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| | purH | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Region:COG0138F. (536 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa) |
| | APG92965.1 | AMP-dependent synthetase and ligase; Region:COG0365I. (635 aa) |
| | holA | DNA polymerase III subunit delta; Region:COG1466L. (344 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (421 aa) |
| | hemE | Uroporphyrinogen decarboxylase HemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (344 aa) |
| | APG92976.1 | Protoporphyrinogen IX oxidase, HemJ; Region:COG1981S. (179 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa) |
| | coaE | dephospho-CoA kinase CoaE; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (177 aa) |
| | dnaQ | DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (232 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase TrpF; Region:COG0135E; Belongs to the TrpF family. (224 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (304 aa) |
| | folC | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase FolC; Region:COG0285H; Belongs to the folylpolyglutamate synthase family. (447 aa) |
| | coaA | Pantothenate kinase CoaA; Region:COG1072H. (331 aa) |
| | punA | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (265 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | APG89456.1 | Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (324 aa) |
| | dnaX | DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (625 aa) |
| | pheA | Prephenate dehydratase; Region:COG0077E. (284 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (1004 aa) |
| | APG89531.1 | Glyoxalase/bleomycin resistance protein/dioxygenase; Region:COG0346Q. (141 aa) |
| | nusA | Transcription elongation protein NusA; Participates in both transcription termination and antitermination. (536 aa) |
| | cmk | Cytidylate kinase; Region:COG0283F. (211 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (448 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa) |
| | queG | Electron transport protein YjeS; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (391 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (234 aa) |
| | dnaN | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (156 aa) |
| | APG89686.1 | NAD-dependent epimerase/dehydratase; Region:COG0451M. (327 aa) |
| | coaB | Coenzyme A biosynthesis bifunctional phosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa) |
| | APG89708.1 | RNA polymerase sigma-70 factor; Region:COG4941K; Belongs to the sigma-70 factor family. (424 aa) |
| | APG89712.1 | Oxygen-independent coproporphyrinogen-III oxidase-like protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (394 aa) |
| | rpoN | RNA polymerase sigma-54 factor RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (520 aa) |
| | cya-3 | Adenylate cyclase; Region:COG2114T. (623 aa) |
| | pyrC | Dihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (345 aa) |
| | pyrE | Orotate phosphoribosyltransferase PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (232 aa) |
| | APG89827.1 | UDP-galactose-lipid carrier transferase; Region:COG2326C. (300 aa) |
| | apaG | Protein ApaG; Region:COG2967P. (133 aa) |
| | pyrD | Dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (362 aa) |
| | APG89878.1 | Isochorismate pyruvate-lyase; Region:COG1605E. (101 aa) |
| | pncA | Pyrazinamidase/nicotinamidase PncA; Region:COG1335HR. (199 aa) |
| | pncB | Nicotinate phosphoribosyltransferase PncB; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (434 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (430 aa) |
| | APG89920.1 | ECF subfamily RNA polymerase sigma-24 subunit; Region:COG1595K; Belongs to the sigma-70 factor family. ECF subfamily. (180 aa) |
| | APG89945.1 | PhnB protein; Region:COG2764R. (148 aa) |
| | fliI | Flagellum-specific ATP synthase FliI; Region:COG1157NU. (466 aa) |
| | folD | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (299 aa) |
| | acsA | Acetoacetyl-coenzyme A synthetase AcsA; Region:COG0365I. (650 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (519 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Region:COG0196H; Belongs to the ribF family. (327 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (250 aa) |
| | atpE | ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpF | F0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (205 aa) |
| | atpF-2 | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (161 aa) |
| | purD | Phosphoribosylamine--glycine ligase PurD; Region:COG0151F; Belongs to the GARS family. (423 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (645 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase PdxH; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (206 aa) |
| | aroC | Chorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | ctaB | Protoheme IX farnesyltransferase CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (360 aa) |
| | APG90290.1 | Hypothetical protein; Region:COG1678K; Belongs to the UPF0301 (AlgH) family. (197 aa) |
| | amn | AMP nucleosidase Amn; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (500 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (134 aa) |
| | rkpK | UDP-glucose 6-dehydrogenase RkpK; Region:COG1004M. (437 aa) |
| | lspL | UDP-glucuronate 5'-epimerase LspL; Region:COG0451M. (341 aa) |
| | nadB | L-aspartate oxidase NadB; Catalyzes the oxidation of L-aspartate to iminoaspartate. (532 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Region:COG0157H; Belongs to the NadC/ModD family. (300 aa) |
| | APG90481.1 | Hydrolase protein; Region:COG1896FR. (202 aa) |
| | purF | Amidophosphoribosyltransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (497 aa) |
| | dnaB | Replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (499 aa) |
| | gmk | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (203 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (342 aa) |
| | APG90531.1 | DNA polymerase III chi subunit HolC; Region:COG2927L. (149 aa) |
| | ndk | Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (221 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase PurM; Region:COG0150F. (356 aa) |
| | APG90593.1 | Xanthine dehydrogenase YagR molybdenum-binding subunit YagR; Region:COG1529C. (738 aa) |
| | nusB | N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (160 aa) |
| | hemN | Oxygen-independent coproporphyrinogen-III oxidase HemN; Region:COG0635H; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (450 aa) |
| | ctaA | Heme A synthase HAS, Cytochrome aa3-controlling protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (367 aa) |
| | dnaE | DNA polymerase III subunit alpha; Region:COG0587L. (1164 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (429 aa) |
| | pyrC-2 | Dihydroorotase PyrC; Region:COG0044F. (430 aa) |
| | pyrB | Aspartate carbamoyltransferase PyrB; Region:COG0540F; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | ppnK | Inorganic polyphosphate/ATP-NAD kinase PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (256 aa) |
| | APG90765.1 | UDP-glucose 4-epimerase; Region:COG0451M. (299 aa) |
| | nusG | Transcription antitermination protein NusG; Participates in transcription elongation, termination and antitermination. (176 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1380 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1401 aa) |
| | adk | Adenylate kinase Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (336 aa) |
| | folE | GTP cyclohydrolase; Region:COG0302H. (205 aa) |
| | pyrG | CTP synthase PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (455 aa) |
| | flaR | Topology modulation protein; Region:COG0563F. (187 aa) |
| | cinA | Competence/damage-inducible protein CinA; Region:COG1546H; Belongs to the CinA family. (165 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (485 aa) |
| | pyrH | Uridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | serS | serine--tRNA ligase SerS; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa) |
| | trpC | Indole-3-glycerol phosphate synthase TrpC; Region:COG0134E; Belongs to the TrpC family. (271 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | gpt | Xanthine phosphoribosyltransferase Gpt; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa) |
| | APG91048.1 | Molybdenum cofactor biosynthesis protein; Region:COG1058R. (251 aa) |
| | purB | Adenylosuccinate lyase PurB; Region:COG0015F; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | nrdJ | Vitamin B12-dependent ribonucleotide reductase NrdJ; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1261 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Region:COG0458EF; Belongs to the CarB family. (1186 aa) |
| | coaD | Phosphopantetheine adenylyltransferase CoaD; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase QueA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (361 aa) |
| | tgt | Queuine tRNA-ribosyltransferase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to fo [...] (376 aa) |
| | APG91271.1 | Glutamate-rich protein grpB; Region:COG2320R. (168 aa) |
| | APG91280.1 | DNA polymerase III subunit delta; Region:COG0470L. (343 aa) |
| | tmk | Thymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (233 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Region:COG0152F; Belongs to the SAICAR synthetase family. (254 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (80 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (742 aa) |
| | APG91293.1 | BolA family protein; Region:COG0271T; Belongs to the BolA/IbaG family. (77 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Region:COG0801H. (180 aa) |
| | folB | Dihydroneopterin aldolase FolB; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa) |
| | sul | Dihydropteroate synthase Sul; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (290 aa) |
| | hemF | coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (303 aa) |
| | bluB | Nitroreductase, BluB-like protein; Region:COG0778C. (253 aa) |
| | nadE | Glutamine-dependent NAD(+) synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (560 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase AroH; Region:COG3200E. (459 aa) |
| | APG91386.1 | Hypothetical protein; Region:COG5425S. (84 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase CobT; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (338 aa) |
| | cobV | Cobalamin synthase CobV; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (262 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (326 aa) |
| | cobC | Threonine-phosphate decarboxylase CobC; Region:COG0079E. (335 aa) |
| | cobB | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (431 aa) |
| | cobA | uroporphyrinogen-III C-methyltransferase CobA; Region:COG0007H; Belongs to the precorrin methyltransferase family. (278 aa) |
| | cobE | CobE protein CobE. (152 aa) |
| | cobO | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (214 aa) |
| | cobN | Aerobic cobaltochelatase subunit CobN; Region:COG1429H. (1284 aa) |
| | cobW | Protein CobW; Region:COG0523R. (354 aa) |
| | cobP | Bifunctional adenosylcobalamin biosynthesis protein CobP; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (175 aa) |
| | cya-11 | Adenylate cyclase; Region:COG2114T. (747 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (484 aa) |
| | rpoN-2 | RNA polymerase sigma factor; Region:COG1595K; Belongs to the sigma-70 factor family. ECF subfamily. (175 aa) |
| | APG91521.1 | Guanylate/adenylate cyclase; Region:COG2114T. (469 aa) |
| | APG91523.1 | Pyrimidine reductase protein; Region:COG0262H. (219 aa) |
| | pta | Phosphate acetyltransferase; Region:COG0280C. (318 aa) |
| | ackA | Acetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa) |
| | cya-16 | Adenylate cyclase; Region:COG2114T. (307 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (250 aa) |
| | cya-17 | Adenylate cyclase; Region:COG1672R. (1024 aa) |
| | APG91663.1 | ECF family sigma factor; Region:COG1595K; Belongs to the sigma-70 factor family. ECF subfamily. (182 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (179 aa) |
| | thyA | Thymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase MurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (463 aa) |
| | APG91827.1 | Lactoylglutathione lyase; Region:COG0346Q. (116 aa) |
| | APG91863.1 | Hypothetical protein. (431 aa) |
| | APG91876.1 | tRNA-Met-CAT. (502 aa) |
| | APG91880.1 | RecG-like helicase; Region:COG3631R. (134 aa) |
| | rpoD | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (684 aa) |
| | dnaG | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (662 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Region:COG0505EF; Belongs to the CarA family. (401 aa) |
| | APG91898.1 | Hypothetical protein. (111 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | apt | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (197 aa) |
| | rpoE | ECF subfamily RNA polymerase sigma-24 subunit; Region:COG1595K; Belongs to the sigma-70 factor family. ECF subfamily. (172 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase QueF; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (154 aa) |
| | trpE | Anthranilate synthase; Region:COG0147EH. (729 aa) |
| | tdk | Thymidine kinase Tdk; Region:COG1435F. (195 aa) |
| | rfbG | CDP-glucose 4,6-dehydratase; Region:COG0451M. (356 aa) |
| | rmlC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (177 aa) |
| | sig | RNA polymerase sigma factor; Region:COG1595K; Belongs to the sigma-70 factor family. ECF subfamily. (183 aa) |
| | preA | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA; Region:COG0167F. (437 aa) |
| | cya-19 | Adenylate cyclase; Region:COG0633C. (557 aa) |
| | dht | D-hydantoinase/dihydropyrimidinase Dht; Region:COG0044F. (484 aa) |
| | APG92219.1 | Hypothetical protein; Region:COG4961UW. (532 aa) |
| | APG92250.1 | O-methyltransferase; Region:COG0500QR. (296 aa) |
| | APG92251.1 | Bifunctional deaminase/reductase-like protein; Region:COG0262H. (181 aa) |
| | APG92268.1 | acetyl-CoA synthetase; Region:COG0365I. (548 aa) |
| | cobO-2 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Region:COG2096H; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa) |
| | hpt | Hypoxanthine-guanine phosphoribosyltransferase Hpt; Region:COG0634F; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | tyrC | Cyclohexadienyl dehydrogenase; Region:COG0287E. (308 aa) |
| | APG92304.1 | preQ0 transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (212 aa) |
| | cobT-2 | Aerobic cobaltochelatase subunit CobT; Region:COG4547H. (630 aa) |
| | APG92309.1 | Cell division protein BolA; Region:COG0271T; Belongs to the BolA/IbaG family. (93 aa) |
| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (376 aa) |
| | aroK | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (195 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | APG92320.1 | GTP-binding protein YjiA; Region:COG0523R. (379 aa) |
| | APG92343.1 | UDP-glucose epimerase YtcB; Region:COG0451M. (346 aa) |
| | rfbE | CDP-paratose 2-epimerase RfbE; Region:COG0451M. (364 aa) |
| | APG92359.1 | Regulatory protein; Region:COG2326C. (306 aa) |
| | cya-21 | Adenylate cyclase; Region:COG2114T. (243 aa) |
| | rpoH | RNA polymerase sigma-32 factor RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (301 aa) |
| | purA | Adenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | ligD | ATP-dependent DNA ligase. (254 aa) |
| | APG92421.1 | ATP-dependent DNA ligase YkoU. (328 aa) |
| | sqdB | UDP-sulfoquinovose synthase SqdB; Region:COG0451M. (406 aa) |
| | APG92425.1 | UDP-glucose 4-epimerase; Region:COG0451M. (305 aa) |
| | APG92436.1 | 5-formyltetrahydrofolate cyclo-ligase; Region:COG0212H; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (190 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase ThiE; Region:COG0352H. (217 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa) |
| | purK | N5-carboxyaminoimidazole ribonucleotide synthase PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (349 aa) |
| | pabB | Para-aminobenzoate synthase component 1; Region:COG0147EH. (385 aa) |
| | hemH | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (349 aa) |
| | cya-24 | Adenylate cyclase; Region:COG2114T. (406 aa) |
| | APG92558.1 | Cobalamin synthesis protein/P47K family protein; Region:COG0523R. (368 aa) |
| | lig | DNA ligase Lig; Region:COG1793L. (537 aa) |
| | cobM | Precorrin-4 C(11)-methyltransferase CobM; Region:COG2875H; Belongs to the precorrin methyltransferase family. (252 aa) |
| | cobL | precorrin-6Y C(5,15)-methyltransferase; Region:COG2241H. (413 aa) |
| | cobK | precorrin-6A reductase CobK; Region:COG2099H. (266 aa) |
| | cobJ | precorrin-3B C(17)-methyltransferase CobJ; Region:COG1010H. (254 aa) |
| | cobI | Precorrin-2 C(20)-methyltransferase CobI; Region:COG2243H; Belongs to the precorrin methyltransferase family. (246 aa) |
| | cobH | precorrin-8X methylmutase CobH; Region:COG2082H. (210 aa) |
| | cobF | precorrin-6A synthase; Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. (256 aa) |
| | purU | Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) |
| | cutL | Carbon monoxide dehydrogenase; Region:COG1529C. (781 aa) |
| | APG92698.1 | Hypothetical protein; Region:COG2764R. (159 aa) |
| | atpC | ATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (136 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (493 aa) |
| | atpG | ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (293 aa) |
| | atpA | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (509 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (188 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (734 aa) |
| | hemC | Porphobilinogen deaminase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa) |
| | hemD | uroporphyrinogen-III synthase protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (234 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase NadD; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (202 aa) |
| | dnaE-2 | Error-prone DNA polymerase DnaE; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1117 aa) |
| | phhB | Pterin-4-alpha-carbinolamine dehydratase; Region:COG2154H. (105 aa) |
| | APG92881.1 | Thiamine pyrophosphokinase; Region:COG1564H. (216 aa) |
| | rpoH-2 | RNA polymerase sigma-32 factor RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (288 aa) |
| | pdxY | Pyridoxamine kinase PdxY; Region:COG2240H; Belongs to the pyridoxine kinase family. (293 aa) |
