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miaA miaA BAC16951.1 BAC16951.1 tadA tadA tgt tgt gluQ gluQ BAC17138.1 BAC17138.1 BAC17161.1 BAC17161.1 gene:10740782 gene:10740782 truA truA proS proS rbfA rbfA truB truB rnj rnj miaB miaB BAC18629.1 BAC18629.1 dtd dtd thrS thrS hisS hisS aspS aspS alaS alaS gene:10742168 gene:10742168 fmt fmt BAC18437.1 BAC18437.1 gene:10741977 gene:10741977 tyrS tyrS pheT pheT pheS pheS gene:10741854 gene:10741854 gene:10741831 gene:10741831 gltX gltX rsmH rsmH mnmA mnmA gene:10741715 gene:10741715 argS argS rsmA rsmA metG metG rsmI rsmI trpS trpS gene:10741060 gene:10741060 BAC17465.1 BAC17465.1 tsaD tsaD BAC17407.1 BAC17407.1 ileS ileS BAC18842.1 BAC18842.1 rnc rnc rimM rimM trmD trmD rlmN rlmN glyQS glyQS ybeY ybeY BAC18998.1 BAC18998.1 valS valS rph rph BAC19212.1 BAC19212.1 BAC19271.1 BAC19271.1 cysS-2 cysS-2 BAC19332.1 BAC19332.1 lysS lysS tilS tilS trmB trmB serS serS BAC19603.1 BAC19603.1 gene:10743280 gene:10743280 leuS leuS gene:10743306 gene:10743306 rsmG rsmG rnpA rnpA gene:10740996 gene:10740996
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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miaAPutative tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (301 aa)
BAC16951.1Putative ATP-dependent helicase; CE0141, similar to AJ414156-170|CAC92624.1| percent identity: 35 in 796 aa. (811 aa)
tadAConserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (160 aa)
tgtPutative queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose [...] (457 aa)
gluQPutative glutamyl-tRNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (306 aa)
BAC17138.1Putative ribosomal large subunit pseudouridine synthase C; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (304 aa)
BAC17161.1Hypothetical protein; CE0351. (187 aa)
gene:10740782Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (165 aa)
truAPutative tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (300 aa)
proSProline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...] (588 aa)
rbfAPutative ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (189 aa)
truBtRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (327 aa)
rnjPutative metallo-beta-lactamase superfamily protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (700 aa)
miaBtRNA-2-methylthio-N(6)-dimethylallyladenosine synthase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (600 aa)
BAC18629.1Putative ATP-dependent helicase; CE1819, similar to AE004217-11|AAF94540.1| percent identity: 48 in 1299 aa. (1302 aa)
dtdConserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (144 aa)
thrSPutative threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (720 aa)
hisSHistidine--tRNA ligase. (429 aa)
aspSPutative aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (617 aa)
alaSPutative alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (926 aa)
gene:10742168Putative pre-16S rRNA nuclease; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (204 aa)
fmtMethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (315 aa)
BAC18437.1Conserved hypothetical protein; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (282 aa)
gene:10741977Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (329 aa)
tyrSTyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (421 aa)
pheTPhenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (835 aa)
pheSPutative phenylalanyl-tRNA synthetase alpha chain; CE1520, similar to AL583922-1|CAC30352.1| percent identity: 61 in 348 aa; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (366 aa)
gene:10741854Uncharacterized protein. (202 aa)
gene:10741831CMP/dCMP-type deaminase domain-containing protein. (157 aa)
gltXPutative glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (501 aa)
rsmHConserved hypothetical protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (338 aa)
mnmAPutative tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (365 aa)
gene:10741715YrdC-like domain-containing protein; Belongs to the SUA5 family. (216 aa)
argSArginine--tRNA ligase. (550 aa)
rsmAPutative dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (289 aa)
metGMethionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (613 aa)
rsmIConserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (288 aa)
trpSPutative tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (346 aa)
gene:10741060Putative tRNA (cytidine(34)-2'-O)-methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (173 aa)
BAC17465.1Conserved hypothetical protein; CE0655, similar to AX064831-1|CAC25655.1| percent identity: 49 in 155 aa. (159 aa)
tsaDPutative o-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (344 aa)
BAC17407.1Conserved hypothetical protein; CE0597, similar to AX065799-1|CAC26139.1| percent identity: 71 in 224 aa. (224 aa)
ileSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1103 aa)
BAC18842.1Putative ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (309 aa)
rncPutative ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (255 aa)
rimMRibosome maturation factor RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (169 aa)
trmDPutative tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (291 aa)
rlmNProbable dual-specificity RNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (369 aa)
glyQSPutative glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (473 aa)
ybeYConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (200 aa)
BAC18998.1Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (241 aa)
valSValine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (939 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (245 aa)
BAC19212.1Conserved hypothetical protein; CE2402, similar to AL079348-8|CAB45464.1| percent identity: 33 in 255 aa. (255 aa)
BAC19271.1Putative transcription regulator; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (381 aa)
cysS-2Conserved hypothetical protein; CE2516, similar to AL160331-8|CAB77329.1| percent identity: 55 in 468 aa; Belongs to the class-I aminoacyl-tRNA synthetase family. (479 aa)
BAC19332.1Putative transcription factor; CE2522, similar to AE007169-13|AAK48047.1| percent identity: 75 in 157 aa. (200 aa)
lysSLysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (536 aa)
tilSConserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (313 aa)
trmBtRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (254 aa)
serSSerine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (448 aa)
BAC19603.1Conserved hypothetical protein; CE2793, similar to AX064301-1|CAC25391.1| percent identity: 75 in 339 aa. (340 aa)
gene:10743280UPF0176 protein CE2830; Belongs to the UPF0176 family. (312 aa)
leuSLeucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (957 aa)
gene:10743306Uncharacterized protein. (1281 aa)
rsmGPutative glucose inhibited division protein B; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (209 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (133 aa)
gene:10740996Uncharacterized protein. (167 aa)
Your Current Organism:
Corynebacterium efficiens
NCBI taxonomy Id: 196164
Other names: C. efficiens YS-314, Corynebacterium efficiens DSM 44549, Corynebacterium efficiens JCM 11189, Corynebacterium efficiens YS-314, Corynebacterium efficiens str. YS-314, Corynebacterium efficiens strain YS-314
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