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dnaA dnaA Noca_0106 Noca_0106 Noca_0113 Noca_0113 Noca_0165 Noca_0165 Noca_0192 Noca_0192 Noca_0194 Noca_0194 Noca_0198 Noca_0198 Noca_0203 Noca_0203 Noca_0313 Noca_0313 Noca_0332 Noca_0332 Noca_0333 Noca_0333 Noca_0334 Noca_0334 Noca_0339 Noca_0339 Noca_0723 Noca_0723 Noca_0749 Noca_0749 Noca_0766 Noca_0766 Noca_0767 Noca_0767 csrA csrA Noca_0830 Noca_0830 Noca_0884 Noca_0884 Noca_0917 Noca_0917 Noca_0920 Noca_0920 Noca_0942 Noca_0942 Noca_0943 Noca_0943 Noca_0945 Noca_0945 Noca_1118 Noca_1118 Noca_1121 Noca_1121 Noca_1212 Noca_1212 Noca_1251 Noca_1251 Noca_1337 Noca_1337 Noca_1346 Noca_1346 Noca_1347 Noca_1347 Noca_1348 Noca_1348 Noca_1349 Noca_1349 Noca_1356 Noca_1356 Noca_1371 Noca_1371 Noca_1433 Noca_1433 Noca_1434 Noca_1434 Noca_1641 Noca_1641 Noca_1727 Noca_1727 Noca_1797 Noca_1797 Noca_1828 Noca_1828 Noca_1864 Noca_1864 Noca_1865 Noca_1865 Noca_1931 Noca_1931 Noca_1933 Noca_1933 Noca_2034 Noca_2034 Noca_2046 Noca_2046 Noca_2295 Noca_2295 Noca_2543 Noca_2543 Noca_2587 Noca_2587 Noca_2734 Noca_2734 Noca_2740 Noca_2740 Noca_2764 Noca_2764 Noca_2847 Noca_2847 Noca_2944 Noca_2944 Noca_2984 Noca_2984 Noca_2995 Noca_2995 Noca_3120 Noca_3120 glnD glnD Noca_3268 Noca_3268 Noca_3501 Noca_3501 Noca_3595 Noca_3595 Noca_3597 Noca_3597 Noca_3598 Noca_3598 cheB cheB Noca_3603 Noca_3603 Noca_3604 Noca_3604 Noca_3819 Noca_3819 Noca_4045 Noca_4045 Noca_4046 Noca_4046 Noca_4075 Noca_4075 Noca_4079 Noca_4079 Noca_4142 Noca_4142 Noca_4263 Noca_4263 Noca_4317 Noca_4317 Noca_4394 Noca_4394 Noca_4422 Noca_4422 Noca_4450 Noca_4450 Noca_4517 Noca_4517 Noca_4519 Noca_4519 Noca_4520 Noca_4520 Noca_4542 Noca_4542 Noca_4563 Noca_4563 Noca_4617 Noca_4617
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (528 aa)
Noca_0106PFAM: peptidase M15B and M15C, D,D-carboxypeptidase VanY/endolysins; KEGG: mmc:Mmcs_0342 peptidase M15B and M15C, D,D-carboxypeptidase VanY/endolysins. (209 aa)
Noca_0113Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: tfu:Tfu_2390 malate dehydrogenase (oxaloacetate decarboxylating). (457 aa)
Noca_0165PFAM: cyclic nucleotide-binding; KEGG: mmc:Mmcs_2490 cyclic nucleotide-binding protein. (124 aa)
Noca_0192Phosphate ABC transporter substrate-binding protein, PhoT family; TIGRFAM: phosphate binding protein; KEGG: tth:TTC1726 phosphate-binding protein; TC 3.A.1.7.1. (312 aa)
Noca_0194PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: sth:STH749 two-component sensor kinase, probably involved in phosphate sensing. (549 aa)
Noca_0198PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: sil:SPO1469 3-ketosteroid dehydrogenase, putative. (436 aa)
Noca_0203PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; KEGG: bbr:BB3064 hypothetical protein. (470 aa)
Noca_0313PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: rha:RHA1_ro11204 histidine kinase. (363 aa)
Noca_0332RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: lxx:Lxx06230 RNA polymerase, sigma factor. (278 aa)
Noca_0333PFAM: sigma-70 region 4 domain protein; KEGG: lxx:Lxx06230 RNA polymerase, sigma factor. (268 aa)
Noca_0334RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: lxx:Lxx06230 RNA polymerase, sigma factor. (300 aa)
Noca_0339PFAM: cyclic nucleotide-binding; regulatory protein, Crp; KEGG: tfu:Tfu_0117 cyclic nucleotide-binding:bacterial regulatory protein, Crp. (225 aa)
Noca_0723PFAM: glycoside hydrolase, family 5; KEGG: sma:SAV1854 endo-1,4-beta-glucanase; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (362 aa)
Noca_0749PFAM: MotA/TolQ/ExbB proton channel; KEGG: dsy:DSY3032 hypothetical protein. (255 aa)
Noca_0766Flagellin domain protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (376 aa)
Noca_0767RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: xac:XAC1933 RNA polymerase sigma factor for flagellar operon FliA. (285 aa)
csrACarbon storage regulator; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (83 aa)
Noca_0830PFAM: glutamine synthetase, catalytic region; KEGG: bja:bll1069 probable glutamine synthetase. (497 aa)
Noca_0884PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: rha:RHA1_ro05624 possible serine protease, C-terminal. (417 aa)
Noca_0917Phosphate ABC transporter substrate-binding protein, PhoT family; TIGRFAM: phosphate ABC transporter, periplasmic phosphate-binding protein; KEGG: fal:FRAAL6535 high-affinity phosphate transport protein (ABC superfamily); TC 3.A.1.7.1. (544 aa)
Noca_0920KEGG: cya:CYA_1212 phosphate uptake transporter (PhoT) ABC transporter family, substrate-binding protein; TC 3.A.1.7.1. (509 aa)
Noca_0942PFAM: cytochrome bd ubiquinol oxidase, subunit I; KEGG: lxx:Lxx12300 cytochrome D ubiquinol oxidase subunit I. (484 aa)
Noca_0943TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase, subunit II; KEGG: sco:SCO3946 putative cytochrome oxidase subunit II. (342 aa)
Noca_0945PFAM: regulatory protein, LuxR; response regulator receiver; KEGG: fra:Francci3_3253 two component transcriptional regulator, LuxR family. (216 aa)
Noca_1118RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: sco:SCO5621 RNA polymerase sigma factor WhiG. (244 aa)
Noca_1121Hypothetical protein; KEGG: sat:SYN_00814 tfp pilus assembly protein, major pilin. (140 aa)
Noca_1212PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: fra:Francci3_0069 peptidase S1 and S6, chymotrypsin/Hap. (471 aa)
Noca_1251PFAM: Fibronectin, type III domain protein; KEGG: mbo:Mb0063 possible cellulase CelA1 (endoglucanase) (endo-1,4-beta-glucanase) (fi-cmcase) (carboxymethyl cellulase); Belongs to the glycosyl hydrolase family 6. (497 aa)
Noca_1337PFAM: regulatory protein, LuxR; KEGG: sco:SCO0421 two-component response regulator. (188 aa)
Noca_1346TIGRFAM: nitrate reductase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: sco:SCO6535 putative nitrate reductase alpha chain NarG; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1240 aa)
Noca_1347TIGRFAM: nitrate reductase, beta subunit; KEGG: mmc:Mmcs_1262 nitrate reductase, beta subunit. (584 aa)
Noca_1348TIGRFAM: nitrate reductase molybdenum cofactor assembly chaperone; PFAM: Nitrate reductase, delta subunit; KEGG: nfa:nfa45510 putative nitrate reductase delta subunit. (236 aa)
Noca_1349TIGRFAM: respiratory nitrate reductase, gamma subunit; PFAM: Nitrate reductase, gamma subunit; KEGG: mbo:Mb1765c probable nitrate reductase NarX. (242 aa)
Noca_1356PFAM: regulatory protein, LuxR; response regulator receiver; KEGG: mmc:Mmcs_1056 two component transcriptional regulator, LuxR family. (217 aa)
Noca_1371KEGG: sma:SAV3512 putative thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
Noca_1433PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sco:SCO3013 putative two-component system response regulator. (248 aa)
Noca_1434PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: sco:SCO3012 putative two-component system histidine kinase. (544 aa)
Noca_1641PFAM: cyclic nucleotide-binding; regulatory protein, Crp; KEGG: rxy:Rxyl_1332 transcriptional regulator, Crp/Fnr family. (267 aa)
Noca_1727Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: sma:SAV2981 putative malate dehydrogenase. (396 aa)
Noca_1797acetyl-CoA acetyltransferase; KEGG: nfa:nfa10750 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
Noca_1828acetyl-CoA acetyltransferase; KEGG: nfa:nfa34130 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
Noca_1864PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: fal:FRAAL5304 sensory histidine kinase in two-component regulatory system wtih KdpE, regulation of potassium translocation. (371 aa)
Noca_1865PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sco:SCO5872 putative turgor pressure regulator. (224 aa)
Noca_1931PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: sth:STH843 two-component sensor histidine kinase. (423 aa)
Noca_1933PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: sth:STH843 two-component sensor histidine kinase. (535 aa)
Noca_2034Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: rha:RHA1_ro00492 malate dehydrogenase (oxaloacetate-decarboxylating). (461 aa)
Noca_2046PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp; KEGG: sco:SCO2241 probable glutamine synthetase. (455 aa)
Noca_2295KEGG: pac:PPA0671 glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (474 aa)
Noca_2543PFAM: cytochrome oxidase assembly; KEGG: fra:Francci3_1653 cytochrome oxidase assembly. (305 aa)
Noca_2587PFAM: glutamine synthetase, catalytic region; KEGG: rxy:Rxyl_3196 glutamate--ammonia ligase. (464 aa)
Noca_2734PFAM: peptidase M22, glycoprotease; KEGG: nfa:nfa5210 putative lipid-transfer protein. (388 aa)
Noca_2740acetyl-CoA acetyltransferase; KEGG: rha:RHA1_ro04678 probable thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (388 aa)
Noca_2764KEGG: rha:RHA1_ro04599 probable acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
Noca_2847KEGG: aci:ACIAD1977 putative acyl-CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
Noca_2944PFAM: Cytochrome b/b6, N-terminal domain; KEGG: oih:OB1775 menaquinol-cytochrome-c reductase cytochrome b subunit. (342 aa)
Noca_2984Chemotaxis sensory transducer; PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: aba:Acid345_1672 methyl-accepting chemotaxis sensory transducer. (545 aa)
Noca_2995PFAM: UDP-glucose/GDP-mannose dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: pfu:PF1631 NDP-sugar dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (399 aa)
Noca_3120PFAM: regulatory protein, LuxR; response regulator receiver; Sigma-70, region 4 type 2; KEGG: rha:RHA1_ro00150 response regulator, two-component system. (212 aa)
glnD(Protein-PII) uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (707 aa)
Noca_3268PFAM: nitrogen regulatory protein P-II; KEGG: sco:SCO5584 nitrogen regulatory protein P-II; Belongs to the P(II) protein family. (112 aa)
Noca_3501Cellulase; PFAM: glycoside hydrolase, family 6; KEGG: mtc:MT0067 cellulase; Belongs to the glycosyl hydrolase family 6. (346 aa)
Noca_3595PFAM: response regulator receiver; KEGG: gme:Gmet_3119 response regulator receiver domain protein (CheY-like). (120 aa)
Noca_3597PFAM: response regulator receiver; KEGG: aba:Acid345_1527 response regulator receiver protein, CheY. (131 aa)
Noca_3598PFAM: MCP methyltransferase, CheR-type; Methyltransferase type 12; KEGG: aba:Acid345_1529 MCP methyltransferase, CheR-type. (278 aa)
cheBResponse regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (366 aa)
Noca_3603PFAM: CheW domain protein; KEGG: aba:Acid345_1525 CheW protein. (139 aa)
Noca_3604PFAM: CheW domain protein; ATP-binding region, ATPase domain protein domain protein; Signal transducing histidine kinase, homodimeric; Hpt domain protein; KEGG: aba:Acid345_1524 CheA signal transduction histidine kinases. (742 aa)
Noca_3819PFAM: Alkaline phosphatase; KEGG: sco:SCO2068 secreted alkaline phosphatase. (523 aa)
Noca_4045PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: sma:SAV3973 putative two-component system sensor kinase. (384 aa)
Noca_4046PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sco:SCO4230 putative response regulator. (225 aa)
Noca_4075PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sfr:Sfri_2586 flavocytochrome c. (484 aa)
Noca_4079PFAM: HpcH/HpaI aldolase; KEGG: rxy:Rxyl_0366 citryl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (283 aa)
Noca_4142KEGG: rha:RHA1_ro01876 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
Noca_4263Phosphate ABC transporter substrate-binding protein, PhoT family; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (370 aa)
Noca_4317PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; SMART: GAF domain protein; KEGG: sth:STH843 two-component sensor histidine kinase. (600 aa)
Noca_4394Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: fal:FRAAL5522 citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (292 aa)
Noca_4422PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sma:SAV5250 two-component system response regulator. (237 aa)
Noca_4450RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: lxx:Lxx06230 RNA polymerase, sigma factor. (300 aa)
Noca_4517PFAM: low molecular weight phosphotyrosine protein phosphatase; KEGG: tfu:Tfu_2341 protein-tyrosine-phosphatase. (196 aa)
Noca_4519PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: nfa:nfa49640 putative two-component system response regulator. (234 aa)
Noca_4520PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: rha:RHA1_ro05623 sensor kinase, two-component system. (471 aa)
Noca_4542KEGG: rha:RHA1_ro01881 possible tyrosine protein phosphatase. (265 aa)
Noca_4563KEGG: sco:SCO6731 acetyl-CoA acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
Noca_4617Cellulase; PFAM: glycoside hydrolase, family 6; KEGG: mtu:Rv0062 cellulase / endoglucanase; Belongs to the glycosyl hydrolase family 6. (341 aa)
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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