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Noca_0032 Noca_0032 Noca_0036 Noca_0036 Noca_0113 Noca_0113 purU purU pckG pckG Noca_0198 Noca_0198 Noca_0203 Noca_0203 Noca_0280 Noca_0280 Noca_0536 Noca_0536 Noca_0537 Noca_0537 Noca_0585 Noca_0585 purU-2 purU-2 Noca_0733 Noca_0733 Noca_0888 Noca_0888 Noca_0987 Noca_0987 fumC fumC Noca_1061 Noca_1061 Noca_1116 Noca_1116 Noca_1184 Noca_1184 Noca_1185 Noca_1185 Noca_1188 Noca_1188 Noca_1727 Noca_1727 Noca_2034 Noca_2034 Noca_2358 Noca_2358 Noca_2359 Noca_2359 Noca_2360 Noca_2360 Noca_2361 Noca_2361 Noca_2876 Noca_2876 Noca_3513 Noca_3513 Noca_3547 Noca_3547 Noca_3548 Noca_3548 Noca_3551 Noca_3551 Noca_3552 Noca_3552 Noca_3553 Noca_3553 Noca_3575 Noca_3575 mdh mdh sucD sucD sucC sucC Noca_4004 Noca_4004 Noca_4075 Noca_4075 pckG-2 pckG-2 Noca_4175 Noca_4175 pckG-3 pckG-3 Noca_4598 Noca_4598
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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co-expression
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Your Input:
Noca_0032PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; KEGG: mka:MK0828 succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (532 aa)
Noca_0036PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rxy:Rxyl_2477 thiamine pyrophosphate enzyme-like TPP binding region; Belongs to the TPP enzyme family. (543 aa)
Noca_0113Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: tfu:Tfu_2390 malate dehydrogenase (oxaloacetate decarboxylating). (457 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa)
Noca_0198PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: sil:SPO1469 3-ketosteroid dehydrogenase, putative. (436 aa)
Noca_0203PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; KEGG: bbr:BB3064 hypothetical protein. (470 aa)
Noca_0280(S)-2-hydroxy-acid oxidase; PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: nfa:nfa32960 putative L-lactate dehydrogenase. (410 aa)
Noca_0536PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: sma:SAV4876 2-oxoglutarate ferredoxin oxidoreductase, beta subunit. (371 aa)
Noca_0537PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tfu:Tfu_2674 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (660 aa)
Noca_0585Monoamine oxidase-like protein; KEGG: mxa:MXAN_4930 amine oxidase, flavin-containing. (137 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
Noca_0733PFAM: Citrate synthase; KEGG: sma:SAV3859 putative citrate synthase; Belongs to the citrate synthase family. (368 aa)
Noca_0888KEGG: rxy:Rxyl_1676 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (447 aa)
Noca_0987KEGG: tfu:Tfu_0863 pyruvate phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing enzyme; pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; Belongs to the PEP-utilizing enzyme family. (897 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
Noca_1061Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (571 aa)
Noca_1116Succinate semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase; KEGG: mes:Meso_4451 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (482 aa)
Noca_1184PFAM: PEP-utilising enzyme, mobile region; KEGG: bsu:BG14114 similar to pyruvate,water dikinase. (592 aa)
Noca_1185Pyruvate, water dikinase; PFAM: pyruvate phosphate dikinase, PEP/pyruvate-binding; KEGG: mka:MK0252 phosphoenolpyruvate synthase/pyruvate phosphate dikinase. (275 aa)
Noca_1188PFAM: aldehyde dehydrogenase; KEGG: rha:RHA1_ro00658 succinate-semialdehyde dehydrogenase (NAD(P)+). (461 aa)
Noca_1727Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: sma:SAV2981 putative malate dehydrogenase. (396 aa)
Noca_2034Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rha:RHA1_ro00492 malate dehydrogenase (oxaloacetate-decarboxylating). (461 aa)
Noca_2358PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: rfr:Rfer_2184 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate. (544 aa)
Noca_2359Pyruvate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: rfr:Rfer_2185 thiamine pyrophosphate enzyme-like TPP-binding. (334 aa)
Noca_2360Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rfr:Rfer_2186 pyruvate flavodoxin/ferredoxin oxidoreductase-like. (401 aa)
Noca_2361TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: rfr:Rfer_2187 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate. (190 aa)
Noca_2876Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (938 aa)
Noca_3513Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1128 aa)
Noca_3547TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; KEGG: rha:RHA1_ro01048 succinate dehydrogenase iron-sulfur protein. (258 aa)
Noca_3548PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mpa:MAP3698c probable succinate dehydrogenase. (621 aa)
Noca_3551TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; KEGG: tfu:Tfu_2453 succinate dehydrogenase, cytochrome b558 subunit. (233 aa)
Noca_3552KEGG: tfu:Tfu_2452 succinate dehydrogenase or fumarate reductase, flavoprotein subunit, low-GC gram-positive bacteria; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (672 aa)
Noca_3553TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: tfu:Tfu_2451 putative succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (247 aa)
Noca_3575Isocitrate dehydrogenase, NADP-dependent; KEGG: sma:SAV7214 putative isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (737 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
Noca_4004PFAM: aldehyde dehydrogenase; KEGG: nfa:nfa46640 putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (519 aa)
Noca_4075PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sfr:Sfri_2586 flavocytochrome c. (484 aa)
pckG-2Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (614 aa)
Noca_4175PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mpa:MAP3255 pyruvate decarboxylase; Belongs to the TPP enzyme family. (593 aa)
pckG-3Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (617 aa)
Noca_4598PFAM: aldehyde dehydrogenase; KEGG: rha:RHA1_ro02683 succinate-semialdehyde dehydrogenase (NAD(P)+); Belongs to the aldehyde dehydrogenase family. (485 aa)
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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