32 items (Campylobacter coli) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

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Your Input:
	folD	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
	ansZ	L-asparaginase 2 precursor; Belongs to the asparaginase 1 family. (331 aa)
	guaD	Aminodeoxyfutalosine deaminase. (409 aa)
	ribD	Riboflavin biosynthesis protein RibD. (326 aa)
	hisE	Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (207 aa)
	hisH2	Imidazole glycerol phosphate synthase subunit HisH 2; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa)
	pxpA	LamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (256 aa)
	ALU98797.1	Hypothetical protein. (243 aa)
	ALU98862.1	Hypothetical protein. (113 aa)
	kynB	Kynurenine formamidase. (224 aa)
	hisH1	Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa)
	dcd	Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (186 aa)
	yfiH	Laccase domain protein YfiH. (226 aa)
	pgdA	Peptidoglycan deacetylase. (293 aa)
	pyrC_1	Dihydroorotase. (393 aa)
	dapE	Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (366 aa)
	ribA	GTP cyclohydrolase-2. (186 aa)
	aguA	Agmatine deiminase; Belongs to the agmatine deiminase family. (325 aa)
	purH	Bifunctional purine biosynthesis protein PurH. (510 aa)
	lpxC	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (294 aa)
	folE	GTP cyclohydrolase 1. (200 aa)
	def	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (175 aa)
	pyrC_2	Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (334 aa)
	nadE	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (248 aa)
	purU	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (274 aa)
	hiuH	5-hydroxyisourate hydrolase precursor; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (137 aa)
	amiA	N-acetylmuramoyl-L-alanine amidase AmiA precursor. (656 aa)
	purQ	Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (214 aa)
	tenA	Thiaminase-2; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (221 aa)
	hcpC_1	Putative beta-lactamase HcpC precursor; Hydrolyzes 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives. (234 aa)
	hcpC_2	Putative beta-lactamase HcpC precursor. (203 aa)
	bla	Beta-lactamase OXA-10 precursor. (257 aa)

Your Current Organism:

Campylobacter coli

NCBI taxonomy Id: 195
Other names: ATCC 33559, C. coli, CCUG 11283, CCUG 14540, CCUG:33450 [[Campylobacter hyoilei]], CIP 70.80, CIP 7080, Campylobacter hyoilei, Campylobacter sp. OH-18-18281-4B, Campylobacter sp. OH-18-7816, DSM 4689, JCM 2529, LMG 6440, LMG 9860, LMG:6440, LMG:9860, NCTC 11366, Vibrio coli, strain RMIT 32A [[Campylobacter hyoilei]]

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ansZ	pgdA	ATE51_00056	ATE51_01194	L-asparaginase 2 precursor; Belongs to the asparaginase 1 family.	Peptidoglycan deacetylase.	0.714
dapE	folE	ATE51_01522	ATE51_04166	Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.	GTP cyclohydrolase 1.	0.463
dapE	ribD	ATE51_01522	ATE51_00284	Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.	Riboflavin biosynthesis protein RibD.	0.405
def	folD	ATE51_04160	ATE51_01932	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.419
def	folE	ATE51_04160	ATE51_04166	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	GTP cyclohydrolase 1.	0.613
def	hisE	ATE51_04160	ATE51_00340	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	0.453
folD	def	ATE51_01932	ATE51_04160	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	0.419
folD	folE	ATE51_01932	ATE51_04166	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	GTP cyclohydrolase 1.	0.476
folD	purH	ATE51_01932	ATE51_01860	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Bifunctional purine biosynthesis protein PurH.	0.973
folD	purQ	ATE51_01932	ATE51_03174	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]	0.480
folD	purU	ATE51_01932	ATE51_02060	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.940
folD	ribD	ATE51_01932	ATE51_00284	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Riboflavin biosynthesis protein RibD.	0.447
folE	dapE	ATE51_04166	ATE51_01522	GTP cyclohydrolase 1.	Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.	0.463
folE	def	ATE51_04166	ATE51_04160	GTP cyclohydrolase 1.	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	0.613
folE	folD	ATE51_04166	ATE51_01932	GTP cyclohydrolase 1.	Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.476
folE	hisE	ATE51_04166	ATE51_00340	GTP cyclohydrolase 1.	Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	0.495
folE	ribA	ATE51_04166	ATE51_01636	GTP cyclohydrolase 1.	GTP cyclohydrolase-2.	0.966
folE	ribD	ATE51_04166	ATE51_00284	GTP cyclohydrolase 1.	Riboflavin biosynthesis protein RibD.	0.551
guaD	hiuH	ATE51_00140	ATE51_02192	Aminodeoxyfutalosine deaminase.	5-hydroxyisourate hydrolase precursor; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.	0.463
guaD	pyrC_2	ATE51_00140	ATE51_03838	Aminodeoxyfutalosine deaminase.	Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.	0.404

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