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| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (294 aa) |
| | plc | Phospholipase C; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes. (398 aa) |
| | CPF_0061 | Putative D-3-phosphoglycerate dehydrogenase; Identified by similarity to SP:P35136; match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (301 aa) |
| | CPF_0076 | Putative glucokinase; Identified by similarity to SP:P54495; match to protein family HMM PF00480. (315 aa) |
| | CPF_0081 | Putative fructose-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167. (281 aa) |
| | CPF_0085 | Myo-inositol 2-dehydrogenase; Identified by similarity to GB:AAC70005.1; match to protein family HMM PF01408; match to protein family HMM PF02894. (335 aa) |
| | CPF_0088 | Oxidoreductase, Gfo/Idh/MocA family; Identified by match to protein family HMM PF01408; match to protein family HMM PF02894. (349 aa) |
| | CPF_0092 | butyryl-CoA dehydrogenase; Identified by similarity to SP:P52042; match to protein family HMM PF00441; match to protein family HMM PF02770; match to protein family HMM PF02771; match to protein family HMM PF08028. (378 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa) |
| | arcA | Arginine deiminase; Identified by match to protein family HMM PF02274; match to protein family HMM TIGR01078. (413 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (331 aa) |
| | metC | Cystathionine beta-lyase; Identified by similarity to GB:AAF14695.1; match to protein family HMM PF01053. (384 aa) |
| | CPF_0170 | Identified by similarity to SP:P37887; match to protein family HMM PF00291. (302 aa) |
| | CPF_0205 | Heme oxygenase; Identified by match to protein family HMM PF01126. (214 aa) |
| | CPF_0292 | Putative transketolase, N-terminal subunit; Identified by similarity to SP:Q58094; match to protein family HMM PF00456. (274 aa) |
| | CPF_0293 | Putative transketolase, C-terminal subunit; Identified by similarity to SP:Q58092; match to protein family HMM PF02779; match to protein family HMM PF02780. (314 aa) |
| | CPF_0310 | Putative glycolate oxidase, subunit GlcD; Identified by match to protein family HMM PF01565; match to protein family HMM PF02913. (466 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | pyk | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (467 aa) |
| | hdc | Histidine decarboxylase, pyruvoyl type; Identified by match to protein family HMM PF02329; match to protein family HMM TIGR00541. (320 aa) |
| | CPF_0386 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa) |
| | CPF_0411 | Oxidoreductase, FAD-binding; Identified by match to protein family HMM PF01266; match to protein family HMM PF04324. (473 aa) |
| | CPF_0421 | Putative oligo-1,6-glucosidase; Identified by similarity to SP:P29094; match to protein family HMM PF00128. (554 aa) |
| | CPF_0451 | Alcohol dehydrogenase, iron-containing; Identified by match to protein family HMM PF00465. (382 aa) |
| | rfbA | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (189 aa) |
| | rfbD | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (294 aa) |
| | rfbB | dTDP-glucose 4,6-dehydratase; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (349 aa) |
| | galU | UTP-glucose-1-phosphate uridylyltransferase; Identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099. (306 aa) |
| | galU-2 | UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to SP:Q05852; match to protein family HMM PF00483; match to protein family HMM TIGR01099. (314 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (371 aa) |
| | ribE | Riboflavin synthase, alpha subunit; Identified by similarity to SP:P50854; match to protein family HMM PF00677; match to protein family HMM TIGR00187. (217 aa) |
| | ribA | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (399 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa) |
| | rfbA-2 | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa) |
| | rfbB-2 | dTDP-glucose 4,6-dehydratase; Identified by similarity to SP:P55295; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (349 aa) |
| | CPF_0671 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. (1266 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by similarity to SP:P12046; match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. (235 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (473 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Identified by similarity to SP:P12043; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878. (333 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. (501 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Identified by similarity to SP:P12039; match to protein family HMM PF01071; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. (416 aa) |
| | argH | Argininosuccinate lyase; Identified by similarity to SP:O34858; match to protein family HMM PF00206; match to protein family HMM TIGR00838. (466 aa) |
| | argG | Argininosuccinate synthase; Identified by match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (403 aa) |
| | tal | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase; Identified by similarity to SP:P39912; match to protein family HMM PF00793; match to protein family HMM TIGR01361. (337 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (350 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (424 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (357 aa) |
| | CPF_0691 | Chorismate mutase; Identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805. (97 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa) |
| | scrK | Fructokinase; Identified by similarity to GB:AAC99323.1; match to protein family HMM PF00294. (310 aa) |
| | panE | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | CPF_0801 | Sensory box protein/histidinol phosphate phosphatase family protein; Identified by similarity to SP:O34411; match to protein family HMM PF00990; match to protein family HMM PF02811; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254; match to protein family HMM TIGR01856. (624 aa) |
| | CPF_0802 | Glycosyl hydrolase, family 13; Identified by match to protein family HMM PF00128; match to protein family HMM PF02903; Belongs to the glycosyl hydrolase 13 family. (610 aa) |
| | glxK | Glycerate kinase; Identified by similarity to SP:Q9Z9P2; match to protein family HMM PF02595; match to protein family HMM TIGR00045; Belongs to the glycerate kinase type-1 family. (373 aa) |
| | CPF_1087 | Identified by match to protein family HMM PF00128; match to protein family HMM PF02368; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF07523; match to protein family HMM TIGR01167; match to protein family HMM TIGR02104; Belongs to the glycosyl hydrolase 13 family. (2638 aa) |
| | CPF_1117 | Glycosyl hydrolase, family 65; Identified by match to protein family HMM PF03632; match to protein family HMM PF03633; match to protein family HMM PF03636. (780 aa) |
| | CPF_1229 | Histidinol phosphate phosphatase family protein; Identified by similarity to SP:O34411; match to protein family HMM PF02811; match to protein family HMM TIGR01856; Belongs to the PHP hydrolase family. HisK subfamily. (261 aa) |
| | CPF_1232 | Conserved hypothetical protein; Identified by similarity to GB:AAU17187.1. (339 aa) |
| | sdhB | L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. (226 aa) |
| | sdhA | L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by similarity to SP:P33073; match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. (292 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (552 aa) |
| | CPF_1281 | Pyruvate kinase barrel domain protein; Identified by match to protein family HMM PF00224; Belongs to the pyruvate kinase family. (360 aa) |
| | hisK | Histidinol-phosphatase; Identified by similarity to SP:O34411; match to protein family HMM PF02811; match to protein family HMM TIGR01856; Belongs to the PHP hydrolase family. HisK subfamily. (274 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to SP:P71019; match to protein family HMM PF00698; match to protein family HMM TIGR00128. (314 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (163 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (271 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (282 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (310 aa) |
| | tdcB | Threonine dehydratase, catabolic; Identified by similarity to SP:P05792; match to protein family HMM PF00291; match to protein family HMM PF01842; match to protein family HMM TIGR01127. (402 aa) |
| | pfkA-2 | Phosphofructokinase family protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (365 aa) |
| | manA | Mannose-6-phosphate isomerase, class I; Identified by similarity to SP:Q59935; match to protein family HMM PF01238; match to protein family HMM TIGR00218. (325 aa) |
| | gltA | Glutamate synthase (NADPH), homotetrameric; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01316. (468 aa) |
| | xpt-2 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (192 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | pgk | Phosphoglycerate kinase; Identified by similarity to SP:P40924; match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (397 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type I; Identified by similarity to SP:Q59309; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa) |
| | plsD | Sn-glycerol-3-phosphate acyltransferase; Identified by similarity to GB:AAC46006.1; match to protein family HMM PF01553. (234 aa) |
| | cysE | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. (169 aa) |
| | cysK | Cysteine synthase A; Identified by similarity to SP:P37887; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa) |
| | pssA | CDP-diacylglycerol--serine O-phosphatidyltransferase; Identified by similarity to SP:P39823; match to protein family HMM PF01066; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (173 aa) |
| | CPF_1551 | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (340 aa) |
| | fba | Fructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (288 aa) |
| | deoD | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. (235 aa) |
| | CPF_1668 | ACT domain protein; Identified by similarity to SP:P21204; match to protein family HMM PF01842; Belongs to the UPF0735 family. (145 aa) |
| | CPF_1670 | Identified by match to protein family HMM PF02574. (279 aa) |
| | CPF_1671 | Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase; Identified by match to protein family HMM PF01553; match to protein family HMM TIGR00530; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (242 aa) |
| | hemL | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00713. (425 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Identified by similarity to SP:P30950; match to protein family HMM PF00490; Belongs to the ALAD family. (321 aa) |
| | hemD | uroporphyrinogen-III methyltransferase/synthase; Identified by similarity to GB:AAK00606.1; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469. (492 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (291 aa) |
| | CPF_1689 | Identified by match to protein family HMM TIGR01470. (208 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (400 aa) |
| | pfp | Phosphofructokinase family protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (400 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Identified by similarity to GB:AAF64593.1; match to protein family HMM PF01063; match to protein family HMM TIGR01123. (341 aa) |
| | CPF_1782 | Fructokinase; Identified by similarity to GB:AAC99323.1; match to protein family HMM PF00294. (315 aa) |
| | CPF_1783 | Sucrose-6-phosphate dehydrogenase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (487 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Identified by similarity to SP:P08330; match to protein family HMM PF00156; match to protein family HMM TIGR01251; Belongs to the ribose-phosphate pyrophosphokinase family. (364 aa) |
| | pulA | Pullulanase, type I; Identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; Belongs to the glycosyl hydrolase 13 family. (655 aa) |
| | CPF_1809 | Putative undecaprenyl diphosphate synthase; Identified by match to protein family HMM PF01255. (213 aa) |
| | CPF_1839 | Putative pullulanase; Identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; Belongs to the glycosyl hydrolase 13 family. (1064 aa) |
| | glgB | 1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (659 aa) |
| | axe1 | Acetylxylan esterase; Identified by similarity to GB:AAB68821.1; match to protein family HMM PF05448. (319 aa) |
| | purB | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | aspB | Aspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. (397 aa) |
| | CPF_1932 | Aspartokinase; Identified by similarity to SP:Q04795; match to protein family HMM PF00696; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (398 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Identified by match to protein family HMM PF01467; match to protein family HMM PF01687; match to protein family HMM PF06574; match to protein family HMM TIGR00083; Belongs to the ribF family. (309 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (349 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Identified by similarity to SP:O31752; match to protein family HMM PF01148; Belongs to the CDS family. (267 aa) |
| | uppS | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (253 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (76 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (339 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa) |
| | CPF_2005 | L-asparaginase; Identified by match to protein family HMM PF00710. (327 aa) |
| | gpsA | NAD-dependent glycerol-3-phosphate dehydrogenase family protein; Identified by similarity to SP:P46919; match to protein family HMM PF01210; match to protein family HMM PF03721; match to protein family HMM PF03807; match to protein family HMM PF07479; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (331 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (619 aa) |
| | ispA | Geranyltranstransferase; Identified by similarity to SP:Q08291; match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. (290 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (272 aa) |
| | CPF_2127 | Identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (575 aa) |
| | CPF_2132 | FMN-dependent dehydrogenase; Identified by match to protein family HMM PF01070; match to protein family HMM PF01791. (340 aa) |
| | CPF_2137 | Putative histidinol-phosphatase; Identified by similarity to SP:Q02150; match to protein family HMM PF02811; match to protein family HMM TIGR01856; Belongs to the PHP hydrolase family. HisK subfamily. (262 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (325 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (254 aa) |
| | CPF_2182 | Identified by similarity to SP:P51831; match to protein family HMM PF00106. (248 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa) |
| | CPF_2206 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; match to protein family HMM TIGR01167. (1181 aa) |
| | CPF_2207 | Identified by match to protein family HMM PF00149; match to protein family HMM PF02872; match to protein family HMM TIGR01167. (1215 aa) |
| | CPF_2212 | Transcriptional regulator, GntR family/aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00392. (468 aa) |
| | hpt2 | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (174 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | asnA | Aspartate--ammonia ligase; Identified by similarity to SP:P00963; match to protein family HMM PF03590; match to protein family HMM TIGR00669. (336 aa) |
| | ppdK | Pyruvate, phosphate dikinase; Identified by similarity to SP:P22983; match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family. (876 aa) |
| | CPF_2274 | Identified by similarity to SP:P19638; match to protein family HMM PF01219; match to protein family HMM PF01569. (232 aa) |
| | CPF_2293 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (377 aa) |
| | CPF_2315 | Glutamate decarboxylase; Identified by match to protein family HMM PF00282; match to protein family HMM TIGR01788; Belongs to the group II decarboxylase family. (464 aa) |
| | nifJ | Pyruvate-flavodoxin oxidoreductase; Identified by similarity to SP:P19543; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176. (1171 aa) |
| | fabV | Alcohol dehydrogenase, short-chain family; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (389 aa) |
| | CPF_2333 | Alpha-glucosidase; Identified by similarity to SP:Q9F234; match to protein family HMM PF01055; Belongs to the glycosyl hydrolase 31 family. (746 aa) |
| | CPF_2361 | Putative membrane protein; Identified by similarity to GB:AAO35611.1; match to protein family HMM PF07456. (171 aa) |
| | pyk-2 | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (474 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (391 aa) |
| | CPF_2460 | acetyl-CoA acetyltransferase; Identified by similarity to SP:P45359; match to protein family HMM PF00108; match to protein family HMM PF02803; match to protein family HMM TIGR01930; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | rpiB | Ribose 5-phosphate isomerase B; Identified by similarity to SP:P37351; match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (149 aa) |
| | ispE | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (288 aa) |
| | CPF_2488 | Conserved hypothetical protein; Identified by similarity to GB:AAO35611.1; match to protein family HMM PF07456. (176 aa) |
| | pgi | Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (450 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | bcd | butyryl-CoA dehydrogenase; Identified by similarity to SP:P52042; match to protein family HMM PF00441; match to protein family HMM PF02770; match to protein family HMM PF02771; match to protein family HMM PF08028. (379 aa) |
| | CPF_2607 | Identified by match to protein family HMM PF00483. (269 aa) |
| | CPF_2610 | Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. (458 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (156 aa) |
| | glgP | Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (787 aa) |
| | malQ | 4-alpha-glucanotransferase; Identified by similarity to SP:P29851; match to protein family HMM PF02446; match to protein family HMM TIGR00217. (497 aa) |
| | CPF_2648 | Glycosyl hydrolase, family 31; Identified by match to protein family HMM PF01055; Belongs to the glycosyl hydrolase 31 family. (715 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (225 aa) |
| | CPF_2776 | Pyridine nucleotide-disulphide oxidoreductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992. (413 aa) |
| | hpt1 | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | punA | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa) |
| | adhE | Aldehyde-alcohol dehydrogenase; Identified by similarity to SP:P33744; match to protein family HMM PF00171; match to protein family HMM PF00465; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (865 aa) |
| | CPF_2875 | FAD-dependent oxidoreductase; Identified by match to protein family HMM PF01266; match to protein family HMM PF04324. (476 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (269 aa) |
| | sdhB-2 | L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. (226 aa) |
| | sdhA-2 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by similarity to SP:P33073; match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. (293 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
