STRINGSTRING
moaA moaA trmU trmU Cj1349c Cj1349c Cj1386 Cj1386 Cj1433c Cj1433c Cj1501 Cj1501 Cj1505c Cj1505c moaD moaD moaE moaE prfA prfA thiS thiS Cj1633 Cj1633 moeB moeB Cj0883c Cj0883c Cj0834c Cj0834c Cj0725c Cj0725c Cj0602c Cj0602c Cj0519 Cj0519 Cj0294 Cj0294 moaC moaC iscS iscS Cj0239c Cj0239c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
moaAPutative molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (320 aa)
trmUPseudogene (putative sodium:sulfate transmembrane transport protein); Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (338 aa)
Cj1349cOriginal (2000) note: Cj1349c, possible fibronectin/fibrinogen-binding protein, len: aa; similar to TR:Q54858 (EMBL:L28919) Streptococcus pyogenes fibronectin/fibrinogen-binding protein FBP54 (474 aa),fasta scores; opt: 213 z-score: 230.0 E(): 1.7e-05, 23.2% identity in 466 aa overlap. 30.6% identity to HP1392; Updated (2006) note: Pfam domain PF05670 Domain of unknown function (DUF814) identified within CDS. No specific characterisation with acceptable identity score carried out yet, so putative kept within product function. Functional classification - Pathogenicity. (435 aa)
Cj1386Original (2000) note: Cj1386, ankyrin-repeat containing protein, len: 412 aa; similar to proteins downstream of catalase in Pseudomonads e.g. TR:P95546 (EMBL:U16026) Pseudomonas syringae ANKF precursor (183 aa), fasta scores; opt: 217 z-score: 286.8 E(): 1.2e-08,31.3% identity in 134 aa overlap, and to eukaryotic ankyrin proteins e.g. ANK1_MOUSE ankyrin (1862 aa), fasta scores; opt: 181 z-score: 226.3 E(): 2.8e-05, 29.1% identity in 117 aa overlap. No Hp match. Also similar to Cj0834c (29.3% identity in 99 aa overlap). Contains 2x Pfam match to entry PF00023 ank, Ank repeat; Updated (2 [...] (156 aa)
Cj1433cHypothetical protein Cj1433c; Original (2000) note: Cj1433c, unknown, len: 368 aa; no Hp match. Contains 9 repeats of the aa sequence KIDLNNT near the N-terminus; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Unknown; PMID:15612919, PMID:10672176. (368 aa)
Cj1501Conserved hypothetical protein Cj1501; Updated (2006) note: Conserved added to product function due to present motif within CDS; Original (2000) note: Cj1501, unknown, len: 85 aa; similar to hypothetical proteins e.g. YEDF_ECOLI (77 aa),fasta scores; opt: 341 z-score: 453.8 E(): 5.9e-18, 65.7% identity in 70 aa overlap. No Hp match. Contains PS01148 Uncharacterized protein family UPF0033 signature, and Pfam match to entry PF01206 UPF0033, Uncharacterized protein family UPF0033; Belongs to the sulfur carrier protein TusA family. (75 aa)
Cj1505cPutative two-component response regulator (SirA-like protein); Original (2000) note: Cj1505c, unknown, len: 190 aa; similar in N-term to hypothetical proteins e.g. Y990_METJA (75 aa), fasta scores; opt: 121 z-score: 164.1 E(): 0.081, 33.3% identity in 69 aa overlap. No Hp match. Some simlarity to Cj1492c (21.1% identity in 190 aa overlap). Contains Pfam match to entry PF01206 UPF0033,Uncharacterized protein family UPF0033; Updated (2006) note: Pfam domain PF01206 SirA-like protein identified within CDS. Product modified to more specific family member based on motif match. No specific c [...] (190 aa)
moaDOriginal (2000) note: Cj1517, moaD, possible molybdopterin converting factor, subunit 1, len: 73 aa; similar to many predicted moaD genes, e.g. TR:O31706 (EMBL:AF012285) Bacillus subtilis molybdopterin converting factor (subunit 1) (77 aa), fasta scores; opt: 111 z-score: 167.7 E(): 0.051, 30.5% identity in 59 aa overlap, and weakly similar to MOAD_ECOLI molybdopterin [mpt] converting factor, subunit 1 (81 aa), fasta scores; opt: 81 z-score: 127.5 E(): 8.8, 38.5% identity in 26 aa overlap. 61.6% identity to HP0801; Updated (2006) note: Pfam domain PF02597 ThiS family identified within [...] (73 aa)
moaEOriginal (2000) note: Cj1518, moaE, possible molybdopterin converting factor, subunit 2, len: 148 aa; similar to many predicted moaE genes, e.g. TR:O31705 (EMBL:AF012285) Bacillus subtilis molybdopterin converting factor (subunit 2) (157 aa), fasta scores; opt: 134 z-score: 182.4 E(): 0.0078, 25.2% identity in 131 aa overlap, and to MOAE_ECOLI molybdopterin [mpt] converting factor, subunit 2 (149 aa), fasta scores opt: 133 z-score: 181.4 E(): 0.0087, 26.0% identity in 123 aa overlap. 50.4% identity to HP0800; Updated (2006) note: Pfam domain PF02391 MoaE protein identified within CDS. [...] (148 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (355 aa)
thiSPutative thiamine biosynthesis protein; Original (2000) note: Cj1047c, unknown, len: 63 aa; similar to hypothetical proteins e.g. YC40_ODOSI (73 aa),fasta scores; opt: 131 z-score: 200.4 E(): 0.00072, 37.1% identity in 62 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02597 ThiS family identified within CDS. Product modified to a more specific family member based on motif match. Characterisation has been carried out within Escherichia coli and Bacillus subtilis with marginal simlilarity score. Putativae kept in product function. Functional classification - Biosynthesis of [...] (63 aa)
Cj1633Putative ATP-binding protein; Original (2000) note: Cj1633, unknown, len: 327 aa; similar to hypothetical proteins e.g. TR:O67046 (EMBL:AE000713) Aquifex aeolicus AQ_898 (251 aa), fasta scores; opt: 544 z-score: 648.2 E(): 8.8e-29, 50.2% identity in 221 aa overlap. 44.7% identity to HP0013. Contains HP0013; Updated (2006) note: Pfam domain PF01902 ATP-binding region identified within CDS. Product function modified to more specific family member based on motif match. Putative kept within product function. Functional classification - Conserved hypothetical proteins. (327 aa)
moeBOriginal (2000) note: Cj1046c, moeB, probable molybdopterin biosynthesis protein, len: 267 aa; similar to e.g. MOEB_ECOLI molybdopterin biosynthesis MOEB protein (249 aa), fasta scores; opt: 256 z-score: 309.6 E(): 6e-1,28.6% identity in 192 aa overlap. 34.2% identity to HP0814. Contains Pfam match to entry PF00899 ThiF_family; Updated (2006) note: Characterisation has been carried out in Escerichia coli, however, identity score was marginal, so putative kept in product function. Recent literature search has shown strong similarity with ThiF protein. Functional classification - Biosynt [...] (267 aa)
Cj0883cPutative transcriptional regulator; Original (2000) note: Cj0883c, unknown, len: 136 aa; identical to TR:Q46090 (EMBL:U06951) Campylobacter jejuni 81-176 ORF3 in region upstream of the flhA gene. (136 aa), and similar to hypothetical proteins e.g. Y379_HAEIN (150 aa), fasta scores; opt: 174 z-score: 226.5 E(): 2.6e-05, 28.3% identity in 138 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02082 Transcriptional regulator identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation carried out yet, so putative kept i [...] (136 aa)
Cj0834cOriginal (2000) note: Cj0834c, possible periplasmic protein, len: 412 aa; similar in C-terminus to ankyrin repeat-containing proteins e.g. ANKH_CHRVI ankyrin homolog precursor (323 aa), fasta scores; opt: 194 z-score: 229.9 E(): 1.7e-05, 28.9% identity in 194 aa overlap. No Hp match. Some similarity to ankyrin repeats in Cj1386 (29.3% identity in 99 aa overlap). Contains 2x Pfam match to entry PF00023 ank, Ank repeat, and possible N-terminal signal sequence; Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. Putative kept within product f [...] (412 aa)
Cj0725cMolybdopterin biosynthesis protein; Original (2000) note: Cj0725c, mog, probable molybdopterin biosynthesis protein, len: 180 aa; similar to e.g. MOG_ECOLI molybdopterin biosynthesis MOG protein (195 aa), fasta scores; opt: 506 z-score: 615.6 E(): 5.5e-27, 50.8% identity in 187 aa overlap. 65.3% identity to HP0799; Updated (2006) note: Pfam domain PF00994 Probable molybdopterin binding domain found within CDS. Characterised within Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors,prosthetic gro [...] (180 aa)
Cj0602cMOSC-domain containing protein; Original (2000) note: Cj0602c, unknown, len: 222 aa; similar to hypothetical proteins e.g. YIIM_ECOLI (234 aa), fasta scores; opt: 298 z-score: 406.4 E(): 2.4e-15,30.4% identity in 207 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF03475 3-alpha domain and PF03473 MOSC domain were identified within CDS. Product modified to more specific family member due to motif match. Functional classification - Misc. (222 aa)
Cj0519Putative rhodanese-like domain protein; Original (2000) note: Cj0519, unknown, len: 105 aa; similar to hypothetical proteins e.g. TR:E1342888 (EMBL:AJ235272) Rickettsia prowazekii RP600 (123 aa),fasta scores; opt: 151 z-score: 214.9 E(): 0.00011, 41.6% identity in 89 aa overlap. 34.3% identity to HP1223; Updated (2006) note: Prosite domain PS50206 RHODANESE_3, Rhodanese domain profile also identified within CDS. Rhodanese, a sulphurtransferase involved in cyanide detoxification shares evolutionary relationship with a large family of proteins. This domain is found as a single copy in ot [...] (105 aa)
Cj0294Putative MoeB/ThiF family protein; Original (2000) note: Cj0294, unknown, len: 219 aa; similar to members of the hesA/moeB/thiF family, e.g. YGDL_ECOLI (268 aa), fasta scores; opt: 219 z-score: 563.3 E(): 4e-24, 33.5% identity in 254 aa overlap. 48.3% identity to HP0755 (described as moeB). Contains Pfam match to entry PF00899 ThiF_family, ThiF family, score 33.10, E-value 2e-07. Also similar to Cj1046c (33.6% identity in 146 aa overlap); Updated (2006) note: No specific characterisation with acceptable identity scores carried out yet. Putative kept within product function. Functional [...] (219 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (157 aa)
iscSOriginal (2000) note: Cj0240c, probable aminotransferase (nifS protein homolog), len: 393 aa; similar to many e.g. NIFS_KLEPN nifS protein (397 aa),fasta scores; opt: 1067 z-score: 1533.6 E(): 0, 47.0% identity in 383 aa overlap. 62.8% identity to HP0220. Contains PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature, PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site, and Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V,score 358.80, E-value 5.9e-104; Updated (2006) note: Characterised within Escherichia coli with acceptable identity scor [...] (393 aa)
Cj0239cNifU protein homolog; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. (323 aa)
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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