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| | pckA | Phosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (524 aa) |
| | mdeA | Methionine gamma-lyase. (423 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa) |
| | leuD1 | 3-isopropylmalate dehydratase small subunit 1; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | mqnD | 1,4-dihydroxy-6-naphtoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (287 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (414 aa) |
| | nnr | Bifunctional NAD(P)H-hydrate repair enzyme Nnr; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (456 aa) |
| | moaA_2 | Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (320 aa) |
| | queE | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (247 aa) |
| | cynT | Carbonic anhydrase 1; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (211 aa) |
| | moaC | Cyclic pyranopterin monophosphate synthase accessory protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (157 aa) |
| | fabZ | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa) |
| | prpB | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (291 aa) |
| | prpD | 2-methylcitrate dehydratase. (484 aa) |
| | panD | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (402 aa) |
| | pheA | P-protein. (360 aa) |
| | trpE | Anthranilate synthase component 1. (413 aa) |
| | trpGD | Bifunctional protein TrpGD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (530 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (392 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (249 aa) |
| | ALV00259.1 | Dihydroneopterin aldolase. (105 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (279 aa) |
| | citE | Citrate lyase subunit beta-like protein; Belongs to the HpcH/HpaI aldolase family. (277 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (430 aa) |
| | dapA_2 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family. (302 aa) |
| | uxaA_2 | Altronate dehydratase. (87 aa) |
| | uxaA_1 | Altronate dehydratase. (388 aa) |
| | trpC_1 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (258 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (303 aa) |
| | yceG | Putative aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (300 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Belongs to the UbiD family. (600 aa) |
| | rluD_3 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (321 aa) |
| | mltD | Membrane-bound lytic murein transglycosylase D precursor. (377 aa) |
| | rlpA | RlpA-like protein precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (279 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa) |
| | rluD_2 | Ribosomal large subunit pseudouridine synthase D. (250 aa) |
| | speA | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (611 aa) |
| | pad1 | Putative aromatic acid decarboxylase. (187 aa) |
| | dapA_1 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | thrC | Threonine synthase. (470 aa) |
| | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (384 aa) |
| | tdcB | L-threonine dehydratase catabolic TdcB. (403 aa) |
| | acnB | Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (848 aa) |
| | slt | Soluble lytic murein transglycosylase precursor. (542 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (266 aa) |
| | pabB | Aminodeoxychorismate synthase component 1. (592 aa) |
| | trpG | Anthranilate synthase component 2. (192 aa) |
| | argH1 | Argininosuccinate lyase 1. (461 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (327 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (351 aa) |
| | thiH | 2-iminoacetate synthase. (381 aa) |
| | ALU99256.1 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (209 aa) |
| | nth_2 | Endonuclease III. (227 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (272 aa) |
| | pglF | UDP-N-acetyl-alpha-D-glucosamine C6 dehydratase. (590 aa) |
| | rfbB | dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (343 aa) |
| | luxS | S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (164 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (340 aa) |
| | fba | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (354 aa) |
| | nth_1 | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (208 aa) |
| | ribBA | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. Belongs to the DHBP synthase family. (339 aa) |
| | mqnA | Hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (223 aa) |
| | hisF_2 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (248 aa) |
| | hisH1 | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | rmd | GDP-6-deoxy-D-mannose reductase. (330 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | metC | Cystathionine beta-lyase. (387 aa) |
| | pcaB | 3-carboxy-cis,cis-muconate cycloisomerase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa) |
| | truD | tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (372 aa) |
| | nspC | Carboxynorspermidine/carboxyspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. (382 aa) |
| | ALU98783.1 | Hypothetical protein; Belongs to the D-glutamate cyclase family. (254 aa) |
| | hisB | Histidine biosynthesis bifunctional protein HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. (353 aa) |
| | hisH2 | Imidazole glycerol phosphate synthase subunit HisH 2; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | hisF_1 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | ispDF | Bifunctional enzyme IspD/IspF; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (371 aa) |
| | tdcG | L-serine dehydratase TdcG; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | aspA | Aspartate ammonia-lyase. (468 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (162 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (442 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (558 aa) |
