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Noca_0148 Noca_0148 Noca_0185 Noca_0185 Noca_0288 Noca_0288 acsA acsA Noca_0437 Noca_0437 Noca_0645 Noca_0645 Noca_0798 Noca_0798 Noca_0799 Noca_0799 Noca_0802 Noca_0802 Noca_0860 Noca_0860 Noca_1247 Noca_1247 Noca_1248 Noca_1248 Noca_1249 Noca_1249 Noca_1250 Noca_1250 Noca_1371 Noca_1371 Noca_1796 Noca_1796 Noca_1797 Noca_1797 Noca_1802 Noca_1802 Noca_1828 Noca_1828 Noca_1986 Noca_1986 Noca_2127 Noca_2127 Noca_2128 Noca_2128 Noca_2131 Noca_2131 Noca_2304 Noca_2304 Noca_2359 Noca_2359 Noca_2360 Noca_2360 Noca_2361 Noca_2361 Noca_2726 Noca_2726 Noca_2734 Noca_2734 Noca_2740 Noca_2740 Noca_2743 Noca_2743 Noca_2764 Noca_2764 Noca_2847 Noca_2847 ackA ackA Noca_2954 Noca_2954 Noca_3205 Noca_3205 Noca_3495 Noca_3495 Noca_3510 Noca_3510 Noca_3518 Noca_3518 Noca_3544 Noca_3544 Noca_3545 Noca_3545 sucD sucD sucC sucC Noca_3591 Noca_3591 Noca_4108 Noca_4108 Noca_4139 Noca_4139 Noca_4142 Noca_4142 Noca_4454 Noca_4454 Noca_4551 Noca_4551 Noca_4562 Noca_4562 Noca_4563 Noca_4563 Noca_4626 Noca_4626
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
Noca_0148Carbamoyl-phosphate synthase L chain, ATP-binding protein; PFAM: biotin/lipoyl attachment domain-containing protein; phosphoribosylglycinamide synthetase; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: rso:RSc0265 probable acyl-CoA carboxylase alpha chain protein. (634 aa)
Noca_0185PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: fra:Francci3_3765 biotin/lipoyl attachment. (77 aa)
Noca_0288PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nfa:nfa50130 putative enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (664 aa)
Noca_0437PFAM: acyl-CoA oxidase domain protein; acyl-CoA dehydrogenase domain protein; KEGG: tfu:Tfu_2239 hypothetical protein. (657 aa)
Noca_0645TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; KEGG: mmc:Mmcs_2274 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
Noca_0798KEGG: sus:Acid_6472 methylmalonyl-CoA mutase, large subunit; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (545 aa)
Noca_0799PFAM: cobalamin B12-binding domain protein; KEGG: pfu:PF1946 methylmalonyl-CoAmutase, subunit alpha. (148 aa)
Noca_0802PFAM: Enoyl-CoA hydratase/isomerase; KEGG: fal:FRAAL4766 putative enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa)
Noca_0860PFAM: AMP-dependent synthetase and ligase; KEGG: rxy:Rxyl_1704 AMP-dependent synthetase and ligase. (541 aa)
Noca_1247Conserved carboxylase region; PFAM: pyruvate carboxyltransferase; Conserved carboxylase region; KEGG: sus:Acid_6961 conserved carboxylase region. (517 aa)
Noca_1248PFAM: carboxyl transferase; KEGG: cdi:DIP0740 methylmalonyl-CoA decarboxylase, alpha-subunit. (522 aa)
Noca_1249KEGG: cdi:DIP0741 hypothetical protein. (84 aa)
Noca_1250PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: cdi:DIP0742 putative decarboxylase. (121 aa)
Noca_1371KEGG: sma:SAV3512 putative thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
Noca_1796methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: rha:RHA1_ro01456 possible methylmalonyl-CoA epimerase. (170 aa)
Noca_1797acetyl-CoA acetyltransferase; KEGG: nfa:nfa10750 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
Noca_1802KEGG: sma:SAV2832 putative isobutyryl-CoA mutase, chain A; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (562 aa)
Noca_1828acetyl-CoA acetyltransferase; KEGG: nfa:nfa34130 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
Noca_1986Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: mmc:Mmcs_3368 propionyl-CoA carboxylase. (476 aa)
Noca_2127PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nfa:nfa10390 putative enoyl-CoA hydratase/isomerase family protein. (331 aa)
Noca_2128PFAM: cobalamin B12-binding domain protein; KEGG: hwa:HQ2301A methylmalonyl-CoA mutase, subunit B (cobalamin-binding subunit). (172 aa)
Noca_2131methylmalonyl-CoA mutase; KEGG: pho:PH1306 563aa long hypothetical methylmalonyl-CoA mutase; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (569 aa)
Noca_2304TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: tfu:Tfu_0994 dihydrolipoamide dehydrogenase. (459 aa)
Noca_2359Pyruvate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; KEGG: rfr:Rfer_2185 thiamine pyrophosphate enzyme-like TPP-binding. (334 aa)
Noca_2360Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rfr:Rfer_2186 pyruvate flavodoxin/ferredoxin oxidoreductase-like. (401 aa)
Noca_2361TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: rfr:Rfer_2187 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate. (190 aa)
Noca_2726PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP0549c enoyl-CoA hydratase. (266 aa)
Noca_2734PFAM: peptidase M22, glycoprotease; KEGG: nfa:nfa5210 putative lipid-transfer protein. (388 aa)
Noca_2740acetyl-CoA acetyltransferase; KEGG: rha:RHA1_ro04678 probable thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (388 aa)
Noca_2743PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mpa:MAP0516c enoyl-CoA hydratase. (259 aa)
Noca_2764KEGG: rha:RHA1_ro04599 probable acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
Noca_2847KEGG: aci:ACIAD1977 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
Noca_2954Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
Noca_3205TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; KEGG: rha:RHA1_ro05598 4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa)
Noca_3495PFAM: carboxyl transferase; KEGG: sco:SCO4926 propionyl-CoA carboxylase complex B subunit. (540 aa)
Noca_3510PFAM: biotin/lipoyl attachment domain-containing protein; phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: tfu:Tfu_2557 putative acyl-CoA carboxylase, alpha subunit. (590 aa)
Noca_3518TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: pac:PPA1227 dihydrolipoamide dehydrogenase. (464 aa)
Noca_3544KEGG: sma:SAV2040 putative methylmalonyl-CoA mutase, coenzyme B12-dependent alpha subunit; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase; cobalamin B12-binding domain protein. (720 aa)
Noca_3545PFAM: methylmalonyl-CoA mutase; KEGG: fal:FRAAL4951 methylmalonyl-CoA mutase small subunit (MCM-beta). (569 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
Noca_3591isobutyryl-CoA mutase small subunit; PFAM: cobalamin B12-binding domain protein; KEGG: sco:SCO4800 isobutiryl CoA mutase, small subunit. (143 aa)
Noca_4108PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: pst:PSPTO_4243 UreA amidolyase-related protein. (72 aa)
Noca_4139PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mbo:Mb2855 enoyl-CoA hydratase. (265 aa)
Noca_4142KEGG: rha:RHA1_ro01876 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
Noca_4454PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein; KEGG: bme:BMEII0061 2-oxoisovalerate dehydrogenase alpha and beta subunit. (726 aa)
Noca_4551PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: nfa:nfa53290 putative acetyl/propionyl-CoA carboxylase alpha subunit. (633 aa)
Noca_4562PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 6-phosphogluconate dehydrogenase, NAD-binding; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: mpa:MAP0790 enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxybutyryl-CoA epimerase. (736 aa)
Noca_4563KEGG: sco:SCO6731 acetyl-CoA acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
Noca_4626TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase; KEGG: mmc:Mmcs_0348 methylmalonate-semialdehyde dehydrogenase. (498 aa)
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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