STRINGSTRING
Noca_0116 Noca_0116 pckG pckG acsA acsA Noca_0536 Noca_0536 Noca_0537 Noca_0537 Noca_0860 Noca_0860 eno eno Noca_0987 Noca_0987 Noca_1003 Noca_1003 Noca_1066 Noca_1066 Noca_1184 Noca_1184 Noca_1185 Noca_1185 Noca_1993 Noca_1993 Noca_2092 Noca_2092 Noca_2105 Noca_2105 Noca_2304 Noca_2304 Noca_2359 Noca_2359 Noca_2360 Noca_2360 Noca_2361 Noca_2361 Noca_2363 Noca_2363 Noca_2454 Noca_2454 Noca_2530 Noca_2530 pgk pgk tpiA tpiA Noca_2539 Noca_2539 Noca_3020 Noca_3020 pfp pfp Noca_3108 Noca_3108 Noca_3109 Noca_3109 Noca_3322 Noca_3322 Noca_3398 Noca_3398 Noca_3518 Noca_3518 Noca_3529 Noca_3529 Noca_3634 Noca_3634 gpmA gpmA pckG-2 pckG-2 Noca_4350 Noca_4350 Noca_4438 Noca_4438 Noca_4453 Noca_4453 pckG-3 pckG-3 Noca_4485 Noca_4485 Noca_4507 Noca_4507 Noca_4508 Noca_4508 Noca_4509 Noca_4509
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Noca_0116Polyphosphate glucokinase; PFAM: ROK family protein; KEGG: lxx:Lxx09960 glucokinase. (252 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (664 aa)
Noca_0536PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: sma:SAV4876 2-oxoglutarate ferredoxin oxidoreductase, beta subunit. (371 aa)
Noca_0537PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tfu:Tfu_2674 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (660 aa)
Noca_0860PFAM: AMP-dependent synthetase and ligase; KEGG: rxy:Rxyl_1704 AMP-dependent synthetase and ligase. (541 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
Noca_0987KEGG: tfu:Tfu_0863 pyruvate phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing enzyme; pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; Belongs to the PEP-utilizing enzyme family. (897 aa)
Noca_1003PFAM: fructose-bisphosphate aldolase, class-I; KEGG: bxe:Bxe_B1334 fructose-bisphosphate aldolase. (339 aa)
Noca_1066TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: sma:SAV3215 putative glycerol-inducible protein. (339 aa)
Noca_1184PFAM: PEP-utilising enzyme, mobile region; KEGG: bsu:BG14114 similar to pyruvate,water dikinase. (592 aa)
Noca_1185Pyruvate, water dikinase; PFAM: pyruvate phosphate dikinase, PEP/pyruvate-binding; KEGG: mka:MK0252 phosphoenolpyruvate synthase/pyruvate phosphate dikinase. (275 aa)
Noca_19932-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (932 aa)
Noca_2092PFAM: aldehyde dehydrogenase; KEGG: sma:SAV7177 putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
Noca_21052-oxo-acid dehydrogenase E1 component homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (892 aa)
Noca_2304TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: tfu:Tfu_0994 dihydrolipoamide dehydrogenase. (459 aa)
Noca_2359Pyruvate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: rfr:Rfer_2185 thiamine pyrophosphate enzyme-like TPP-binding. (334 aa)
Noca_2360Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rfr:Rfer_2186 pyruvate flavodoxin/ferredoxin oxidoreductase-like. (401 aa)
Noca_2361TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: rfr:Rfer_2187 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate. (190 aa)
Noca_2363PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: mmc:Mmcs_3405 alcohol dehydrogenase GroES-like protein. (354 aa)
Noca_2454PFAM: Aldose 1-epimerase; KEGG: fal:FRAAL2426 putative aldose-1-epimerase. (307 aa)
Noca_2530KEGG: cdi:DIP1310 glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: sco:SCO1946 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (264 aa)
Noca_2539PFAM: phosphoglucose isomerase (PGI); KEGG: lxx:Lxx11600 glucose-6-phosphate isomerase; Belongs to the GPI family. (555 aa)
Noca_3020PFAM: pyruvate kinase; KEGG: sma:SAV6217 putative pyruvate kinase; Belongs to the pyruvate kinase family. (487 aa)
pfpPyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (408 aa)
Noca_3108Glucokinase; PFAM: ROK family protein; KEGG: tfu:Tfu_0273 glucokinase ROK. (335 aa)
Noca_3109Glucokinase; TIGRFAM: putative glucokinase, ROK family; PFAM: ROK family protein; KEGG: fal:FRAAL5091 putative glucokinase (glucose kinase). (313 aa)
Noca_3322PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: pto:PTO1249 alcohol dehydrogenase. (338 aa)
Noca_3398PFAM: Aldose 1-epimerase; KEGG: tfu:Tfu_1083 putative aldose-1-epimerase. (294 aa)
Noca_3518TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: pac:PPA1227 dihydrolipoamide dehydrogenase. (464 aa)
Noca_3529PFAM: aldehyde dehydrogenase; KEGG: sco:SCO4913 putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (484 aa)
Noca_3634PFAM: aldehyde dehydrogenase; KEGG: mpa:MAP2338 hypothetical protein. (480 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (247 aa)
pckG-2Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (614 aa)
Noca_4350Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
Noca_4438TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: mpa:MAP3146c phosphoglucomutase. (564 aa)
Noca_4453PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: gbe:GbCGDNIH1_1185 dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (427 aa)
pckG-3Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (617 aa)
Noca_4485PFAM: ROK family protein; KEGG: blo:BL1341 possible sugar kinase. (305 aa)
Noca_4507PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: sco:SCO3815 putative dihydrolipoamide acyltransferase component. (474 aa)
Noca_4508PFAM: Transketolase, central region; Transketolase domain protein; KEGG: sco:SCO3816 putative branched-chain alpha keto acid dehydrogenase E1 beta subunit. (326 aa)
Noca_4509PFAM: dehydrogenase, E1 component; KEGG: tfu:Tfu_0180 pyruvate dehydrogenase (lipoamide). (398 aa)
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.