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| | Noca_0033 | PFAM: dihydrodipicolinate synthetase; KEGG: sco:SCO1889 dihydropicolinate synthase; Belongs to the DapA family. (305 aa) |
| | Noca_0036 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: rxy:Rxyl_2477 thiamine pyrophosphate enzyme-like TPP binding region; Belongs to the TPP enzyme family. (543 aa) |
| | Noca_0170 | PFAM: prephenate dehydratase; KEGG: rpa:RPA3695 chorismate mutase/prephenate dehydratase. (287 aa) |
| | Noca_0321 | KEGG: tfu:Tfu_0043 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (424 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (374 aa) |
| | Noca_0733 | PFAM: Citrate synthase; KEGG: sma:SAV3859 putative citrate synthase; Belongs to the citrate synthase family. (368 aa) |
| | Noca_0830 | PFAM: glutamine synthetase, catalytic region; KEGG: bja:bll1069 probable glutamine synthetase. (497 aa) |
| | Noca_0888 | KEGG: rxy:Rxyl_1676 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (447 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (347 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa) |
| | Noca_0939 | KEGG: rha:RHA1_ro05843 probable cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (462 aa) |
| | Noca_0976 | Cystathionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: tfu:Tfu_0440 cystathionine gamma-synthase. (387 aa) |
| | Noca_0979 | L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: sco:SCO4962 threonine dehydratase. (404 aa) |
| | Noca_1003 | PFAM: fructose-bisphosphate aldolase, class-I; KEGG: bxe:Bxe_B1334 fructose-bisphosphate aldolase. (339 aa) |
| | Noca_1175 | PFAM: Transaldolase; KEGG: pac:PPA0454 transaldolase. (371 aa) |
| | Noca_1191 | PFAM: GCN5-related N-acetyltransferase; FR47 domain protein; KEGG: sma:SAV3130 acetyltransferase. (296 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (320 aa) |
| | Noca_1200 | TIGRFAM: succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: tfu:Tfu_0495 succinyl-diaminopimelate desuccinylase. (354 aa) |
| | Noca_1627 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mta:Moth_2000 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (507 aa) |
| | Noca_1628 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: hal:VNG2430G threonine synthase. (461 aa) |
| | Noca_1697 | TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase; KEGG: pac:PPA1271 putative inositol monophosphatase. (291 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | Noca_1710 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: tfu:Tfu_0553 acetolactate synthase large subunit. (551 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (466 aa) |
| | Noca_1744 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: tfu:Tfu_2424 homoserine dehydrogenase. (441 aa) |
| | Noca_1745 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (365 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (429 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (580 aa) |
| | Noca_2046 | PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp; KEGG: sco:SCO2241 probable glutamine synthetase. (455 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa) |
| | Noca_2295 | KEGG: pac:PPA0671 glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (474 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (482 aa) |
| | Noca_2367 | PFAM: aminotransferase, class IV; KEGG: sco:SCO1546 putative aminotransferase. (274 aa) |
| | Noca_2410 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein; KEGG: sma:SAV6853 putative shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (270 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (392 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (183 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (365 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (334 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa) |
| | Noca_2446 | PFAM: ribulose-phosphate 3-epimerase; KEGG: sco:SCO1464 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lxx:Lxx11210 phosphoribosyl-ATP pyrophosphatase. (87 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa) |
| | argJ | N-acetylglutamate synthase / glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (312 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class-III; KEGG: nfa:nfa19390 putative acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (411 aa) |
| | argF-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (306 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: sco:SCO7036 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (477 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: tfu:Tfu_2051 argininosuccinate lyase. (470 aa) |
| | Noca_2499 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase of the AroH class; KEGG: sma:SAV6520 putative chorismate mutase. (128 aa) |
| | Noca_2500 | Prephenate dehydrogenase; PFAM: amino acid-binding ACT domain protein; Prephenate dehydrogenase; KEGG: lxx:Lxx05720 prephenate dehydrogenase. (361 aa) |
| | Noca_2530 | KEGG: cdi:DIP1310 glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: sco:SCO1946 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (264 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (370 aa) |
| | Noca_2541 | TIGRFAM: transketolase; PFAM: Transketolase domain protein; Transketolase, central region; KEGG: rha:RHA1_ro07186 transketolase; Belongs to the transketolase family. (714 aa) |
| | Noca_2574 | KEGG: sco:SCO1808 putative phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3. (420 aa) |
| | Noca_2587 | PFAM: glutamine synthetase, catalytic region; KEGG: rxy:Rxyl_3196 glutamate--ammonia ligase. (464 aa) |
| | Noca_2631 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1244 aa) |
| | Noca_2876 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (938 aa) |
| | Noca_3020 | PFAM: pyruvate kinase; KEGG: sma:SAV6217 putative pyruvate kinase; Belongs to the pyruvate kinase family. (487 aa) |
| | Noca_3021 | TIGRFAM: glutamate synthases, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sma:SAV6190 putative glutamate synthase small chain. (493 aa) |
| | Noca_3022 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: sco:SCO2026 putative glutamate synthase large subunit. (1519 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (426 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: tfu:Tfu_1164 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (123 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. (244 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: blo:BL1297 imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: tfu:Tfu_1151 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | Noca_3092 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: tfu:Tfu_1039 phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2. (370 aa) |
| | Noca_3094 | L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; KEGG: sth:STH2403 threonine aldolase. (331 aa) |
| | Noca_3096 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; KEGG: sma:SAV6086 putative 2-dehydro-3-deoxyphosphoheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase, class II; Belongs to the class-II DAHP synthase family. (445 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (247 aa) |
| | Noca_3221 | PFAM: Saccharopine dehydrogenase; KEGG: mmc:Mmcs_4946 saccharopine dehydrogenase. (407 aa) |
| | Noca_3292 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: cgb:cg3086 putative L,L-cystathionine gamma-lyase. (359 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa) |
| | Noca_3306 | PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: afu:AF2100 acetolactate synthase large subunit. (588 aa) |
| | Noca_3363 | Acetylornithine deacetylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: sru:SRU_2799 acetylornithine deacetylase. (375 aa) |
| | Noca_3364 | KEGG: sco:SCO5529 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa) |
| | Noca_3367 | KEGG: xcb:XC_3380 branched-chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV. (357 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (478 aa) |
| | Noca_3385 | KEGG: sco:SCO5515 probable D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (536 aa) |
| | ilvC-2 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa) |
| | Noca_3391 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: fal:FRAAL5850 acetolactate synthase III, valine-sensitive, small subunit. (184 aa) |
| | Noca_3392 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: tfu:Tfu_0611 acetolactate synthase, large subunit, biosynthetic type. (585 aa) |
| | ilvD | KEGG: rha:RHA1_ro05087 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (567 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (371 aa) |
| | Noca_3483 | Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerases, RpiB/LacA/LacB family; ribose 5-phosphate isomerase; PFAM: Ribose/galactose isomerase; KEGG: sma:SAV5426 putative ribose-5-phosphate isomerase. (162 aa) |
| | Noca_3513 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1128 aa) |
| | Noca_3575 | Isocitrate dehydrogenase, NADP-dependent; KEGG: sma:SAV7214 putative isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (737 aa) |
| | metXS | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (369 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa) |
| | Noca_3949 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (451 aa) |
| | Noca_3951 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (397 aa) |
| | Noca_3987 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: tfu:Tfu_0226 threonine synthase. (424 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (247 aa) |
| | Noca_4221 | Transketolase subunit B; PFAM: Transketolase, central region; Transketolase domain protein; KEGG: lmf:LMOf2365_1054 transketolase, C-terminal subunit, putative. (307 aa) |
| | Noca_4222 | PFAM: Transketolase domain protein; KEGG: tma:TM0954 transketolase, N-terminal subunit. (270 aa) |
| | Noca_4306 | TIGRFAM: serine O-acetyltransferase; KEGG: pfo:Pfl_4614 serine O-acetyltransferase. (202 aa) |
| | Noca_4307 | TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mpa:MAP2123 cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa) |
| | Noca_4350 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa) |
| | Noca_4355 | Succinyldiaminopimelate aminotransferase apoenzyme; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; KEGG: sma:SAV4517 putative aminotransferase. (385 aa) |
| | Noca_4506 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: bce:BC2248 acetylornithine deacetylase. (428 aa) |
| | pat | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (356 aa) |
| | Noca_4528 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cgb:cg1134 para-aminobenzoate synthase component I and II. (187 aa) |
| | Noca_4578 | Aminotransferase, class I and II; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; KEGG: rha:RHA1_ro08885 probable aminotransferase. (386 aa) |
