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upp upp tmk tmk Noca_0542 Noca_0542 folD1 folD1 Noca_0642 Noca_0642 Noca_0674 Noca_0674 Noca_0829 Noca_0829 Noca_0926 Noca_0926 Noca_1033 Noca_1033 Noca_1289 Noca_1289 Noca_1299 Noca_1299 Noca_1513 Noca_1513 Noca_1631 Noca_1631 Noca_1635 Noca_1635 Noca_2047 Noca_2047 Noca_2307 Noca_2307 Noca_2321 Noca_2321 Noca_2322 Noca_2322 glyA glyA apt apt pyrR pyrR pyrB pyrB pyrC pyrC carA carA carB carB pyrD pyrD pyrF pyrF Noca_2434 Noca_2434 gmk gmk Noca_2608 Noca_2608 gcvP gcvP gcvH gcvH dut dut Noca_2919 Noca_2919 Noca_3144 Noca_3144 ndk ndk purE purE purK purK Noca_3521 Noca_3521 Noca_3531 Noca_3531 add add Noca_3535 Noca_3535 Noca_3537 Noca_3537 folD2 folD2 purH purH purN purN guaA guaA Noca_3640 Noca_3640 guaB guaB Noca_3811 Noca_3811 Noca_3838 Noca_3838 purM purM purF purF purL purL purQ purQ purS purS purC purC Noca_4341 Noca_4341 purD purD purA purA pyrE pyrE dcd dcd fhs fhs Noca_4570 Noca_4570
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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Your Input:
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (213 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (222 aa)
Noca_0542PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: ccr:CC1928 inosine-uridine preferring nucleoside hydrolase. (329 aa)
folD1Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa)
Noca_0642PFAM: FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: jan:Jann_2849 FAD dependent oxidoreductase; Belongs to the GcvT family. (815 aa)
Noca_0674KEGG: tfu:Tfu_2662 adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase. (343 aa)
Noca_0829PFAM: glutamine amidotransferase class-I; KEGG: sai:Saci_1154 hypothetical protein. (232 aa)
Noca_0926PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: sma:SAV3537 putative MazG-family transcriptional regulator. (233 aa)
Noca_1033PFAM: aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: tac:Ta0575 probable aspartate carbamoyltransferase, catalytic chain. (291 aa)
Noca_1289PFAM: protein of unknown function DUF179; KEGG: sma:SAV5129 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (191 aa)
Noca_1299PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sco:SCO2015 putative nucleotidase; Belongs to the 5'-nucleotidase family. (615 aa)
Noca_1513TIGRFAM: purine nucleoside phosphorylase; PFAM: purine and other phosphorylases, family 1; KEGG: oih:OB2345 purine nucleoside phosphorylase. (243 aa)
Noca_1631KEGG: pho:PH0720 aspartate carbamoyltransferase catalytic chain; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (317 aa)
Noca_1635Dihydropyrimidinase; KEGG: sus:Acid_7659 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. (467 aa)
Noca_2047PFAM: glutamine amidotransferase class-I; KEGG: sco:SCO0603 amino transferase. (240 aa)
Noca_2307TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: fra:Francci3_3132 glycine cleavage system T protein. (371 aa)
Noca_2321PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: cgb:cg0397 probable 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. (731 aa)
Noca_2322PFAM: Endonuclease/exonuclease/phosphatase; KEGG: cjk:jk1043 putative extracellular nuclease. (929 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (482 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (204 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: sco:SCO1487 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (324 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (432 aa)
carAKEGG: sco:SCO1484 carbamoyl-phosphate synthase, pyrimidine-specific, small chain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; Belongs to the CarA family. (378 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: sco:SCO1483 carbamoylphosphate synthetase large chain; Belongs to the CarB family. (1143 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (355 aa)
pyrFTIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: sma:SAV6869 putative orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (273 aa)
Noca_2434Hypothetical protein. (143 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (194 aa)
Noca_2608IMP dehydrogenase family protein; KEGG: sma:SAV6884 putative inosine monophosphate dehydrogenase; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. (478 aa)
gcvPGlycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (971 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (148 aa)
Noca_2919PFAM: thymidine kinase; KEGG: sco:SCO5845 putative thimidine kinase. (217 aa)
Noca_3144PFAM: PfkB domain protein; KEGG: sco:SCO2158 kinase. (327 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (135 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (179 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (399 aa)
Noca_3521Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (273 aa)
Noca_3531Uridine kinase; KEGG: sma:SAV3350 ATP-binding protein. (203 aa)
addKEGG: sco:SCO4901 putative adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (373 aa)
Noca_3535KEGG: sma:SAV3365 putative thymidine phosphorylase; TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain. (428 aa)
Noca_3537Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa)
folD2Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
purHKEGG: sma:SAV3444 putative bifunctional purine biosynthesis protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. (525 aa)
purNFormyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (527 aa)
Noca_3640TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase; KEGG: sma:SAV5001 putative inosine-5'-monophosphate dehydrogenase. (368 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
Noca_3811Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (956 aa)
Noca_3838PFAM: FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: sit:TM1040_0434 FAD dependent oxidoreductase; Belongs to the GcvT family. (827 aa)
purMKEGG: sco:SCO4087 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (362 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (514 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (751 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (85 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: sma:SAV4146 putative phosphoribosylaminoimidazole-succinocar boxamide synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (284 aa)
Noca_4341Adenylosuccinate lyase; KEGG: sco:SCO1254 putative adenylosuccino lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
purDPhosphoribosylamine--glycine ligase; KEGG: sma:SAV4149 putative phosphoribosylglycinamide synthetase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (416 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa)
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
fhsPFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: gbe:GbCGDNIH1_0047 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (559 aa)
Noca_4570PFAM: glutamine amidotransferase class-I; KEGG: jan:Jann_1856 glutamine amidotransferase class-I. (243 aa)
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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