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BAC16813.1 BAC16813.1 recF recF BAC16815.1 BAC16815.1 gyrB gyrB gyrA gyrA dnaX dnaX gene:10740610 gene:10740610 topA topA gene:10740708 gene:10740708 BAC17435.1 BAC17435.1 gene:10741028 gene:10741028 BAC17437.1 BAC17437.1 gene:10741030 gene:10741030 dnaE2 dnaE2 BAC17740.1 BAC17740.1 BAC17778.1 BAC17778.1 xseB xseB xseA xseA BAC17950.1 BAC17950.1 BAC18026.1 BAC18026.1 gene:10741673 gene:10741673 BAC18076.1 BAC18076.1 gene:10741748 gene:10741748 polA polA uvrB uvrB uvrA uvrA uvrC uvrC priA priA BAC18564.1 BAC18564.1 rubB rubB rubA rubA rubC rubC gene:10742197 gene:10742197 lexA lexA recX recX recA recA BAC18825.1 BAC18825.1 gene:10742457 gene:10742457 dinB dinB dnaG dnaG gene:10742678 gene:10742678 gene:10742783 gene:10742783 gene:10743266 gene:10743266 ssb ssb BAC19721.1 BAC19721.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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BAC16813.1Putative DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...] (394 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (398 aa)
BAC16815.1Conserved hypothetical protein; CE0005, similar to AF222789-10|AAF33696.1| percent identity: 39 in 188 aa; Belongs to the UPF0232 family. (193 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (687 aa)
gyrAPutative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (863 aa)
dnaXPutative DNA polymerase III gamma subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (780 aa)
gene:10740610Putative DNA polymerase III. (420 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (999 aa)
gene:10740708DNA polymerase III delta' subunit. (414 aa)
BAC17435.1Hypothetical protein; CE0625. (147 aa)
gene:10741028Uncharacterized protein. (486 aa)
BAC17437.1Hypothetical protein; CE0627. (254 aa)
gene:10741030UmuC domain-containing protein. (800 aa)
dnaE2Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1073 aa)
BAC17740.1Putative ATP-dependent DNA helicase; CE0930, similar to Y15254-6|CAA75552.1| percent identity: 43 in 785 aa. (825 aa)
BAC17778.1Putative ATP-dependent DNA helicase; CE0968, similar to AL022374-5|CAA18513.1| percent identity: 55 in 679 aa. (686 aa)
xseBExodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (82 aa)
xseAPutative exodeoxyribonuclease, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (447 aa)
BAC17950.1Putative transport protein; CE1140, similar to AE007658-2|AAK79432.1| percent identity: 46 in 776 aa. (1007 aa)
BAC18026.1Conserved hypothetical protein; CE1216, similar to AY065402-1|AAL38843.1| percent identity: 25 in 223 aa. (373 aa)
gene:10741673Metallophos domain-containing protein. (391 aa)
BAC18076.1Conserved hypothetical protein; CE1266, similar to AE007006-8|AAK45576.1| percent identity: 31 in 872 aa. (878 aa)
gene:10741748Exonuclease domain-containing protein. (252 aa)
polAPutative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (945 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (701 aa)
uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (954 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (681 aa)
priAConserved hypothetical protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (685 aa)
BAC18564.1Conserved hypothetical protein; CE1754, similar to AB056583-2|BAB64333.1| percent identity: 34 in 708 aa. (886 aa)
rubBHolliday junction DNA-helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (360 aa)
rubAHolliday junction DNA-helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (204 aa)
rubCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (230 aa)
gene:10742197Probable transcriptional regulatory protein CE1776. (283 aa)
lexAPutative SOS response repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (269 aa)
recXRegulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. (210 aa)
recARecombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (386 aa)
BAC18825.1Putative DNA polymerase III epsilon subunit; CE2015, similar to AE005827-2|AAK23502.1| percent identity: 32 in 209 aa. (569 aa)
gene:10742457DNA polymerase III subunit alpha. (1204 aa)
dinBPutative DNA-damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (475 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (645 aa)
gene:10742678DNA_pol3_delta domain-containing protein. (328 aa)
gene:10742783Putative single-strand DNA binding protein. (217 aa)
gene:10743266Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (527 aa)
ssbPutative single-strand binding protein; CE2819, similar to AF349434-1|AAK30583.1| percent identity: 51 in 229 aa. (235 aa)
BAC19721.1Putative phosphoesterase; CE2911, similar to Z99122-1|CAB15521.1| percent identity: 32 in 1150 aa. (1521 aa)
Your Current Organism:
Corynebacterium efficiens
NCBI taxonomy Id: 196164
Other names: C. efficiens YS-314, Corynebacterium efficiens DSM 44549, Corynebacterium efficiens JCM 11189, Corynebacterium efficiens YS-314, Corynebacterium efficiens str. YS-314, Corynebacterium efficiens strain YS-314
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