STRINGSTRING
arcC arcC xpt xpt pyk pyk deoB deoB CPF_0386 CPF_0386 CPF_0635 CPF_0635 CPF_0671 CPF_0671 purE purE purC purC purF purF purM purM purN purN purH purH purD purD nrdD nrdD CPF_1281 CPF_1281 ade ade xpt-2 xpt-2 CPF_1559 CPF_1559 deoD deoD prs prs CPF_1916 CPF_1916 purB purB gmk gmk CPF_2065 CPF_2065 CPF_2127 CPF_2127 CPF_2150 CPF_2150 relA relA apt apt CPF_2206 CPF_2206 CPF_2207 CPF_2207 hpt2 hpt2 ndk ndk CPF_2260 CPF_2260 CPF_2266 CPF_2266 pyk-2 pyk-2 CPF_2418 CPF_2418 CPF_2535 CPF_2535 guaA guaA guaB guaB nrdB nrdB nrdA nrdA adk adk hpt1 hpt1 prsA prsA punA punA add add nrdD-2 nrdD-2 purA purA
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arcCCarbamate kinase; Identified by match to protein family HMM PF00696; match to protein family HMM TIGR00746; Belongs to the carbamate kinase family. (314 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
pykPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (467 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (396 aa)
CPF_0386Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
CPF_0635Identified by match to protein family HMM PF04607. (263 aa)
CPF_0671Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. (1266 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by similarity to SP:P12046; match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. (235 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (473 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Identified by similarity to SP:P12043; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878. (333 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. (501 aa)
purDPhosphoribosylamine--glycine ligase; Identified by similarity to SP:P12039; match to protein family HMM PF01071; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. (416 aa)
nrdDAnaerobic ribonucleoside-triphosphate reductase; Identified by similarity to GB:CAA10041.1; match to protein family HMM TIGR02487. (603 aa)
CPF_1281Pyruvate kinase barrel domain protein; Identified by match to protein family HMM PF00224; Belongs to the pyruvate kinase family. (360 aa)
adePutative adenine deaminase; Identified by similarity to SP:P39761; match to protein family HMM PF01979; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (568 aa)
xpt-2Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (192 aa)
CPF_1559Putative adenylate cyclase; Identified by match to protein family HMM PF01928. (187 aa)
deoDPurine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. (235 aa)
prsRibose-phosphate pyrophosphokinase; Identified by similarity to SP:P08330; match to protein family HMM PF00156; match to protein family HMM TIGR01251; Belongs to the ribose-phosphate pyrophosphokinase family. (364 aa)
CPF_1916Identified by match to protein family HMM PF02541. (502 aa)
purBAdenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (216 aa)
CPF_2065Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. (176 aa)
CPF_2127Identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (575 aa)
CPF_2150Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293. (184 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (726 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
CPF_2206Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; match to protein family HMM TIGR01167. (1181 aa)
CPF_2207Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; match to protein family HMM TIGR01167. (1215 aa)
hpt2Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (174 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
CPF_2260Nucleoside hydrolase, IUNH family; Identified by similarity to SP:P33022; match to protein family HMM PF01156. (326 aa)
CPF_2266Identified by similarity to GB:BAC98488.1; match to protein family HMM PF01966; match to protein family HMM TIGR01353; Belongs to the dGTPase family. Type 2 subfamily. (342 aa)
pyk-2Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (474 aa)
CPF_2418Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; match to protein family HMM TIGR01167; Belongs to the 5'-nucleotidase family. (724 aa)
CPF_2535Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (204 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (509 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
nrdBRibonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (344 aa)
nrdARibonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (743 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
hpt1Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
punAPurine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
addAdenosine deaminase; Identified by similarity to SP:P22333; match to protein family HMM PF00962; match to protein family HMM TIGR01430; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (332 aa)
nrdD-2Anaerobic ribonucleoside-triphosphate reductase; Identified by similarity to SP:P28903; match to protein family HMM PF03477; match to protein family HMM TIGR02487. (705 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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