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| | dnaN | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa) |
| | nadD | Nicotinate-nucleotide adenyltransferase, putative; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (195 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (181 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (175 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (73 aa) |
| | atpB-2 | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (276 aa) |
| | bchU | C-20 methyltransferase; Involved in the biosynthesis of the major light-harvesting pigment bacteriochlorophyll c (BChlc), which confers a significant competitive advantage to green sulfur bacteria living at limiting red and near-infrared light intensities. Catalyzes the methylation at the C-20 position of the cyclic tetrapyrrole chlorin of bacteriochlorophyll d (BChld) to produce bacteriochlorophyll c (BChlc) using S-adenosylmethionine (SAM) as a methyl source. (338 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (508 aa) |
| | bioA | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (426 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (239 aa) |
| | bioC | Biotin synthesis protein, putative; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (260 aa) |
| | bioB | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (333 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit; Identified by similarity to EGAD:12602; match to protein family HMM PF00117; match to protein family HMM PF00988; match to protein family HMM TIGR01368; Belongs to the CarA family. (366 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (185 aa) |
| | nadK | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (283 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Identified by similarity to EGAD:24860; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878. (329 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Identified by similarity to EGAD:137466; match to protein family HMM PF00215; match to protein family HMM TIGR02127. (274 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (565 aa) |
| | nusG | Transcription antitermination protein NusG; Participates in transcription elongation, termination and antitermination. (191 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1303 aa) |
| | rpoC | DNA-directed RNA polymerase, beta-prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1490 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (334 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (516 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (458 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (356 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (511 aa) |
| | dfp | Pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa) |
| | nusA | N utilization substance protein A, putative; Participates in both transcription termination and antitermination. (521 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Identified by similarity to EGAD:91083; match to protein family HMM PF01687; match to protein family HMM PF06574; match to protein family HMM TIGR00083; Belongs to the ribF family. (321 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (195 aa) |
| | CT0248 | Hypothetical protein; Identified by Glimmer2; putative. (117 aa) |
| | folC | Folylpolyglutamate synthase; Identified by similarity to EGAD:18984; match to protein family HMM PF02875; match to protein family HMM TIGR01499. (392 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (429 aa) |
| | CT0278 | RNA polymerase sigma-70 factor, ECF subfamily; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; Belongs to the sigma-70 factor family. ECF subfamily. (178 aa) |
| | cmk | Cytidylate kinase; Identified by similarity to EGAD:6353; match to protein family HMM PF02224; match to protein family HMM TIGR00017. (235 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (177 aa) |
| | crtC | Hydroxyneurosporene synthase CrtC; Identified by similarity to EGAD:131985; match to protein family HMM PF07143; Belongs to the CrtC hydratase family. (382 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa) |
| | rfbD | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (292 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (497 aa) |
| | queE | Radical activating enzyme, putative; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (220 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (199 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to EGAD:22140; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. (523 aa) |
| | CT0322 | Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. (313 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (237 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (644 aa) |
| | PhhB | Pterin-4-alpha-carbinolamine dehydratase; Identified by similarity to EGAD:21838; match to protein family HMM PF01329. (111 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (175 aa) |
| | hemN | Oxygen-independent coproporphyrinogen III oxidase; Identified by match to protein family HMM PF04055; match to protein family HMM PF06969; match to protein family HMM TIGR00538; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (476 aa) |
| | cbiDJ | precorrin-6X reductase/cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (610 aa) |
| | cbiGF | Precorrin-4 C11-methyltransferase/cobalamin biosynthesis protein; Identified by similarity to EGAD:20657; similarity to GP:3724046; match to protein family HMM PF00590; match to protein family HMM PF01890; match to protein family HMM TIGR01465; Belongs to the precorrin methyltransferase family. (624 aa) |
| | cbiET | Precorrin-6y c5,15-methyltransferase, decarboxylating; Identified by similarity to EGAD:12801; match to protein family HMM PF00590; match to protein family HMM TIGR02467; match to protein family HMM TIGR02469. (400 aa) |
| | cbiCH | precorrin-3B C17-methyltransferase/precorrin-8X methylmutase; Identified by similarity to EGAD:15379; similarity to EGAD:17916; match to protein family HMM PF00590; match to protein family HMM PF02570; match to protein family HMM TIGR01466. (479 aa) |
| | cbiL | Precorrin-2 C20-methyltransferase; Identified by similarity to EGAD:18341; match to protein family HMM PF00590; Belongs to the precorrin methyltransferase family. (246 aa) |
| | CT0389 | Cobalt chelatase CbiK, putative; Identified by similarity to EGAD:16278; match to protein family HMM PF06180. (313 aa) |
| | cobA | uroporphyrin-III C-methyltransferase; Identified by similarity to EGAD:12949; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. (267 aa) |
| | cbiN | Cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (106 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (251 aa) |
| | CT0418 | cobN protein, putative; Identified by similarity to EGAD:15304; match to protein family HMM PF02514. (1259 aa) |
| | modD | Molybdenum transport system protein modD; Identified by similarity to EGAD:14831; match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR01334; Belongs to the NadC/ModD family. (285 aa) |
| | CT0466 | Hypothetical protein; Identified by Glimmer2; putative. (94 aa) |
| | CT0474 | Hydrogenase, putative; Identified by similarity to EGAD:16288. (281 aa) |
| | CT0502 | RNA polymerase sigma-70 factor, ECF subfamily; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | trpB-1 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (227 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | queA-1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (340 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (424 aa) |
| | nadE | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (277 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (531 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (322 aa) |
| | CT0578 | Ribonucleotide reductase family protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1129 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa) |
| | CT0648 | RNA polymerase sigma-70 factor, ECF subfamily; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; Belongs to the sigma-70 factor family. ECF subfamily. (198 aa) |
| | thiH | ThiH protein; Identified by similarity to EGAD:7866; match to protein family HMM PF04055; match to protein family HMM PF06968. (355 aa) |
| | thiG | ThiG protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa) |
| | trpF | N-(5'-phosphoribosyl)-anthranilate isomerase; Identified by similarity to EGAD:38562; match to protein family HMM PF00697; Belongs to the TrpF family. (221 aa) |
| | mtd | Methylenetetrahydrofolate dehydrogenase; Identified by similarity to EGAD:54210; match to protein family HMM PF00763; match to protein family HMM PF02882. (296 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (373 aa) |
| | CT0763 | Ferrochelatase, putative; Identified by similarity to EGAD:40051; Belongs to the ferrochelatase family. (355 aa) |
| | folE | GTP cyclohydrolase I; Identified by similarity to EGAD:42665; match to protein family HMM PF01227; match to protein family HMM TIGR00063. (224 aa) |
| | CT0782 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by similarity to EGAD:66078; match to protein family HMM PF01242. (149 aa) |
| | CT0800 | acetyl-CoA carboxylase, carboxyl transferase subunit alpha, putative; Identified by similarity to EGAD:29032. (348 aa) |
| | dnaE | DNA polymerase III, alpha subunit; Identified by similarity to EGAD:20624; match to protein family HMM PF01336; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (1190 aa) |
| | cbiA-1 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (459 aa) |
| | cbiP | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (500 aa) |
| | CT0939 | Aminotransferase, class II; Identified by match to protein family HMM PF00155. (369 aa) |
| | cbiB | Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa) |
| | btuR | cob(I)alamin adenosyltransferase; Identified by similarity to EGAD:20443; match to protein family HMM PF02572. (174 aa) |
| | cobP | Cobalamin biosynthesis protein CobP; Identified by similarity to EGAD:21537; match to protein family HMM PF02283. (172 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (353 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (267 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by similarity to EGAD:19545; match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. (235 aa) |
| | kdtB | Lipopolysaccharide core biosynthesis protein KdtB; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa) |
| | purB | Adenylosuccinate lyase; Identified by similarity to EGAD:15453; match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (434 aa) |
| | CT0995 | Conserved hypothetical protein; Identified by similarity to EGAD:48940; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF05368; match to protein family HMM PF07993. (292 aa) |
| | atpB-1 | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (221 aa) |
| | atpC-1 | ATP synthase F1, epsilon subunit; Identified by similarity to GP:1929514; match to protein family HMM PF02823. (129 aa) |
| | atpD-1 | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (480 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; Identified by similarity to EGAD:21587; match to protein family HMM PF00929; match to protein family HMM TIGR00573. (232 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (439 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa) |
| | CT1063 | Conserved hypothetical protein; Identified by similarity to EGAD:76752; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF05368; match to protein family HMM PF07993. (344 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (290 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (204 aa) |
| | thiD | Phosphomethylpyrimidine kinase; Identified by similarity to EGAD:90778; match to protein family HMM TIGR00097. (277 aa) |
| | CT1177 | Identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721. (445 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (811 aa) |
| | rpoN | RNA polymerase sigma-54 factor; Identified by similarity to EGAD:17014; match to protein family HMM PF04552; match to protein family HMM PF04963; match to protein family HMM TIGR02395. (484 aa) |
| | coaE | Kinase, putative; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (208 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (759 aa) |
| | hydG-2 | Hydrogenase/sulfur reductase, gamma subunit; Identified by similarity to GP:563906; match to protein family HMM PF00175. (278 aa) |
| | rfaD | ADP-L-glycero-D-mannoheptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (332 aa) |
| | chlG | Bacteriochlorophyll synthase, 34 kDa subunit; Identified by similarity to SP:P33326; match to protein family HMM PF01040; match to protein family HMM TIGR01476. (367 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa) |
| | bchH-3 | Magnesium-protoporphyrin methyltransferase; Identified by similarity to GP:2661856; match to protein family HMM PF02514; match to protein family HMM TIGR02025. (1271 aa) |
| | bchD | Magnesium-chelatase, subunit D; Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (620 aa) |
| | bchI | Magnesium-chelatase, subunit I; Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (392 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (214 aa) |
| | queA-2 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (346 aa) |
| | bchR | BchE/P-methylase family protein; Involved in the biosynthesis of the major light-harvesting pigment bacteriochlorophyll c (BChlc), which confers a significant competitive advantage to green sulfur bacteria living at limiting red and near-infrared light intensities. BchR is a methyltransferase that adds a single methyl group to the methyl carbon at the C-12(1) position of 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d to yield 8,12- diethyl-3-vinylbacteriochlorophyllide d; Belongs to the radical SAM superfamily. (456 aa) |
| | dnaZX | DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (620 aa) |
| | moaCB | Molybdenum cofactor biosynthesis protein CB; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); In the C-terminal section; belongs to the MoaB/Mog family. (312 aa) |
| | moeA | Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (426 aa) |
| | mobBA | Molybdopterin-guanine dinucleotide biosynthesis protein BA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (373 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (330 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (234 aa) |
| | purS | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (84 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (377 aa) |
| | coaX | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (270 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | bchF | 2-vinyl bacteriochlorophyllide hydratase; Identified by similarity to EGAD:8942; match to protein family HMM PF07284; match to protein family HMM TIGR02020. (158 aa) |
| | bchC | 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Identified by similarity to EGAD:9474; match to protein family HMM PF00107; match to protein family HMM TIGR01202. (337 aa) |
| | bchX | Chlorophyllide reductase, BchX subunit; Identified by similarity to EGAD:10210; match to protein family HMM PF00142; match to protein family HMM TIGR02016; Belongs to the NifH/BchL/ChlL family. (384 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (426 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (312 aa) |
| | hemD | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. (328 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (556 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (361 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa) |
| | CT1483 | Hypothetical protein; Identified by Glimmer2; putative. (220 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (410 aa) |
| | gpt | Hypoxanthine-guanine phosphoribosyltransferase; Identified by similarity to GP:3046326; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | thyX | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (219 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (278 aa) |
| | dnaG | DNA primase, putative; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (625 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (427 aa) |
| | carB2 | Carbamoyl-phosphate synthase, large subunit; Identified by similarity to EGAD:19159; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02786; match to protein family HMM PF02787; Belongs to the CarB family. (618 aa) |
| | pyrDI | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (305 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) |
| | bchG | Bacteriochlorophyll synthase, 34 kDa subunit; Identified by similarity to SP:P33326; match to protein family HMM PF01040; match to protein family HMM TIGR01476. (330 aa) |
| | CT2284 | Identified by match to protein family HMM PF00136; match to protein family HMM PF03104. (806 aa) |
| | bchP | Geranylgeranyl hydrogenase; Identified by similarity to EGAD:102228; match to protein family HMM PF01360; match to protein family HMM PF07992; match to protein family HMM TIGR02023; match to protein family HMM TIGR02032. (383 aa) |
| | CT2239 | Porphyrin biosynthesis protein, putative; Similar to N-terminal 140 aa of E. coli cysG (siroheme synthase) and adjacent to hemD, which is similar to the remainder of cysG; identified by similarity to EGAD:6104; match to protein family HMM TIGR01470. (157 aa) |
| | CT2238 | Siroheme synthetase, putative; Identified by similarity to EGAD:14346; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. (461 aa) |
| | atpC-2 | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (88 aa) |
| | atpD-2 | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (462 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (328 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (435 aa) |
| | bchN | Protochlorophyllide reductase, ChlN subunit; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex. (420 aa) |
| | bchB | Protochlorophyllide reductase, ChlB subunit; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex. (537 aa) |
| | bchL | Protochlorophyllide reductase, iron-sulfur ATP-binding protein; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP. (276 aa) |
| | bchZ | Chlorophyllide reductase, bchZ subunit; Identified by similarity to EGAD:8283; match to protein family HMM PF00148; match to protein family HMM PF06710; match to protein family HMM TIGR02014. (468 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase; Identified by similarity to EGAD:19989; match to protein family HMM PF00202; match to protein family HMM TIGR00713; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (431 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (351 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (526 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa) |
| | bchJ | Bacteriochlorophyll synthase, 23 kDa subunit; Identified by similarity to GP:3820550; match to protein family HMM TIGR02019. (191 aa) |
| | CT2010 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (375 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | bchK | Bacteriochlorophyll c synthase; Identified by similarity to SP:P33326; match to protein family HMM PF01040. (358 aa) |
| | bchM | Magnesium-protoporphyrin IX monomethyl ester oxidative cyclase, 25 kDa subunit; Identified by similarity to EGAD:8986; match to protein family HMM PF07109; match to protein family HMM TIGR02021. (232 aa) |
| | bchH-1 | Magnesium-protoporphyrin methyltransferase; Identified by similarity to EGAD:6772; match to protein family HMM PF02514; match to protein family HMM TIGR02025. (1278 aa) |
| | CT1955 | Magnesium-chelatase, bacteriochlorophyll c-specific subunit; Identified by similarity to GP:2661856; match to protein family HMM PF02514; match to protein family HMM TIGR02025. (1295 aa) |
| | CT1948 | Conserved hypothetical protein; Identified by similarity to EGAD:45801; match to protein family HMM PF06144; match to protein family HMM TIGR01128. (346 aa) |
| | pyrDII | Dihydroorotate dehydrogenase, electron transfer subunit; Identified by similarity to EGAD:16288; match to protein family HMM PF00970. (264 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine-pyrophosphokinase; Identified by similarity to EGAD:22732; match to protein family HMM PF01288; match to protein family HMM TIGR01498. (171 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Identified by similarity to EGAD:19234; match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR00078; Belongs to the NadC/ModD family. (300 aa) |
| | hydG-1 | Hydrogenase/sulfur reductase, gamma subunit; Identified by similarity to EGAD:32896; match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF08022. (274 aa) |
| | kpsU | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa) |
| | bchY | Chlorophyllide reductase, BchY subunit; Identified by similarity to EGAD:10229; match to protein family HMM PF00148; match to protein family HMM TIGR02015. (407 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa) |
| | pyrB | Aspartate carbamoyltransferase; Identified by similarity to EGAD:22412; match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00670; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa) |
| | bchQ | Bacteriochlorophyll c8 methyltransferase; Involved in the biosynthesis of the major light-harvesting pigment bacteriochlorophyll c (BChlc), which confers a significant competitive advantage to green sulfur bacteria living at limiting red and near-infrared light intensities. BchQ is a methyltransferase that adds two consecutive methyl groups to the ethyl carbon at the C-8(2) position of 8,12-diethyl-3-vinylbacteriochlorophyllide d to yield 12- ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d. (451 aa) |
| | CT1776 | Bacteriochlorophyll c3(1) hydratase; Identified by similarity to EGAD:8942; match to protein family HMM PF07284; match to protein family HMM TIGR02020. (190 aa) |
| | CT1712 | Para-aminobenzoate synthetase, putative; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553. (628 aa) |
| | nusB | N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (164 aa) |
| | folP | Dihydropteroate pyrophosphorylase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (304 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Identified by similarity to EGAD:7937; match to protein family HMM PF01071; match to protein family HMM PF02842; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877. (425 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Identified by similarity to EGAD:15617; match to protein family HMM PF00218; Belongs to the TrpC family. (256 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (950 aa) |
| | acs | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (621 aa) |
| | queF | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (117 aa) |
