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| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (376 aa) |
| | cobT-2 | Aerobic cobaltochelatase subunit CobT; Region:COG4547H. (630 aa) |
| | APG92304.1 | preQ0 transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (212 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase; Region:COG0079E; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa) |
| | tyrC | Cyclohexadienyl dehydrogenase; Region:COG0287E. (308 aa) |
| | hpt | Hypoxanthine-guanine phosphoribosyltransferase Hpt; Region:COG0634F; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa) |
| | argH | Argininosuccinate lyase ArgH; Region:COG0165E. (467 aa) |
| | cobO-2 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Region:COG2096H; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa) |
| | argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa) |
| | ubiG | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (248 aa) |
| | APG92251.1 | Bifunctional deaminase/reductase-like protein; Region:COG0262H. (181 aa) |
| | lysC | Aspartokinase LysC; Region:COG0527E; Belongs to the aspartokinase family. (424 aa) |
| | adhA-3 | Alcohol dehydrogenase; Region:COG1064G. (349 aa) |
| | amaB-2 | Amidase, hydantoinase/carbamoylase; Region:COG0624E. (412 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa) |
| | bioF-2 | 8-amino-7-oxononanoate synthase BioF; Region:COG0156H. (380 aa) |
| | bioD | ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (212 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Region:COG0161H; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | fabH-2 | 3-oxoacyl-ACP synthase; Region:COG0332I. (329 aa) |
| | amaB | N-carbamoyl-L-amino acid hydrolase AmaB; Region:COG0624E. (416 aa) |
| | preT | NAD-dependent dihydropyrimidine dehydrogenase subunit PreT; Region:COG0493ER. (453 aa) |
| | APG92045.1 | SAM-dependent methyltransferase; Region:COG2227H. (410 aa) |
| | APG91979.1 | Omega-amino acid--pyruvate aminotransferase; Region:COG0161H; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa) |
| | trpE | Anthranilate synthase; Region:COG0147EH. (729 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase QueF; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (154 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (587 aa) |
| | apt | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (197 aa) |
| | APG91915.1 | Hypothetical protein; Region:COG2960S. (94 aa) |
| | proC-2 | Pyrroline-5-carboxylate reductase ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Region:COG0505EF; Belongs to the CarA family. (401 aa) |
| | kbl | 2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa) |
| | APG91827.1 | Lactoylglutathione lyase; Region:COG0346Q. (116 aa) |
| | ribH-2 | 6,7-dimethyl-8-ribityllumazine synthase 2; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (157 aa) |
| | glnA-2 | Glutamine synthetase; Region:COG0174E; Belongs to the glutamine synthetase family. (454 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Region:COG0685E; Belongs to the methylenetetrahydrofolate reductase family. (310 aa) |
| | panC | Pantothenate synthetase PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (291 aa) |
| | folD | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (299 aa) |
| | puuA | Gamma-glutamylputrescine synthetase PuuA; Region:COG0174E; Belongs to the glutamine synthetase family. (439 aa) |
| | proC | Pyrroline-5-carboxylate reductase protein ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa) |
| | adhA | Alcohol dehydrogenase AdhA; Region:COG1064G. (341 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit HisZ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (380 aa) |
| | hisG | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (231 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Region:COG0196H; Belongs to the ribF family. (327 aa) |
| | APG90179.1 | Gluconolactonase; Region:COG3386G. (295 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (319 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (645 aa) |
| | APG90263.1 | Acetyltransferase; Region:COG1246E. (170 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase PdxH; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (206 aa) |
| | fabI-2 | Enoyl-(acyl carrier protein) reductase; Region:COG0623I. (272 aa) |
| | aroC | Chorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | ribB | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (366 aa) |
| | thrB | Homoserine kinase ThrB; Region:COG2334T; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | thrC | Threonine synthase ThrC; Region:COG0498E. (468 aa) |
| | APG90317.1 | Export cytoplasm protein SecA ATPase RNA helicase; Region:COG1917R. (98 aa) |
| | cysH | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. (251 aa) |
| | APG90332.1 | Quinone oxidoreductase; Region:COG0604CR. (335 aa) |
| | dkgB | 2,5-diketo-D-gluconic acid reductase B; Region:COG0656Q. (276 aa) |
| | adhT | Alcohol dehydrogenase AdhT; Region:COG1064G. (346 aa) |
| | ilvE-2 | Branched-chain-amino-acid aminotransferase IlvE; Region:COG0115EH. (293 aa) |
| | APG90371.1 | Homocysteine S-methyltransferase; Region:COG2040E. (322 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Region:COG0079E. (373 aa) |
| | dapA | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (139 aa) |
| | rkpK | UDP-glucose 6-dehydrogenase RkpK; Region:COG1004M. (437 aa) |
| | APG90495.1 | AIPM/hcit synthase family transferase; Region:COG0119E; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase FabD; Region:COG0331I. (314 aa) |
| | acpP | Acyl carrier protein AcpP; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | fabF | 3-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (423 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (342 aa) |
| | glyA | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (364 aa) |
| | ribE | Riboflavin synthase subunit alpha; Region:COG0307H. (206 aa) |
| | APG90593.1 | Xanthine dehydrogenase YagR molybdenum-binding subunit YagR; Region:COG1529C. (738 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa) |
| | plsX | Phosphate acyltransferase PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (347 aa) |
| | fabH | 3-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (323 aa) |
| | fabF-2 | 3-oxoacyl-ACP synthase; Region:COG0304IQ; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (392 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa) |
| | APG90668.1 | O-acetylhomoserine aminocarboxypropyltransferase; Region:COG2873E. (427 aa) |
| | APG90670.1 | Hypothetical protein. (398 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (157 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | sdaA | L-serine dehydratase SdaA; Region:COG1760E; Belongs to the iron-sulfur dependent L-serine dehydratase family. (466 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (150 aa) |
| | APG90862.1 | IAA acetyltransferase; Region:COG0456J. (157 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Region:COG2877M; Belongs to the KdsA family. (279 aa) |
| | lipA | Lipoyl synthase LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa) |
| | APG90885.1 | Oligoketide cyclase/lipid transport protein; Region:COG2867J. (149 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa) |
| | hyuE | Hydantoin racemase HyuE; Region:COG4126E. (249 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (179 aa) |
| | APG91676.1 | Phosphoserine phosphatase; Region:COG0560E. (270 aa) |
| | ilvH | Acetolactate synthase small subunit IlvH; Region:COG0440E. (190 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (250 aa) |
| | ilvC | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | APG91611.1 | Phosphoglycolate phosphatase; Region:COG0433L. (570 aa) |
| | fabI-3 | Enoyl-(acyl carrier protein) reductase; Region:COG0623I. (261 aa) |
| | adhA-2 | Alcohol dehydrogenase AdhA; Region:COG1064G. (344 aa) |
| | APG91537.1 | Hypothetical protein. (99 aa) |
| | APG91523.1 | Pyrimidine reductase protein; Region:COG0262H. (219 aa) |
| | APG91510.1 | Electron transfer protein; Region:COG2871C. (690 aa) |
| | metH-2 | Methionine synthase MetH; Region:COG1410E. (320 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (484 aa) |
| | cobP | Bifunctional adenosylcobalamin biosynthesis protein CobP; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (175 aa) |
| | cobW | Protein CobW; Region:COG0523R. (354 aa) |
| | cobN | Aerobic cobaltochelatase subunit CobN; Region:COG1429H. (1284 aa) |
| | cobO | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (214 aa) |
| | cobE | CobE protein CobE. (152 aa) |
| | cobB | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (431 aa) |
| | cobC | Threonine-phosphate decarboxylase CobC; Region:COG0079E. (335 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (326 aa) |
| | acpX | Acyl carrier protein AcpXL; Region:COG0236IQ. (92 aa) |
| | APG91466.1 | (3R)-hydroxymyristoyl-ACP dehydratase; Region:COG0764I. (158 aa) |
| | fabF-4 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Region:COG0304IQ; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (404 aa) |
| | fabF-3 | 3-oxoacyl-ACP synthase; Region:COG0304IQ; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (427 aa) |
| | cobV | Cobalamin synthase CobV; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (262 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase CobT; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (338 aa) |
| | APG91386.1 | Hypothetical protein; Region:COG5425S. (84 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (227 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase AroH; Region:COG3200E. (459 aa) |
| | bluB | Nitroreductase, BluB-like protein; Region:COG0778C. (253 aa) |
| | sul | Dihydropteroate synthase Sul; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (290 aa) |
| | folB | Dihydroneopterin aldolase FolB; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Region:COG0801H. (180 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Region:COG0152F; Belongs to the SAICAR synthetase family. (254 aa) |
| | tgt | Queuine tRNA-ribosyltransferase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to fo [...] (376 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase QueA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (361 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Region:COG0458EF; Belongs to the CarB family. (1186 aa) |
| | APG91228.1 | Acetyltransferase; Region:COG0456J. (142 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Region:COG0111HR; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (336 aa) |
| | APG91116.1 | Hypothetical protein. (66 aa) |
| | menG | 2-heptaprenyl-1,4-naphthoquinone methyltransferase MenG; Region:COG2226H. (274 aa) |
| | cysK-2 | Cysteine synthase A; Region:COG0031E. (346 aa) |
| | gpt | Xanthine phosphoribosyltransferase Gpt; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa) |
| | glnA | Glutamine synthetase; Region:COG0174E. (469 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | trpC | Indole-3-glycerol phosphate synthase TrpC; Region:COG0134E; Belongs to the TrpC family. (271 aa) |
| | APG91014.1 | 2-octaprenyl-6-methoxyphenyl hydroxylase; Region:COG0654HC. (403 aa) |
| | thrA | Homoserine dehydrogenase; Region:COG0460E. (440 aa) |
| | serS | serine--tRNA ligase SerS; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa) |
| | fabZ | (3R)-hydroxymyristoyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (154 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase UppS; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (247 aa) |
| | cysE | Serine acetyltransferase CysE; Region:COG1045E. (275 aa) |
| | sir | Sulfite reductase [ferredoxin] 2; Region:COG0155P. (557 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (485 aa) |
| | ectC | L-ectoine synthase EctC; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (128 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase TrpF; Region:COG0135E; Belongs to the TrpF family. (224 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (304 aa) |
| | folC | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase FolC; Region:COG0285H; Belongs to the folylpolyglutamate synthase family. (447 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase HisE; Region:COG0140E. (107 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Region:COG0106E. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase HisB; Region:COG0131E. (202 aa) |
| | punA | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (265 aa) |
| | pheA | Prephenate dehydratase; Region:COG0077E. (284 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase IlvE; Region:COG0115EH. (363 aa) |
| | APG89522.1 | CysZ-like protein; Region:COG2981E. (247 aa) |
| | APG89531.1 | Glyoxalase/bleomycin resistance protein/dioxygenase; Region:COG0346Q. (141 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (272 aa) |
| | mgsA | Methylglyoxal synthase MgsA; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (126 aa) |
| | ghrA | Glyoxylate/hydroxypyruvate reductase A; Region:COG0111HR. (319 aa) |
| | APG89587.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Region:COG0111HR. (343 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (448 aa) |
| | fabA | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (171 aa) |
| | fabB | 3-oxoacyl-ACP synthase; Region:COG0304IQ; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa) |
| | fabI | Enoyl-(acyl carrier protein) reductase; Region:COG0623I. (268 aa) |
| | queG | Electron transport protein YjeS; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (391 aa) |
| | APG89656.1 | NADH-ubiquinone oxidoreductase; Region:COG0702R. (326 aa) |
| | cysK | Cysteine synthase A. (416 aa) |
| | ubiB | Ubiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. (524 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (270 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (397 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Region:COG2171E; Belongs to the transferase hexapeptide repeat family. (285 aa) |
| | argB | Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | putA | Bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1235 aa) |
| | pgi | Glucose-6-phosphate isomerase; Region:COG0166G; Belongs to the GPI family. (541 aa) |
| | argD | Acetylornithine aminotransferase ArgD; Region:COG4992E; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (419 aa) |
| | argF | Ornithine carbamoyltransferase ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (305 aa) |
| | APG89878.1 | Isochorismate pyruvate-lyase; Region:COG1605E. (101 aa) |
| | bioF | 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase; Region:COG0156H. (471 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | APG89945.1 | PhnB protein; Region:COG2764R. (148 aa) |
| | pdxY | Pyridoxamine kinase PdxY; Region:COG2240H; Belongs to the pyridoxine kinase family. (293 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa) |
| | APG92925.1 | Hypothetical protein; Region:COG0329EM. (390 aa) |
| | APG92924.1 | Omega-amino acid--pyruvate aminotransferase; Region:COG0161H; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | pyc | Pyruvate carboxylase Pyc; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1152 aa) |
| | hisC-3 | Histidinol-phosphate aminotransferase; Region:COG0079E; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | APG92881.1 | Thiamine pyrophosphokinase; Region:COG1564H. (216 aa) |
| | dapF | Diaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (305 aa) |
| | phhB | Pterin-4-alpha-carbinolamine dehydratase; Region:COG2154H. (105 aa) |
| | argG | Argininosuccinate synthase ArgG; Region:COG0137E; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (461 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | APG92824.1 | 2-octaprenyl-6-methoxyphenyl hydroxylase; Region:COG0654HC. (404 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | metA | Homoserine O-succinyltransferase MetA; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (427 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (392 aa) |
| | hemD | uroporphyrinogen-III synthase protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (234 aa) |
| | rocD | Ornithine aminotransferase RocD; Region:COG4992E; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (401 aa) |
| | APG92698.1 | Hypothetical protein; Region:COG2764R. (159 aa) |
| | cutL | Carbon monoxide dehydrogenase; Region:COG1529C. (781 aa) |
| | hemA | 5-aminolevulinate synthase; Region:COG0156H. (404 aa) |
| | metH-3 | Methionine synthase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1256 aa) |
| | cobF | precorrin-6A synthase; Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. (256 aa) |
| | cobG | precorrin-3B synthase CobG; Region:COG0155P. (439 aa) |
| | cobH | precorrin-8X methylmutase CobH; Region:COG2082H. (210 aa) |
| | cobI | Precorrin-2 C(20)-methyltransferase CobI; Region:COG2243H; Belongs to the precorrin methyltransferase family. (246 aa) |
| | cobJ | precorrin-3B C(17)-methyltransferase CobJ; Region:COG1010H. (254 aa) |
| | cobK | precorrin-6A reductase CobK; Region:COG2099H. (266 aa) |
| | cobL | precorrin-6Y C(5,15)-methyltransferase; Region:COG2241H. (413 aa) |
| | cobM | Precorrin-4 C(11)-methyltransferase CobM; Region:COG2875H; Belongs to the precorrin methyltransferase family. (252 aa) |
| | APG92558.1 | Cobalamin synthesis protein/P47K family protein; Region:COG0523R. (368 aa) |
| | APG92557.1 | Creatinine amidohydrolase; Region:COG1402HQ. (263 aa) |
| | ilvD-3 | Dihydroxy-acid dehydratase IlvD; Region:COG0129EG; Belongs to the IlvD/Edd family. (612 aa) |
| | gltB-2 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. (1574 aa) |
| | gltB | Glutamate synthase [NADPH] small subunit; Region:COG0493ER. (485 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase ThiE; Region:COG0352H. (217 aa) |
| | serC | Phosphoserine aminotransferase SerC; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (392 aa) |
| | serA-2 | D-3-phosphoglycerate dehydrogenase; Region:COG0111HR; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa) |
| | APG92353.1 | Inositol-1-phosphate synthase; Region:COG1260I. (367 aa) |
| | APG92341.1 | Membrane-bound dehydrogenase oxidoreductase protein; Region:COG2133G. (329 aa) |
| | adhC | NADP-dependent alcohol dehydrogenase C 2; Region:COG1064G. (348 aa) |
| | APG92320.1 | GTP-binding protein YjiA; Region:COG0523R. (379 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | aroK | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (195 aa) |
