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CPF_0061 CPF_0061 CPF_0076 CPF_0076 CPF_0081 CPF_0081 CPF_0090 CPF_0090 CPF_0092 CPF_0092 CPF_0095 CPF_0095 arcC arcC CPF_0170 CPF_0170 ackA ackA CPF_0292 CPF_0292 CPF_0293 CPF_0293 pfkA pfkA pyk pyk CPF_0397 CPF_0397 CPF_0398 CPF_0398 CPF_0518 CPF_0518 tal tal CPF_1232 CPF_1232 sdhB sdhB sdhA sdhA CPF_1281 CPF_1281 accB accB accC accC accD accD accA accA ppcA ppcA tdcB tdcB pfkA-2 pfkA-2 eno eno gpmI gpmI tpiA tpiA pgk pgk gap gap cysE cysE cysK cysK fba fba pfp pfp prs prs ackA-2 ackA-2 pta pta rpe rpe narB narB folD folD glyA glyA ppdK ppdK nifJ nifJ fabV fabV pyk-2 pyk-2 CPF_2460 CPF_2460 rpiB rpiB pgi pgi hbd hbd bcd bcd crt crt gapN gapN fhs fhs prsA prsA sdhB-2 sdhB-2 sdhA-2 sdhA-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CPF_0061Putative D-3-phosphoglycerate dehydrogenase; Identified by similarity to SP:P35136; match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (301 aa)
CPF_0076Putative glucokinase; Identified by similarity to SP:P54495; match to protein family HMM PF00480. (315 aa)
CPF_0081Putative fructose-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167. (281 aa)
CPF_00903-hydroxybutyryl-CoA dehydratase; Identified by similarity to SP:P52046; match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
CPF_0092butyryl-CoA dehydrogenase; Identified by similarity to SP:P52042; match to protein family HMM PF00441; match to protein family HMM PF02770; match to protein family HMM PF02771; match to protein family HMM PF08028. (378 aa)
CPF_0095Identified by match to protein family HMM PF02733; match to protein family HMM PF02734; match to protein family HMM TIGR02363; match to protein family HMM TIGR02365. (582 aa)
arcCCarbamate kinase; Identified by match to protein family HMM PF00696; match to protein family HMM TIGR00746; Belongs to the carbamate kinase family. (314 aa)
CPF_0170Identified by similarity to SP:P37887; match to protein family HMM PF00291. (302 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
CPF_0292Putative transketolase, N-terminal subunit; Identified by similarity to SP:Q58094; match to protein family HMM PF00456. (274 aa)
CPF_0293Putative transketolase, C-terminal subunit; Identified by similarity to SP:Q58092; match to protein family HMM PF02779; match to protein family HMM PF02780. (314 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
pykPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (467 aa)
CPF_03972-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; Identified by match to protein family HMM PF01081; match to protein family HMM TIGR01182. (213 aa)
CPF_0398Kinase, pfkB family; Identified by match to protein family HMM PF00294. (339 aa)
CPF_0518NAD-dependent 4-hydroxybutyrate dehydrogenase; Identified by match to protein family HMM PF00465. (371 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa)
CPF_1232Conserved hypothetical protein; Identified by similarity to GB:AAU17187.1. (339 aa)
sdhBL-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. (226 aa)
sdhAL-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by similarity to SP:P33073; match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. (292 aa)
CPF_1281Pyruvate kinase barrel domain protein; Identified by match to protein family HMM PF00224; Belongs to the pyruvate kinase family. (360 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (163 aa)
accCacetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (271 aa)
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (537 aa)
tdcBThreonine dehydratase, catabolic; Identified by similarity to SP:P05792; match to protein family HMM PF00291; match to protein family HMM PF01842; match to protein family HMM TIGR01127. (402 aa)
pfkA-2Phosphofructokinase family protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (365 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
pgkPhosphoglycerate kinase; Identified by similarity to SP:P40924; match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (397 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Identified by similarity to SP:Q59309; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
cysESerine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. (169 aa)
cysKCysteine synthase A; Identified by similarity to SP:P37887; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa)
fbaFructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (288 aa)
pfpPhosphofructokinase family protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (400 aa)
prsRibose-phosphate pyrophosphokinase; Identified by similarity to SP:P08330; match to protein family HMM PF00156; match to protein family HMM TIGR01251; Belongs to the ribose-phosphate pyrophosphokinase family. (364 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
ptaPhosphate acetyltransferase; Identified by match to protein family HMM PF01515; match to protein family HMM TIGR00651. (333 aa)
rpeRibulose-phosphate 3-epimerase; Identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (217 aa)
narBNitrate reductase electron transfer subunit; Identified by match to protein family HMM PF00037. (137 aa)
folDfolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (277 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa)
ppdKPyruvate, phosphate dikinase; Identified by similarity to SP:P22983; match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family. (876 aa)
nifJPyruvate-flavodoxin oxidoreductase; Identified by similarity to SP:P19543; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176. (1171 aa)
fabVAlcohol dehydrogenase, short-chain family; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (389 aa)
pyk-2Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (474 aa)
CPF_2460acetyl-CoA acetyltransferase; Identified by similarity to SP:P45359; match to protein family HMM PF00108; match to protein family HMM PF02803; match to protein family HMM TIGR01930; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
rpiBRibose 5-phosphate isomerase B; Identified by similarity to SP:P37351; match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (149 aa)
pgiGlucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (450 aa)
hbd3-hydroxybutyryl-CoA dehydrogenase; Identified by similarity to SP:P52041; match to protein family HMM PF00725; match to protein family HMM PF02737. (282 aa)
bcdbutyryl-CoA dehydrogenase; Identified by similarity to SP:P52042; match to protein family HMM PF00441; match to protein family HMM PF02770; match to protein family HMM PF02771; match to protein family HMM PF08028. (379 aa)
crt3-hydroxybutyryl-CoA dehydratase; Identified by similarity to SP:P52046; match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
gapNGlyceraldehyde-3-phosphate dehydrogenase, NADP-dependent; Identified by similarity to SP:Q59931; match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. (482 aa)
fhsFormate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
sdhB-2L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. (226 aa)
sdhA-2L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by similarity to SP:P33073; match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. (293 aa)
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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