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Noca_0113 Noca_0113 Noca_0148 Noca_0148 Noca_0185 Noca_0185 pckG pckG Noca_0198 Noca_0198 Noca_0203 Noca_0203 Noca_0280 Noca_0280 acsA acsA Noca_0536 Noca_0536 Noca_0537 Noca_0537 Noca_0860 Noca_0860 Noca_0987 Noca_0987 fumC fumC Noca_1061 Noca_1061 Noca_1184 Noca_1184 Noca_1185 Noca_1185 Noca_1371 Noca_1371 Noca_1650 Noca_1650 Noca_1727 Noca_1727 Noca_1797 Noca_1797 Noca_1828 Noca_1828 leuA leuA Noca_1986 Noca_1986 Noca_1993 Noca_1993 Noca_2000 Noca_2000 Noca_2034 Noca_2034 Noca_2092 Noca_2092 Noca_2105 Noca_2105 Noca_2150 Noca_2150 Noca_2304 Noca_2304 Noca_2359 Noca_2359 Noca_2360 Noca_2360 Noca_2361 Noca_2361 Noca_2396 Noca_2396 Noca_2734 Noca_2734 Noca_2740 Noca_2740 Noca_2764 Noca_2764 Noca_2847 Noca_2847 Noca_2937 Noca_2937 ackA ackA Noca_2954 Noca_2954 Noca_3020 Noca_3020 Noca_3364 Noca_3364 Noca_3510 Noca_3510 Noca_3513 Noca_3513 Noca_3518 Noca_3518 Noca_3529 Noca_3529 mdh mdh Noca_3634 Noca_3634 Noca_4075 Noca_4075 Noca_4108 Noca_4108 Noca_4142 Noca_4142 pckG-2 pckG-2 Noca_4175 Noca_4175 acyP acyP Noca_4453 Noca_4453 pckG-3 pckG-3 Noca_4507 Noca_4507 Noca_4508 Noca_4508 Noca_4509 Noca_4509 Noca_4563 Noca_4563
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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Noca_0113Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: tfu:Tfu_2390 malate dehydrogenase (oxaloacetate decarboxylating). (457 aa)
Noca_0148Carbamoyl-phosphate synthase L chain, ATP-binding protein; PFAM: biotin/lipoyl attachment domain-containing protein; phosphoribosylglycinamide synthetase; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: rso:RSc0265 probable acyl-CoA carboxylase alpha chain protein. (634 aa)
Noca_0185PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: fra:Francci3_3765 biotin/lipoyl attachment. (77 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa)
Noca_0198PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: sil:SPO1469 3-ketosteroid dehydrogenase, putative. (436 aa)
Noca_0203PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; KEGG: bbr:BB3064 hypothetical protein. (470 aa)
Noca_0280(S)-2-hydroxy-acid oxidase; PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: nfa:nfa32960 putative L-lactate dehydrogenase. (410 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (664 aa)
Noca_0536PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: sma:SAV4876 2-oxoglutarate ferredoxin oxidoreductase, beta subunit. (371 aa)
Noca_0537PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tfu:Tfu_2674 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (660 aa)
Noca_0860PFAM: AMP-dependent synthetase and ligase; KEGG: rxy:Rxyl_1704 AMP-dependent synthetase and ligase. (541 aa)
Noca_0987KEGG: tfu:Tfu_0863 pyruvate phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing enzyme; pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; Belongs to the PEP-utilizing enzyme family. (897 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
Noca_1061Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (571 aa)
Noca_1184PFAM: PEP-utilising enzyme, mobile region; KEGG: bsu:BG14114 similar to pyruvate,water dikinase. (592 aa)
Noca_1185Pyruvate, water dikinase; PFAM: pyruvate phosphate dikinase, PEP/pyruvate-binding; KEGG: mka:MK0252 phosphoenolpyruvate synthase/pyruvate phosphate dikinase. (275 aa)
Noca_1371KEGG: sma:SAV3512 putative thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
Noca_1650Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (314 aa)
Noca_1727Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: sma:SAV2981 putative malate dehydrogenase. (396 aa)
Noca_1797acetyl-CoA acetyltransferase; KEGG: nfa:nfa10750 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
Noca_1828acetyl-CoA acetyltransferase; KEGG: nfa:nfa34130 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (580 aa)
Noca_1986Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: mmc:Mmcs_3368 propionyl-CoA carboxylase. (476 aa)
Noca_19932-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (932 aa)
Noca_2000KEGG: rxy:Rxyl_2107 hypothetical protein. (526 aa)
Noca_2034Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rha:RHA1_ro00492 malate dehydrogenase (oxaloacetate-decarboxylating). (461 aa)
Noca_2092PFAM: aldehyde dehydrogenase; KEGG: sma:SAV7177 putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
Noca_21052-oxo-acid dehydrogenase E1 component homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (892 aa)
Noca_2150Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (314 aa)
Noca_2304TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: tfu:Tfu_0994 dihydrolipoamide dehydrogenase. (459 aa)
Noca_2359Pyruvate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: rfr:Rfer_2185 thiamine pyrophosphate enzyme-like TPP-binding. (334 aa)
Noca_2360Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rfr:Rfer_2186 pyruvate flavodoxin/ferredoxin oxidoreductase-like. (401 aa)
Noca_2361TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: rfr:Rfer_2187 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate. (190 aa)
Noca_2396PFAM: beta-lactamase domain protein; KEGG: sco:SCO1509 hydrolase. (237 aa)
Noca_2734PFAM: peptidase M22, glycoprotease; KEGG: nfa:nfa5210 putative lipid-transfer protein. (388 aa)
Noca_2740acetyl-CoA acetyltransferase; KEGG: rha:RHA1_ro04678 probable thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (388 aa)
Noca_2764KEGG: rha:RHA1_ro04599 probable acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
Noca_2847KEGG: aci:ACIAD1977 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
Noca_2937PFAM: beta-lactamase domain protein; SMART: Rhodanese domain protein; KEGG: rha:RHA1_ro11243 hypothetical protein. (452 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
Noca_2954Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
Noca_3020PFAM: pyruvate kinase; KEGG: sma:SAV6217 putative pyruvate kinase; Belongs to the pyruvate kinase family. (487 aa)
Noca_3364KEGG: sco:SCO5529 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa)
Noca_3510PFAM: biotin/lipoyl attachment domain-containing protein; phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: tfu:Tfu_2557 putative acyl-CoA carboxylase, alpha subunit. (590 aa)
Noca_3513Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1128 aa)
Noca_3518TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: pac:PPA1227 dihydrolipoamide dehydrogenase. (464 aa)
Noca_3529PFAM: aldehyde dehydrogenase; KEGG: sco:SCO4913 putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (484 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
Noca_3634PFAM: aldehyde dehydrogenase; KEGG: mpa:MAP2338 hypothetical protein. (480 aa)
Noca_4075PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sfr:Sfri_2586 flavocytochrome c. (484 aa)
Noca_4108PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: pst:PSPTO_4243 UreA amidolyase-related protein. (72 aa)
Noca_4142KEGG: rha:RHA1_ro01876 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
pckG-2Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (614 aa)
Noca_4175PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mpa:MAP3255 pyruvate decarboxylase; Belongs to the TPP enzyme family. (593 aa)
acyPPFAM: acylphosphatase; KEGG: tko:TK2031 acylphosphatase. (99 aa)
Noca_4453PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: gbe:GbCGDNIH1_1185 dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (427 aa)
pckG-3Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (617 aa)
Noca_4507PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: sco:SCO3815 putative dihydrolipoamide acyltransferase component. (474 aa)
Noca_4508PFAM: Transketolase, central region; Transketolase domain protein; KEGG: sco:SCO3816 putative branched-chain alpha keto acid dehydrogenase E1 beta subunit. (326 aa)
Noca_4509PFAM: dehydrogenase, E1 component; KEGG: tfu:Tfu_0180 pyruvate dehydrogenase (lipoamide). (398 aa)
Noca_4563KEGG: sco:SCO6731 acetyl-CoA acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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