriflavin resistance protein B (1049 aa), fasta scores; opt: 2739 z-score: 3055.6 E(): 0, 41.7% identity in 1031 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00873 ACR_tran,AcrB/AcrD/AcrF family, score 1415.1 [...] (1040 aa)
cmeAPeriplasmic fusion protein CmeA (multidrug efflux system CmeABC); Original (2000) note: Cj0367c, possible membrane fusion component of efflux system, len: 367 aa; similar to e.g. MTRC_NEIGO membrane fusion protein MTRC precursor (412 aa), fasta scores; opt: 592 z-score: 692.4 E(): 2.6e-31, 29.9% identity in 358 aa overlap, and TR:P95421 (EMBL:X99514) Pseudomonas aeruginosa mexE (antibiotic efflux system protein) (414 aa), fasta scores; opt: 460 z-score: 570.0 E(): 1.7e-24, 26.9% identity in 357 aa overlap. No Hp ortholog. Contains N-terminal signal sequence and PS00013 Prokaryotic memb [...] (367 aa)
ciaBCiaB protein; Original (2000) note: Cj0914c, ciaB, unknown function, len: 610 aa; no Hp match. Product is translocated into host cells. Mutants fail to translocate,and fail to translocate other proteins. Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature; Updated (2006) note: Papers attached giving further information regarding this CDS. Functional classification - Pathogenicity; PMID:10361274, PMID:10540297, PMID:10659361,PMID:15722140. (610 aa)
hipOHippurate hydrolase; Cleaves hippuric acid into benzoic acid and glycine. Belongs to the peptidase M20 family. (383 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (863 aa)
csrACarbon storage regulator homolog; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Binds mRNA; 77% of enriched bound RNA is for flagellin A (flaA) while another 13% encodes other flagellar or motility-related genes. Binds mRNA in 5'-UTR or intergenic regions, binds consensus 5'-AAGGA-3' in the loop of a predicted stem-loop structure. Binds at least 2 sites in the 5'-UTR of flaA mRNA and represses its translation [...] (75 aa)
htrBOriginal (2000) note: Cj1134, htrB, probable lipid A biosynthesis lauroyl acyltransferase, len: 295 aa; similar to e.g. HTRB_ECOLI lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (306 aa), fasta scores; opt: 274 z-score: 340.3 E(): 1.2e-11, 23.4% identity in 299 aa overlap. 27.9% identity to HP0280; Updated (2006) note: Pfam domain PF03279 Bacterial lipid A biosynthesis acyltransferase domain was identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet, so putative kept within produc [...] (295 aa)
racRTwo-component regulator; Original (2000) note: Cj1261, racR, two-component regulator, len: 223 aa; identical to TR:O68795 (EMBL:AF053960) C. jejuni response regulator protein (223 aa), and similar to e.g. BAER_ECOLI transcriptional regulatory protein BAER (240 aa), fasta scores; opt: 485 z-score: 583.5 E(): 3.3e-25, 37.4% identity in 219 aa overlap. 52.0% identity to HP0166. Also simlar to Cj1227c (50.7% identity in 223 aa overlap). Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, and Pfam match to entry PF00486 trans_reg_C,Transcriptional regulato [...] (223 aa)
flaAFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA binds to flagellar assembly factor FliW protein, preventing FliW from binding to CsrA, so that CsrA can then bind flaA mRNA and represses its translation. (572 aa)
cadFOriginal (2000) note: Cj1478c, cadF, outer membrane fibronectin-binding protein, len: 319 aa; 82.8% identical to TR:O06895 (EMBL:U87559) C. jejuni CADF precursor (fibronectin-binding protein) (326 aa), and similar to many oprF proteins e.g. PORF_PSEFL outer membrane porin F precursor (root adhesin) (326 aa), fasta scores; opt: 401 z-score: 458.6 E(): 3.2e-18, 29.1% identity in 316 aa overlap. No Hp match. Contains PS01068 OmpA-like domain,and Pfam match to entry PF00691 OmpA, OmpA family; Updated (2006) note: Characterised within Campylobacter jejuni, so putative not added to product f [...] (319 aa)
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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