STRINGSTRING
APY11072.1 APY11072.1 dapA dapA APY09738.1 APY09738.1 dapF dapF serC serC lysA lysA APY09997.1 APY09997.1 trpD trpD trpC trpC trpF trpF trpA trpA APY10122.1 APY10122.1 APY10159.1 APY10159.1 APY10237.1 APY10237.1 folD folD carA carA dapB dapB APY10557.1 APY10557.1 APY10704.1 APY10704.1 APY12774.1 APY12774.1 gltD gltD APY10796.1 APY10796.1 APY10822.1 APY10822.1 APY10915.1 APY10915.1 panD panD APY11319.1 APY11319.1 ilvD ilvD APY11360.1 APY11360.1 APY11361.1 APY11361.1 ilvC ilvC ilvA ilvA APY11367.1 APY11367.1 argC argC proC proC APY11370.1 APY11370.1 proA proA proB proB APY11373.1 APY11373.1 APY11375.1 APY11375.1 APY11376.1 APY11376.1 APY11443.1 APY11443.1 APY11447.1 APY11447.1 APY11460.1 APY11460.1 APY11461.1 APY11461.1 APY11462.1 APY11462.1 APY11463.1 APY11463.1 APY11470.1 APY11470.1 APY11471.1 APY11471.1 APY11472.1 APY11472.1 APY11700.1 APY11700.1 APY11705.1 APY11705.1 APY11961.1 APY11961.1 APY11992.1 APY11992.1 metE metE proC-2 proC-2 proB-2 proB-2 APY12083.1 APY12083.1 glyA glyA BWZ22_14175 BWZ22_14175 thrB thrB APY12299.1 APY12299.1 leuB leuB APY12354.1 APY12354.1 leuD leuD APY12356.1 APY12356.1 APY12402.1 APY12402.1 APY12443.1 APY12443.1 APY12554.1 APY12554.1 cysI cysI APY12569.1 APY12569.1 APY12587.1 APY12587.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APY11072.1Coproporphyrinogen III oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa)
APY09738.1GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (257 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (354 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (411 aa)
APY09997.1Asparagine synthase (glutamine-hydrolyzing); Derived by automated computational analysis using gene prediction method: Protein Homology. (569 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (330 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (261 aa)
trpFTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpF family. (607 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (254 aa)
APY10122.1Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (355 aa)
APY10159.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (340 aa)
APY10237.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (368 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (235 aa)
APY10557.1Peptidase dimerization domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
APY10704.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (439 aa)
APY12774.1Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1503 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
APY10796.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (416 aa)
APY10822.1ferredoxin-NADP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
APY10915.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (368 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa)
APY11319.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (561 aa)
APY11360.1Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology. (578 aa)
APY11361.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (421 aa)
APY11367.1Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (327 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa)
APY11370.1Aspartate aminotransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (374 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (398 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (254 aa)
APY11373.1Acetylornithine carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (312 aa)
APY11375.1Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
APY11376.1Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
APY11443.13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (370 aa)
APY11447.1Bifunctional aspartate kinase/homoserine dehydrogenase I; Derived by automated computational analysis using gene prediction method: Protein Homology. (1132 aa)
APY11460.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
APY11461.1Cysteine synthase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (296 aa)
APY11462.15-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
APY11463.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (890 aa)
APY11470.1Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
APY11471.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
APY11472.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
APY11700.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
APY11705.1Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
APY11961.12,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transferase hexapeptide repeat family. (271 aa)
APY11992.1Ornithine--oxo-acid transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (414 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (767 aa)
proC-2Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa)
proB-2Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (256 aa)
APY12083.1Aspartate aminotransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (400 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
BWZ22_14175Hypothetical protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa)
APY12299.1Bifunctional aspartate kinase/homoserine dehydrogenase I; Derived by automated computational analysis using gene prediction method: Protein Homology. (814 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (351 aa)
APY12354.12-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (199 aa)
APY12356.13-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
APY12402.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
APY12443.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
APY12554.1Sulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (600 aa)
cysISulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (565 aa)
APY12569.1FMN-binding glutamate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (520 aa)
APY12587.1Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
Your Current Organism:
Seonamhaeicola sp. S23
NCBI taxonomy Id: 1936081
Other names: S. sp. S2-3, Seonamhaeicola sp. S2-3
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