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fus fus CPE1295 CPE1295 tig tig rpsO rpsO rrf rrf CPE1698 CPE1698 CPE1699 CPE1699 rpsB rpsB rplS rplS rpsP rpsP rpmF rpmF rpmB rpmB efp efp ctc ctc rplT rplT rpmL rpmL infC infC CPE2023 CPE2023 CPE2037 CPE2037 lepA lepA rpsT rpsT CPE2128 CPE2128 CPE2130 CPE2130 rpsA rpsA CPE2172 CPE2172 rpmE rpmE rpsD rpsD rpsI rpsI rplM rplM rplQ rplQ rpsD-2 rpsD-2 rpsK rpsK rpsM rpsM rpmJ rpmJ infA infA CPE2382 CPE2382 rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ tufA tufA fus-2 fus-2 rpsG rpsG rpsL rpsL rplL rplL rplJ rplJ rplA rplA rplK rplK rpmG rpmG tufA-2 tufA-2 CPE2456 CPE2456 rplI rplI rpsR rpsR rpsF rpsF rpmH rpmH
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fusElongation factor G; 696 aa, similar to gpu:AP001507_131 translation elongation factor G (EF-G) from Bacillus halodurans (692 aa); 40.9% identity in 677 aa overlap; CPE0079; EF-G. (696 aa)
CPE1295Probable SSRA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then sw [...] (156 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (428 aa)
rpsO30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (87 aa)
rrfRibosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
CPE1698Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
CPE1699Translation elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (303 aa)
rpsB30S ribosomal protein S2; 233 aa, similar to gpu:AP001515_161 ribosomal protein S2 from Bacillus halodurans (244 aa); 69.1% identity in 233 aa overlap. 1 putative transmembrane region was found by PSORT; CPE1700; Belongs to the universal ribosomal protein uS2 family. (233 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa)
rpsP81 aa, similar to pir:C47154 ribosomal protein S16 (BS17) rpsP from Bacillus subtilis (90 aa); 72.5% identity in 80 aa overlap; BS17; CPE1712; Belongs to the bacterial ribosomal protein bS16 family. (81 aa)
rpmF50S ribosomal protein L32; 60 aa, similar to gpu:AP001516_12 ribosomal protein L32 from Bacillus halodurans (57 aa); 50.9% identity in 57 aa overlap; CPE1722; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
rpmB84 aa, similar to sp:R28A_STRCO 50S RIBOSOMAL PROTEIN L28- from Streptomyces coelicolor A3(2) (63 aa); 58.6% identity in 58 aa overlap; CPE1734; Belongs to the bacterial ribosomal protein bL28 family. (84 aa)
efpTranslation elongation factor EF-P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa)
ctcProbable general stress protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (203 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
rpmL50S ribosomal protein L35; 65 aa, similar to gpu:AP001517_261 ribosomal protein L35 from Bacillus halodurans (66 aa); 62.5% identity in 64 aa overlap; CPE1893; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
infCTranslation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (134 aa)
CPE202358 aa, similar to sp:RS21_MYXXA 30S RIBOSOMAL PROTEIN S21 from Myxococcus xanthus (64 aa); 69.8% identity in 43 aa overlap; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
CPE2037Hypothetical protein; 89 aa, no significant homology; Belongs to the bacterial ribosomal protein bL25 family. (89 aa)
lepAGTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (600 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (87 aa)
CPE2128100 aa, similar to sp:RL27_BACSU 50S RIBOSOMAL PROTEIN L27 (BL30) (BL24) from Bacillus subtilis (134 aa); 78.3% identity in 92 aa overlap; Belongs to the bacterial ribosomal protein bL27 family. (100 aa)
CPE213050S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpsA378 aa, similar to gp:AF045481_1 30S ribosomal protein S1 from Corynebacterium ammoniagenes (489 aa); 36.6% identity in 358 aa overlap; CPE2150. (378 aa)
CPE217230S ribosomal protein S30AE family; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (179 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA. (68 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (197 aa)
rpsI30S ribosomal protein S9; 130 aa, similar to gpu:AP001507_169 ribosomal protein S9 (BS10) from Bacillus halodurans (130 aa); 70% identity in 130 aa overlap; CPE2369; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa)
rplQ113 aa, similar to gp:AB034247_3 ribosomal protein L17 from Clostridium perfringens (82 aa); 100% identity in 82 aa overlap; CPE2375. (113 aa)
rpsD-230S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (131 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
rpmJ37 aa, similar to sp|P20278|RL36_BACSU 50S RIBOSOMAL PROTEIN L36 (RIBOSOMAL PROTEIN II) (RIBOSOMAL PROTEIN B) (BL38); CPE2380; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
CPE2382Hypothetical protein; 102 aa, no significant homology. (102 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpmD57 aa, similar to gpu:AE004326_4 ribosomal protein L30 from Vibrio cholerae (58 aa); 58.6% identity in 58 aa overlap; CPE2387. (57 aa)
rpsE30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (165 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (119 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rplX50S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (104 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa)
rpmC69 aa, similar to sp:RL29_BACST 50S RIBOSOMAL PROTEIN L29 from Bacillus stearothermophilus (66 aa); 64.6% identity in 65 aa overlap; CPE2397. (69 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (222 aa)
rplV50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (111 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (97 aa)
rplD50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (175 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (216 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
tufAElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa)
fus-2Translation elongation factor EF-G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (688 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (126 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (121 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (169 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rpmG49 aa, similar to sp:RL33_THETH 50S RIBOSOMAL PROTEIN L33 from Thermus thermophilus (54 aa); 61.2% identity in 49 aa overlap; CPE2420. (49 aa)
tufA-2Elongation factor Tu; 397 aa, similar to sp:EFTU_BACST ELONGATION FACTOR TU (EF-TU) from Bacillus stearothermophilus (395 aa); 68% identity in 397 aa overlap; CPE2421; EF-Tu. (397 aa)
CPE2456Hypothetical protein; 165 aa, no significant homology Putative N-terminal signal sequence and 1 putative transmembrane region were found by PSORT. (165 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (148 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (80 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa)
rpmH44 aa, similar to pir|C75308 ribosomal protein L34 from Deinococcus radiodurans (strain R1) (47 aa); 55.8% identity in 43 aa overlap; CPE2660; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
Your Current Organism:
Clostridium perfringens 13
NCBI taxonomy Id: 195102
Other names: C. perfringens str. 13, Clostridium perfringens str. 13
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