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CPF_0069 CPF_0069 CPF_0070 CPF_0070 nagE nagE CPF_0076 CPF_0076 CPF_0079 CPF_0079 CPF_0081 CPF_0081 ldh ldh nanE nanE nanA nanA CPF_0179 CPF_0179 CPF_0180 CPF_0180 CPF_0181 CPF_0181 CPF_0182 CPF_0182 galE galE CPF_0292 CPF_0292 CPF_0293 CPF_0293 pfkA pfkA pyk pyk deoB deoB CPF_0421 CPF_0421 CPF_0422 CPF_0422 CPF_0423 CPF_0423 galU galU galE-2 galE-2 galU-2 galU-2 CPF_0510 CPF_0510 treB treB treC treC treR treR fruA fruA fruK fruK CPF_0566 CPF_0566 CPF_0642 CPF_0642 tal tal CPF_0718 CPF_0718 CPF_0722 CPF_0722 CPF_0731 CPF_0731 CPF_0732 CPF_0732 CPF_0733 CPF_0733 scrK scrK CPF_0802 CPF_0802 CPF_1070 CPF_1070 CPF_1087 CPF_1087 CPF_1244 CPF_1244 CPF_1281 CPF_1281 ppcA ppcA pfkA-2 pfkA-2 eno eno gpmI gpmI tpiA tpiA pgk pgk gap gap galK galK galT galT fba fba pfp pfp CPF_1782 CPF_1782 CPF_1783 CPF_1783 scrR scrR CPF_1785 CPF_1785 prs prs pulA pulA CPF_1839 CPF_1839 glgB glgB rpe rpe CPF_2065 CPF_2065 CPF_2127 CPF_2127 CPF_2149 CPF_2149 CPF_2150 CPF_2150 ppdK ppdK deoC deoC CPF_2333 CPF_2333 CPF_2334 CPF_2334 pyk-2 pyk-2 ptsG ptsG nagA nagA rpiB rpiB CPF_2493 CPF_2493 pgi pgi CPF_2609 CPF_2609 glmM glmM CPF_2645 CPF_2645 glgP glgP malQ malQ CPF_2648 CPF_2648 nagB nagB gapN gapN prsA prsA glmU glmU spoVG spoVG purR purR CPF_2902 CPF_2902
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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CPF_0069Transcription antiterminator; Identified by similarity to SP:P15401; match to protein family HMM PF00874; match to protein family HMM PF03123. (282 aa)
CPF_0070Putative PTS system, N-acetylglucosamine-specific IIA component; Identified by match to protein family HMM PF00358; match to protein family HMM TIGR00830. (159 aa)
nagEPTS system, N-acetylglucosamine-specific IIBC component; Identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR01998. (481 aa)
CPF_0076Putative glucokinase; Identified by similarity to SP:P54495; match to protein family HMM PF00480. (315 aa)
CPF_0079Putative transcriptional regulator IolR; Identified by similarity to SP:P46337; match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279. (256 aa)
CPF_0081Putative fructose-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167. (281 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa)
nanEN-acetylmannosamine-6-phosphate epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (221 aa)
nanAN-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (288 aa)
CPF_0179Identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (505 aa)
CPF_0180Conserved hypothetical protein subfamily; Identified by similarity to GB:CAG20668.1; match to protein family HMM PF04074; match to protein family HMM TIGR00022. (150 aa)
CPF_0181ROK family protein; Identified by match to protein family HMM PF00480. (295 aa)
CPF_0182Transcriptional regulator, RpiR family; Identified by match to protein family HMM PF01380; match to protein family HMM PF01418. (279 aa)
galEUDP-glucose 4-epimerase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (328 aa)
CPF_0292Putative transketolase, N-terminal subunit; Identified by similarity to SP:Q58094; match to protein family HMM PF00456. (274 aa)
CPF_0293Putative transketolase, C-terminal subunit; Identified by similarity to SP:Q58092; match to protein family HMM PF02779; match to protein family HMM PF02780. (314 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
pykPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (467 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (396 aa)
CPF_0421Putative oligo-1,6-glucosidase; Identified by similarity to SP:P29094; match to protein family HMM PF00128. (554 aa)
CPF_0422PTS system, IIBC component; Identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR02003. (551 aa)
CPF_0423Identified by match to protein family HMM PF03372. (263 aa)
galUUTP-glucose-1-phosphate uridylyltransferase; Identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099. (306 aa)
galE-2UDP-glucose 4-epimerase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (338 aa)
galU-2UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to SP:Q05852; match to protein family HMM PF00483; match to protein family HMM TIGR01099. (314 aa)
CPF_0510Putative D-lactate dehydrogenase; Identified by similarity to SP:P52643; match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
treBPTS system, trehalose-specific IIBC component; Identified by similarity to SP:P36672; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR01992. (473 aa)
treCAlpha,alpha-phosphotrehalase; Identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403. (555 aa)
treRTrehalose operon repressor; Identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404. (235 aa)
fruAPTS system, fructose-specific, IIABC component; Identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427. (630 aa)
fruK1-phosphofructokinase; Identified by similarity to SP:O31714; match to protein family HMM PF00294; match to protein family HMM TIGR03168; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (306 aa)
CPF_0566Transcriptional regulator, DeoR family; Identified by match to protein family HMM PF00455; match to protein family HMM PF08220. (248 aa)
CPF_0642Transcriptional regulator, DeoR family; Identified by similarity to GB:AAO80924.1; match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279. (259 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa)
CPF_0718Transcriptional regulator, DeoR family; Identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279. (254 aa)
CPF_0722Putative lipoprotein; Identified by match to protein family HMM PF01344; match to protein family HMM TIGR03548. (384 aa)
CPF_0731ROK family protein; Identified by match to protein family HMM PF00480. (372 aa)
CPF_0732L-iditol 2-dehydrogenase; Identified by similarity to SP:Q06004; match to protein family HMM PF00107; match to protein family HMM PF08240. (348 aa)
CPF_0733Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00792. (465 aa)
scrKFructokinase; Identified by similarity to GB:AAC99323.1; match to protein family HMM PF00294. (310 aa)
CPF_0802Glycosyl hydrolase, family 13; Identified by match to protein family HMM PF00128; match to protein family HMM PF02903; Belongs to the glycosyl hydrolase 13 family. (610 aa)
CPF_1070PTS system, N-acetylglucosamine-specific IIBC component; Identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR01998. (483 aa)
CPF_1087Identified by match to protein family HMM PF00128; match to protein family HMM PF02368; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF07523; match to protein family HMM TIGR01167; match to protein family HMM TIGR02104; Belongs to the glycosyl hydrolase 13 family. (2638 aa)
CPF_1244Putative membrane protein. (355 aa)
CPF_1281Pyruvate kinase barrel domain protein; Identified by match to protein family HMM PF00224; Belongs to the pyruvate kinase family. (360 aa)
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (537 aa)
pfkA-2Phosphofructokinase family protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (365 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
pgkPhosphoglycerate kinase; Identified by similarity to SP:P40924; match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (397 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Identified by similarity to SP:Q59309; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (387 aa)
galTGalactose-1-phosphate uridylyltransferase; Identified by match to protein family HMM PF01087; match to protein family HMM PF02744. (498 aa)
fbaFructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (288 aa)
pfpPhosphofructokinase family protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (400 aa)
CPF_1782Fructokinase; Identified by similarity to GB:AAC99323.1; match to protein family HMM PF00294. (315 aa)
CPF_1783Sucrose-6-phosphate dehydrogenase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (487 aa)
scrRSucrose operon repressor; Identified by similarity to SP:P74892; match to protein family HMM PF00532. (315 aa)
CPF_1785PTS system, sucrose-specific IIBC component; Identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR01996. (450 aa)
prsRibose-phosphate pyrophosphokinase; Identified by similarity to SP:P08330; match to protein family HMM PF00156; match to protein family HMM TIGR01251; Belongs to the ribose-phosphate pyrophosphokinase family. (364 aa)
pulAPullulanase, type I; Identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; Belongs to the glycosyl hydrolase 13 family. (655 aa)
CPF_1839Putative pullulanase; Identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; Belongs to the glycosyl hydrolase 13 family. (1064 aa)
glgB1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (659 aa)
rpeRibulose-phosphate 3-epimerase; Identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa)
CPF_2065Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. (176 aa)
CPF_2127Identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (575 aa)
CPF_2149Identified by match to protein family HMM PF01869. (326 aa)
CPF_2150Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. (184 aa)
ppdKPyruvate, phosphate dikinase; Identified by similarity to SP:P22983; match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family. (876 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (224 aa)
CPF_2333Alpha-glucosidase; Identified by similarity to SP:Q9F234; match to protein family HMM PF01055; Belongs to the glycosyl hydrolase 31 family. (746 aa)
CPF_2334ROK family protein; Identified by match to protein family HMM PF00480. (297 aa)
pyk-2Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (474 aa)
ptsGPTS system, glucose-specific IIBC component; Identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR02002. (509 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase; Identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221. (378 aa)
rpiBRibose 5-phosphate isomerase B; Identified by similarity to SP:P37351; match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (149 aa)
CPF_2493PTS system, lactose/cellobiose-specific IIB component; Identified by match to protein family HMM PF02302. (109 aa)
pgiGlucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (450 aa)
CPF_2609Glycosyl hydrolase, family 1; Identified by match to protein family HMM PF00232; Belongs to the glycosyl hydrolase 1 family. (459 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (448 aa)
CPF_2645Putative glycogen debranching enzyme, archaeal type; Identified by match to protein family HMM PF06202; match to protein family HMM TIGR01561. (672 aa)
glgPGlycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (787 aa)
malQ4-alpha-glucanotransferase; Identified by similarity to SP:P29851; match to protein family HMM PF02446; match to protein family HMM TIGR00217. (497 aa)
CPF_2648Glycosyl hydrolase, family 31; Identified by match to protein family HMM PF01055; Belongs to the glycosyl hydrolase 31 family. (715 aa)
nagBGlucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (242 aa)
gapNGlyceraldehyde-3-phosphate dehydrogenase, NADP-dependent; Identified by similarity to SP:Q59931; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. (482 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the trans [...] (454 aa)
spoVGStage V sporulation protein G; Could be involved in septation. (90 aa)
purRPur operon repressor; Identified by similarity to SP:P37551; match to protein family HMM PF00156; match to protein family HMM PF09182; match to protein family HMM TIGR01743. (267 aa)
CPF_2902PTS system, lactose/cellobiose-specific IIA component; Identified by match to protein family HMM PF02255. (103 aa)
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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