(22 nodes) Alanine, aspartate and glutamate metabolism network (Chlorobaculum tepidum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	carA	Carbamoyl-phosphate synthase, small subunit; Identified by similarity to EGAD:12602; match to protein family HMM PF00117; match to protein family HMM PF00988; match to protein family HMM TIGR01368; Belongs to the CarA family. (366 aa)
	glmS	Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (614 aa)
	CT0282	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992. (582 aa)
	purF	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (497 aa)
	gltB	Glutamate synthase, large subunit; Identified by similarity to EGAD:109137; similarity to EGAD:134205; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898. (1538 aa)
	gltD-2	Glutamate synthase, small subunit; Identified by similarity to EGAD:142506; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01317. (490 aa)
	gltD-1	Glutamate synthase, small subunit; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01316. (472 aa)
	nadB	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (531 aa)
	CT0650	Identified by similarity to EGAD:16142; match to protein family HMM PF01262; match to protein family HMM PF05222. (377 aa)
	ald	Alanine dehydrogenase; Identified by similarity to EGAD:16141; match to protein family HMM PF01262; match to protein family HMM PF05222; match to protein family HMM TIGR00518; Belongs to the AlaDH/PNT family. (380 aa)
	CT0966	Aspartate aminotransferase, putative; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate. (400 aa)
	purB	Adenylosuccinate lyase; Identified by similarity to EGAD:15453; match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (434 aa)
	argH	Argininosuccinate lyase; Identified by similarity to EGAD:11709; match to protein family HMM PF00206; match to protein family HMM TIGR00838. (463 aa)
	argG	Argininosuccinate synthase; Identified by similarity to EGAD:39789; match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa)
	purQ	Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (234 aa)
	glnA	Glutamine synthetase; Identified by similarity to EGAD:21008; match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (714 aa)
	CT1573	Identified by match to protein family HMM PF00171. (457 aa)
	carB2	Carbamoyl-phosphate synthase, large subunit; Identified by similarity to EGAD:19159; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02786; match to protein family HMM PF02787; Belongs to the CarB family. (618 aa)
	carB1	Carbamoyl-phosphate synthase, medium subunit; Identified by similarity to EGAD:19159; match to protein family HMM PF00289; match to protein family HMM PF02786; match to protein family HMM PF02787; Belongs to the CarB family. (494 aa)
	pyrB	Aspartate carbamoyltransferase; Identified by similarity to EGAD:22412; match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00670; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
	gdhA	Glutamate dehydrogenase; Identified by similarity to EGAD:22862; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (418 aa)
	purA	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (435 aa)

Your Current Organism:

Chlorobaculum tepidum

NCBI taxonomy Id: 194439
Other names: C. tepidum TLS, Chlorobaculum tepidum TLS, Chlorobium tepidum TLS

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CT0282	CT0966	CT0282	CT0966	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Aspartate aminotransferase, putative; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate.	0.916
CT0282	CT1573	CT0282	CT1573	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Identified by match to protein family HMM PF00171.	0.466
CT0282	carA	CT0282	CT0066	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Carbamoyl-phosphate synthase, small subunit; Identified by similarity to EGAD:12602; match to protein family HMM PF00117; match to protein family HMM PF00988; match to protein family HMM TIGR01368; Belongs to the CarA family.	0.905
CT0282	carB1	CT0282	CT1672	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Carbamoyl-phosphate synthase, medium subunit; Identified by similarity to EGAD:19159; match to protein family HMM PF00289; match to protein family HMM PF02786; match to protein family HMM PF02787; Belongs to the CarB family.	0.924
CT0282	carB2	CT0282	CT1592	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Carbamoyl-phosphate synthase, large subunit; Identified by similarity to EGAD:19159; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02786; match to protein family HMM PF02787; Belongs to the CarB family.	0.924
CT0282	gdhA	CT0282	CT2023	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Glutamate dehydrogenase; Identified by similarity to EGAD:22862; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.943
CT0282	glmS	CT0282	CT0130	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.921
CT0282	glnA	CT0282	CT1411	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Glutamine synthetase; Identified by similarity to EGAD:21008; match to protein family HMM PF00120; Belongs to the glutamine synthetase family.	0.905
CT0282	gltB	CT0282	CT0401	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Glutamate synthase, large subunit; Identified by similarity to EGAD:109137; similarity to EGAD:134205; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898.	0.999
CT0282	gltD-1	CT0282	CT0473	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Glutamate synthase, small subunit; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01316.	0.919
CT0282	gltD-2	CT0282	CT0402	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Glutamate synthase, small subunit; Identified by similarity to EGAD:142506; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01317.	0.925
CT0282	purF	CT0282	CT0313	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.906
CT0282	purQ	CT0282	CT1338	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]	0.900
CT0650	ald	CT0650	CT0706	Identified by similarity to EGAD:16142; match to protein family HMM PF01262; match to protein family HMM PF05222.	Alanine dehydrogenase; Identified by similarity to EGAD:16141; match to protein family HMM PF01262; match to protein family HMM PF05222; match to protein family HMM TIGR00518; Belongs to the AlaDH/PNT family.	0.912
CT0650	gltB	CT0650	CT0401	Identified by similarity to EGAD:16142; match to protein family HMM PF01262; match to protein family HMM PF05222.	Glutamate synthase, large subunit; Identified by similarity to EGAD:109137; similarity to EGAD:134205; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898.	0.518
CT0966	CT0282	CT0966	CT0282	Aspartate aminotransferase, putative; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate.	Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992.	0.916
CT0966	argG	CT0966	CT1114	Aspartate aminotransferase, putative; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate.	Argininosuccinate synthase; Identified by similarity to EGAD:39789; match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily.	0.921
CT0966	gdhA	CT0966	CT2023	Aspartate aminotransferase, putative; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate.	Glutamate dehydrogenase; Identified by similarity to EGAD:22862; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.910
CT0966	gltB	CT0966	CT0401	Aspartate aminotransferase, putative; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate.	Glutamate synthase, large subunit; Identified by similarity to EGAD:109137; similarity to EGAD:134205; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898.	0.951
CT0966	gltD-1	CT0966	CT0473	Aspartate aminotransferase, putative; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate.	Glutamate synthase, small subunit; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01316.	0.903