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| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (222 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | tyrA | Prephenate dehydrogenase; Identified by similarity to EGAD:8704; match to protein family HMM PF02153; match to protein family HMM PF03446. (288 aa) |
| | lysC | Aspartokinase; Identified by similarity to EGAD:9629; match to protein family HMM PF00696; match to protein family HMM PF01842; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (470 aa) |
| | eno-2 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (437 aa) |
| | serB | Phosphoserine phosphatase; Identified by similarity to EGAD:8936; match to protein family HMM PF00702; match to protein family HMM PF01842; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. (407 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (458 aa) |
| | pfk-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (390 aa) |
| | CT0282 | Glutamate synthase, small subunit, putative; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992. (582 aa) |
| | icd | Isocitrate dehydrogenase, NADP-dependent, monomeric type; Identified by similarity to EGAD:40125; match to protein family HMM PF03971; match to protein family HMM TIGR00178; Belongs to the monomeric-type IDH family. (741 aa) |
| | argD | Acetylornithine aminotransferase; Identified by similarity to EGAD:102397; match to protein family HMM PF00202; match to protein family HMM TIGR00707; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa) |
| | gpm | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (247 aa) |
| | gltB | Glutamate synthase, large subunit; Identified by similarity to EGAD:109137; similarity to EGAD:134205; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898. (1538 aa) |
| | gltD-2 | Glutamate synthase, small subunit; Identified by similarity to EGAD:142506; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01317. (490 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (137 aa) |
| | gltD-1 | Glutamate synthase, small subunit; Identified by similarity to EGAD:37434; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01316. (472 aa) |
| | hisH | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to GP:6175607; match to protein family HMM PF00977; match to protein family HMM TIGR00007. (260 aa) |
| | trpB-1 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | MetK | S-adenosylmethionine synthase, archaeal-type; Identified by similarity to EGAD:171913; match to protein family HMM PF01941. (404 aa) |
| | acn | Aconitate hydratase; Identified by similarity to EGAD:8034; match to protein family HMM PF00330; match to protein family HMM PF06434; match to protein family HMM TIGR00117; Belongs to the aconitase/IPM isomerase family. (854 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa) |
| | met2 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (356 aa) |
| | leuA-1 | 2-isopropylmalate synthase; Identified by similarity to EGAD:32071; match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa) |
| | CT0613 | 3-isopropylmalate dehydratase, small subunit, putative; Identified by match to protein family HMM PF00694; match to protein family HMM TIGR02087; Belongs to the LeuD family. (190 aa) |
| | CT0614 | 3-isopropylmalate dehydratase, large subunit, putative; Identified by match to protein family HMM PF00330; match to protein family HMM TIGR01343; match to protein family HMM TIGR02086; Belongs to the aconitase/IPM isomerase family. (431 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (352 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | ilvN | Acetolactate synthase, small subunit; Identified by similarity to GP:5733116; match to protein family HMM PF01842; match to protein family HMM TIGR00119. (159 aa) |
| | ilvB | Acetolactate synthase, large subunit; Identified by similarity to EGAD:156267; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. (573 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (560 aa) |
| | cysK | Cysteine synthase; Identified by similarity to EGAD:101752; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139. (310 aa) |
| | CT0701 | Identified by match to protein family HMM PF01053. (380 aa) |
| | trpF | N-(5'-phosphoribosyl)-anthranilate isomerase; Identified by similarity to EGAD:38562; match to protein family HMM PF00697; Belongs to the TrpF family. (221 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (376 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to SP:P06987; match to protein family HMM PF00475. (194 aa) |
| | CT0804 | Transketolase, C-terminal subunit; Identified by match to protein family HMM PF02779; match to protein family HMM PF02780. (327 aa) |
| | oadA | Oxaloacetate decarboxylase, alpha subunit; Identified by similarity to EGAD:22726; match to protein family HMM PF00364; match to protein family HMM PF00682. (627 aa) |
| | CT0939 | Aminotransferase, class II; Identified by match to protein family HMM PF00155. (369 aa) |
| | CT0963 | Transketolase, N-terminal subunit; Identified by match to protein family HMM PF00456. (303 aa) |
| | CT0966 | Aspartate aminotransferase, putative; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate. (400 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (353 aa) |
| | rpiB | Ribose-5-phosphate isomerase; Identified by similarity to EGAD:16338; match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (144 aa) |
| | fbaA | Fructose-bisphosphate aldolase, class II; Identified by similarity to EGAD:43086; match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (323 aa) |
| | argH | Argininosuccinate lyase; Identified by similarity to EGAD:11709; match to protein family HMM PF00206; match to protein family HMM TIGR00838. (463 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (341 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (404 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (285 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (338 aa) |
| | argG | Argininosuccinate synthase; Identified by similarity to EGAD:39789; match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Identified by similarity to EGAD:10126; similarity to EGAD:156515; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (348 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (191 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (368 aa) |
| | glnA | Glutamine synthetase; Identified by similarity to EGAD:21008; match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (714 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (397 aa) |
| | cysE | Serine acetyltransferase; Identified by similarity to EGAD:8839; similarity to EGAD:9562; match to protein family HMM PF00132; match to protein family HMM PF06426; match to protein family HMM TIGR01172. (273 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (245 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (361 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa) |
| | gapA | Glyceraldehyde 3-phosphate dehydrogenase; Identified by similarity to EGAD:13804; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | hisF | hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | pabA | Para-aminobenzoate/anthranilate synthase glutamine amidotransferase; Identified by similarity to EGAD:15632; match to protein family HMM PF00117; match to protein family HMM TIGR00566. (187 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (440 aa) |
| | pfk-1 | Phosphofructokinase; Identified by similarity to SP:O08333; match to protein family HMM PF00365. (401 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (303 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | pheA | Prephenate dehydratase; Identified by similarity to EGAD:20539; match to protein family HMM PF00800; match to protein family HMM PF01842. (280 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Identified by similarity to EGAD:101737; match to protein family HMM PF00215; match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Identified by similarity to EGAD:15617; match to protein family HMM PF00218; Belongs to the TrpC family. (256 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (295 aa) |
| | gltA | Citrate synthase; Identified by similarity to EGAD:20399; similarity to EGAD:77210; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family. (447 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (249 aa) |
| | metH | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1228 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (688 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa) |
| | CT1921 | Cysteine synthase/cystathionine beta-synthase family protein; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571. (456 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | eno-1 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (293 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (257 aa) |
| | ThrA | Aspartokinase/homoserine dehydrogenase; Identified by similarity to EGAD:9487; similarity to EGAD:75016; match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657. (818 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (324 aa) |
| | thrC | Threonine synthase; Identified by similarity to EGAD:7615; similarity to EGAD:16850; match to protein family HMM PF00291; match to protein family HMM TIGR00260. (441 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (562 aa) |
| | CT2212 | Acetyltransferase, GNAT family; Identified by match to protein family HMM PF00583; Belongs to the acetyltransferase family. (155 aa) |
| | pgk | Phosphoglycerate kinase; Identified by similarity to EGAD:81744; match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (397 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Identified by similarity to EGAD:19648; match to protein family HMM PF00132; Belongs to the transferase hexapeptide repeat family. (286 aa) |
