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| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa) |
| | APG89361.1 | Aldo/keto reductase; Region:COG0667R. (339 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase TrpF; Region:COG0135E; Belongs to the TrpF family. (224 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (304 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase HisE; Region:COG0140E. (107 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Region:COG0106E. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase HisB; Region:COG0131E. (202 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa) |
| | adhI | Alcohol dehydrogenase class-3; Region:COG1062R; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (359 aa) |
| | punA | Purine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (265 aa) |
| | pheA | Prephenate dehydratase; Region:COG0077E. (284 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase IlvE; Region:COG0115EH. (363 aa) |
| | gyaR | Glyoxylate reductase GyaR; Region:COG1052CHR; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (272 aa) |
| | glk | Glucokinase; Region:COG0837G; Belongs to the bacterial glucokinase family. (339 aa) |
| | ghrA | Glyoxylate/hydroxypyruvate reductase A; Region:COG0111HR. (319 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (448 aa) |
| | fabI | Enoyl-(acyl carrier protein) reductase; Region:COG0623I. (268 aa) |
| | APG89626.1 | NAD(P)H dehydrogenase; Region:COG2249R. (196 aa) |
| | tatA | Tyrosine aminotransferase TatA; Region:COG1448E. (389 aa) |
| | APG89660.1 | RNA adenine methylase transferase; Region:COG3963I. (200 aa) |
| | cysK | Cysteine synthase A. (416 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (270 aa) |
| | fadB | enoyl-CoA hydratase FadB; Region:COG1024I; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | metK | S-adenosylmethionine synthase MetK; Region:COG0192H; Belongs to the AdoMet synthase family. (422 aa) |
| | argB | Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | putA | Bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1235 aa) |
| | frk | Fructokinase Frk; Region:COG0524G. (308 aa) |
| | pgi | Glucose-6-phosphate isomerase; Region:COG0166G; Belongs to the GPI family. (541 aa) |
| | APG89824.1 | Phosphatidate cytidylyltransferase; Region:COG4589R; Belongs to the CDS family. (313 aa) |
| | argD | Acetylornithine aminotransferase ArgD; Region:COG4992E; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (419 aa) |
| | argF | Ornithine carbamoyltransferase ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (305 aa) |
| | fadB-2 | 3-hydroxyacyl-CoA dehydrogenase; Region:COG1024I. (737 aa) |
| | fadA | Acyltransferase; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa) |
| | APG89878.1 | Isochorismate pyruvate-lyase; Region:COG1605E. (101 aa) |
| | ilvB | Acetolactate synthase isozyme 1 large subunit IlvB; Region:COG0028EH; Belongs to the TPP enzyme family. (536 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | aglA | Alpha-glucosidase AglA; Region:COG0366G. (551 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (232 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa) |
| | aceA | Isocitrate lyase AceA; Region:COG2224C. (429 aa) |
| | adhI-2 | Alcohol dehydrogenase class-3; Region:COG1062R; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (519 aa) |
| | adhA | Alcohol dehydrogenase AdhA; Region:COG1064G. (341 aa) |
| | glcD | Glycolate oxidase subunit GlcD; Region:COG0277C. (479 aa) |
| | glcE | Glycolate oxidase subunit GlcE; Region:COG0277C. (403 aa) |
| | glcF | Glycolate oxidase iron-sulfur subunit GlcF; Region:COG0247C. (430 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit HisZ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (380 aa) |
| | hisG | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (231 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Region:COG0196H; Belongs to the ribF family. (327 aa) |
| | APG90166.1 | Inositol monophosphatase family protein; Region:COG0483G. (272 aa) |
| | APG90169.1 | Phosphoglycolate phosphatase; Region:COG0546C. (234 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (303 aa) |
| | ispB | Octaprenyl-diphosphate synthase IspB; Region:COG0142H; Belongs to the FPP/GGPP synthase family. (338 aa) |
| | purD | Phosphoribosylamine--glycine ligase PurD; Region:COG0151F; Belongs to the GARS family. (423 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (319 aa) |
| | mmgC-2 | acyl-CoA dehydrogenase MmgC; Region:COG1960I. (593 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (645 aa) |
| | vraB | acetyl-CoA C-acetyltransferase VraB; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa) |
| | fabI-2 | Enoyl-(acyl carrier protein) reductase; Region:COG0623I. (272 aa) |
| | aroC | Chorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | ribB | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (366 aa) |
| | ctaB | Protoheme IX farnesyltransferase CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (360 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (336 aa) |
| | thrB | Homoserine kinase ThrB; Region:COG2334T; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | thrC | Threonine synthase ThrC; Region:COG0498E. (468 aa) |
| | ppdK | Pyruvate, phosphate dikinase; Region:COG0574G; Belongs to the PEP-utilizing enzyme family. (896 aa) |
| | cysN | Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (498 aa) |
| | cysD | Sulfate adenylyltransferase subunit 2; Region:COG0175EH. (317 aa) |
| | ilvE-2 | Branched-chain-amino-acid aminotransferase IlvE; Region:COG0115EH. (293 aa) |
| | gdh | Quinoprotein glucose dehydrogenase Gdh; Region:COG4993G. (778 aa) |
| | APG90371.1 | Homocysteine S-methyltransferase; Region:COG2040E. (322 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Region:COG0079E. (373 aa) |
| | dapA | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | APG90495.1 | AIPM/hcit synthase family transferase; Region:COG0119E; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (232 aa) |
| | pssA | CDP-diacylglycerol--serine O-phosphatidyltransferase; Region:COG1183I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (287 aa) |
| | purF | Amidophosphoribosyltransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (497 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase FabD; Region:COG0331I. (314 aa) |
| | nodG | Nodulation protein G; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa) |
| | acpP | Acyl carrier protein AcpP; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | ndk | Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (221 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase PurM; Region:COG0150F. (356 aa) |
| | glyA | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (364 aa) |
| | ribE | Riboflavin synthase subunit alpha; Region:COG0307H. (206 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa) |
| | plsX | Phosphate acyltransferase PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (347 aa) |
| | hemN | Oxygen-independent coproporphyrinogen-III oxidase HemN; Region:COG0635H; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (450 aa) |
| | ctaA | Heme A synthase HAS, Cytochrome aa3-controlling protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (367 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa) |
| | plsY | Glycerol-3-phosphate acyltransferase PlsY; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (203 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (157 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | adk | Adenylate kinase Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | APG90812.1 | Hydrolase; Region:COG0546C. (221 aa) |
| | adhI-3 | Alcohol dehydrogenase class-3; Region:COG1062R; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa) |
| | sdaA | L-serine dehydratase SdaA; Region:COG1760E; Belongs to the iron-sulfur dependent L-serine dehydratase family. (466 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (150 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (348 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (455 aa) |
| | pdhC | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (447 aa) |
| | lpdA | Dihydrolipoyl dehydrogenase LpdA; Region:COG1249C. (481 aa) |
| | ispD | Bifunctional enzyme IspD/IspF; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (418 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (485 aa) |
| | metC | Cystathionine beta-lyase MetC; Region:COG0626E. (395 aa) |
| | cysE | Serine acetyltransferase CysE; Region:COG1045E. (275 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase UppS; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (247 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Region:COG0575I; Belongs to the CDS family. (277 aa) |
| | gltA | Citrate synthase GltA; Region:COG0372C; Belongs to the citrate synthase family. (429 aa) |
| | surE | Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa) |
| | APG90976.1 | Phytoene synthase; Region:COG1562I. (279 aa) |
| | thrA | Homoserine dehydrogenase; Region:COG0460E. (440 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (310 aa) |
| | APG91014.1 | 2-octaprenyl-6-methoxyphenyl hydroxylase; Region:COG0654HC. (403 aa) |
| | pcs | Phosphatidylcholine synthase Pcs; Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (241 aa) |
| | gpmB-2 | Phosphoglycerate kinase; Region:COG0406G. (212 aa) |
| | trpC | Indole-3-glycerol phosphate synthase TrpC; Region:COG0134E; Belongs to the TrpC family. (271 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | gpt | Xanthine phosphoribosyltransferase Gpt; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa) |
| | ilvA | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa) |
| | cysK-2 | Cysteine synthase A; Region:COG0031E. (346 aa) |
| | purB | Adenylosuccinate lyase PurB; Region:COG0015F; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | cbbE | Ribulose-phosphate 3-epimerase CbbE; Region:COG0036G; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa) |
| | gcvH | Glycine cleavage system H protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (120 aa) |
| | gcvT | Aminomethyltransferase GcvT; Region:COG0404E. (373 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Region:COG0152F; Belongs to the SAICAR synthetase family. (254 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (80 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (742 aa) |
| | icd | Isocitrate dehydrogenase; Region:COG0538C; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa) |
| | dapA-3 | Dihydrodipicolinate synthase DapA; Region:COG0329EM; Belongs to the DapA family. (294 aa) |
| | hemF | coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (303 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase AroH; Region:COG3200E. (459 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (227 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (473 aa) |
| | dgkA | Diacylglycerol kinase DgkA; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (136 aa) |
| | APG91449.1 | 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa) |
| | cobA | uroporphyrinogen-III C-methyltransferase CobA; Region:COG0007H; Belongs to the precorrin methyltransferase family. (278 aa) |
| | metH | Methionine synthase MetH; Region:COG0646E. (338 aa) |
| | metH-2 | Methionine synthase MetH; Region:COG1410E. (320 aa) |
| | adhA-2 | Alcohol dehydrogenase AdhA; Region:COG1064G. (344 aa) |
| | fabI-3 | Enoyl-(acyl carrier protein) reductase; Region:COG0623I. (261 aa) |
| | APG91588.1 | Phenazine antibiotic biosynthesis-like protein; Region:COG0384R. (305 aa) |
| | ilvC | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | qorB | Quinone oxidoreductase 2; Region:COG0702R. (295 aa) |
| | ilvH | Acetolactate synthase small subunit IlvH; Region:COG0440E. (190 aa) |
| | ilvI | Acetolactate synthase isozyme 3 large subunit IlvI; Region:COG0028EH. (592 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (302 aa) |
| | APG91676.1 | Phosphoserine phosphatase; Region:COG0560E. (270 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa) |
| | panC | Pantothenate synthetase PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (291 aa) |
| | pfp | Pyrophosphate--fructose 6-phosphate 1-phosphotransferase Pfp; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (404 aa) |
| | ilvB-2 | Acetolactate synthase large subunit IlvB; Region:COG0028EH; Belongs to the TPP enzyme family. (548 aa) |
| | ribH-2 | 6,7-dimethyl-8-ribityllumazine synthase 2; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (157 aa) |
| | APG91799.1 | acyl-CoA dehydrogenase YngJ; Region:COG1960I. (386 aa) |
| | aatA | Aspartate aminotransferase A; Region:COG0436E. (400 aa) |
| | proC-2 | Pyrroline-5-carboxylate reductase ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | acoD | Acetaldehyde dehydrogenase 2; Region:COG1012C; Belongs to the aldehyde dehydrogenase family. (536 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (587 aa) |
| | trpE | Anthranilate synthase; Region:COG0147EH. (729 aa) |
| | aglA-2 | Alpha-glucosidase AglA; Region:COG0366G. (550 aa) |
| | idhA | Inositol 2-dehydrogenase IdhA; Region:COG0673R. (328 aa) |
| | rmlC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (177 aa) |
| | ald-3 | Aldehyde dehydrogenase; Region:COG1012C; Belongs to the aldehyde dehydrogenase family. (477 aa) |
| | APG92203.1 | Aspartate aminotransferase; Region:COG1168ER. (412 aa) |
| | lysC | Aspartokinase LysC; Region:COG0527E; Belongs to the aspartokinase family. (424 aa) |
| | ubiG | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (248 aa) |
| | argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa) |
| | APG92268.1 | acetyl-CoA synthetase; Region:COG0365I. (548 aa) |
| | argH | Argininosuccinate lyase ArgH; Region:COG0165E. (467 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa) |
| | hpt | Hypoxanthine-guanine phosphoribosyltransferase Hpt; Region:COG0634F; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | plsC-3 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Region:COG0204I. (260 aa) |
| | tyrC | Cyclohexadienyl dehydrogenase; Region:COG0287E. (308 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase; Region:COG0079E; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa) |
| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (376 aa) |
| | aroK | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (195 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | adhC | NADP-dependent alcohol dehydrogenase C 2; Region:COG1064G. (348 aa) |
| | APG92349.1 | UDP-glucose 4-epimerase; Region:COG0451M. (368 aa) |
| | APG92353.1 | Inositol-1-phosphate synthase; Region:COG1260I. (367 aa) |
| | dapA-4 | Dihydrodipicolinate synthase DapA; Region:COG0329EM; Belongs to the DapA family. (302 aa) |
| | serA-2 | D-3-phosphoglycerate dehydrogenase; Region:COG0111HR; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa) |
| | serC | Phosphoserine aminotransferase SerC; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (392 aa) |
| | cbbT | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase; Region:COG0057G; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | pgk | Phosphoglycerate kinase; Region:COG0126G; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | fbaB | Fructose-bisphosphate aldolase; Region:COG3588G; Belongs to the class I fructose-bisphosphate aldolase family. (341 aa) |
| | APG92448.1 | Phenazine antibiotic biosynthesis-like protein; Region:COG0384R. (305 aa) |
| | suhB | Inositol-1-monophosphatase SuhB; Region:COG0483G; Belongs to the inositol monophosphatase superfamily. (266 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa) |
| | purK | N5-carboxyaminoimidazole ribonucleotide synthase PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (349 aa) |
| | pyk | Pyruvate kinase Pyk; Region:COG0469G; Belongs to the pyruvate kinase family. (479 aa) |
| | hss | Homospermidine synthase Hss; Region:COG5310Q. (483 aa) |
| | APG92489.1 | 5'-nucleotidase; Region:COG0737FV; Belongs to the 5'-nucleotidase family. (621 aa) |
| | hemH | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (349 aa) |
| | arcA | Arginine deiminase; Region:COG2235E. (420 aa) |
| | exoN | UTP--glucose-1-phosphate uridylyltransferase ExoN; Region:COG1210M. (295 aa) |
| | gltB | Glutamate synthase [NADPH] small subunit; Region:COG0493ER. (485 aa) |
| | gltB-2 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. (1574 aa) |
| | ltaE | Low specificity L-threonine aldolase LtaE; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (351 aa) |
| | ilvD-3 | Dihydroxy-acid dehydratase IlvD; Region:COG0129EG; Belongs to the IlvD/Edd family. (612 aa) |
| | glgP | Glycogen phosphorylase GlgP; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (821 aa) |
| | glgB | 1,4-alpha-glucan branching enzyme GlgB; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (736 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (420 aa) |
| | glgA | Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (480 aa) |
| | pgm | Phosphoglucomutase Pgm; Region:COG0033G. (542 aa) |
| | ldc | Lysine/ornithine decarboxylase Ldc; Region:COG0019E; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (377 aa) |
| | abg | Beta-glucosidase Abg; Region:COG2723G. (457 aa) |
| | gltX | glutamate--tRNA ligase GltX; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa) |
| | bkdA | 2-oxoisovalerate dehydrogenase subunit alpha; Region:COG1071C. (410 aa) |
| | bkdA-2 | 2-oxoisovalerate dehydrogenase subunit beta; Region:COG0022C. (334 aa) |
| | bkdB | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Region:COG0508C. (424 aa) |
| | lpdA-2 | Dihydrolipoamide dehydrogenase; Region:COG1249C. (464 aa) |
| | atoB | acetyl-CoA acetyltransferase AtoB; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | metH-3 | Methionine synthase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1256 aa) |
| | mak | Fructokinase Mak; Region:COG1940KG. (298 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (390 aa) |
| | hemA | 5-aminolevulinate synthase; Region:COG0156H. (404 aa) |
| | arcB | Arginase ArcB; Region:COG0010E; Belongs to the arginase family. (307 aa) |
| | rocD | Ornithine aminotransferase RocD; Region:COG4992E; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (401 aa) |
| | fabG-2 | 3-oxoacyl-ACP reductase; Region:COG1028IQR. (256 aa) |
| | glpD | Aerobic glycerol-3-phosphate dehydrogenase GlpD; Region:COG0578C; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (505 aa) |
| | tal | Transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | lpdA-3 | Dihydrolipoamide dehydrogenase; Region:COG1249C. (468 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (413 aa) |
| | sucA | 2-oxoglutarate dehydrogenase E1 componentSucA; Region:COG0567C. (998 aa) |
| | sucD | succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | sucC | succinyl-CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa) |
| | mdh-3 | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (339 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur subunit SdhB; Region:COG0479C; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit SdhA; Region:COG1053C; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (613 aa) |
| | APG92758.1 | Succinate dehydrogenase hydrophobic membrane anchor protein; Region:COG2142C. (126 aa) |
| | APG92759.1 | Succinate dehydrogenase membrane anchor subunit; Region:COG2009C. (130 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Region:COG0240C; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (333 aa) |
| | hemC | Porphobilinogen deaminase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa) |
| | hemD | uroporphyrinogen-III synthase protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (234 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (392 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (427 aa) |
| | galM | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (348 aa) |
| | metA | Homoserine O-succinyltransferase MetA; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | APG92824.1 | 2-octaprenyl-6-methoxyphenyl hydroxylase; Region:COG0654HC. (404 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | argG | Argininosuccinate synthase ArgG; Region:COG0137E; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (461 aa) |
| | acnA | Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa) |
| | dapF | Diaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (305 aa) |
| | APG92875.1 | Chorismate mutase; Region:COG1605E. (111 aa) |
| | phbA | acetyl-CoA acetyltransferase PhbA; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | ispA | Geranyltranstransferase; Region:COG0142H; Belongs to the FPP/GGPP synthase family. (339 aa) |
| | hisC-3 | Histidinol-phosphate aminotransferase; Region:COG0079E; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (417 aa) |
| | gabD-2 | Succinate-semialdehyde dehydrogenase [NADP+]; Region:COG1012C. (510 aa) |
| | aatB | Aspartate aminotransferase B; Region:COG0436E. (410 aa) |
| | ttuD | Hydroxypyruvate reductase TtuD; Region:COG2379G. (423 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | purH | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Region:COG0138F. (536 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa) |
| | APG92976.1 | Protoporphyrinogen IX oxidase, HemJ; Region:COG1981S. (179 aa) |
| | hemE | Uroporphyrinogen decarboxylase HemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (344 aa) |
