STRINGSTRING
KUN49581.1 KUN49581.1 dnaE dnaE polA polA KUN48286.1 KUN48286.1 KUN48303.1 KUN48303.1 KUN47862.1 KUN47862.1 KUN47832.1 KUN47832.1 KUN47405.1 KUN47405.1 KUN47548.1 KUN47548.1 priA-2 priA-2 dnaN_2 dnaN_2 KUN47138.1 KUN47138.1 KUN46697.1 KUN46697.1 KUN46216.1 KUN46216.1 KUN46302.1 KUN46302.1 KUN46303.1 KUN46303.1 KUN46306.1 KUN46306.1 dnaG dnaG KUN45894.1 KUN45894.1 ssb1 ssb1 KUN44901.1 KUN44901.1 KUN44902.1 KUN44902.1 KUN44957.1 KUN44957.1 KUN45122.1 KUN45122.1 KUN44619.1 KUN44619.1 KUN44320.1 KUN44320.1 topA topA recA recA KUN43789.1 KUN43789.1 lexA_1 lexA_1 KUN43802.1 KUN43802.1 KUN43809.1 KUN43809.1 KUN43825.1 KUN43825.1 KUN43534.1 KUN43534.1 gyrA gyrA gyrB gyrB recF recF dnaN_1 dnaN_1 dnaA dnaA ssb2 ssb2 dnaX dnaX sbcC sbcC sbcD sbcD dinB dinB KUN41211.1 KUN41211.1 KUN39488.1 KUN39488.1 KUN37959.1 KUN37959.1 ssb ssb KUN37258.1 KUN37258.1 AQJ27_46665 AQJ27_46665 KUN35909.1 KUN35909.1 KUN34784.1 KUN34784.1 KUN33798.1 KUN33798.1 AQJ27_49875 AQJ27_49875 KUN33212.1 KUN33212.1 lexA_2 lexA_2 KUN32957.1 KUN32957.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KUN49581.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (695 aa)
dnaEDNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1179 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (909 aa)
KUN48286.1uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
KUN48303.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
KUN47862.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1194 aa)
KUN47832.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
KUN47405.15'-3' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
KUN47548.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
priA-2Primosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (715 aa)
dnaN_2DNA polymerase III subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
KUN47138.1ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (852 aa)
KUN46697.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (678 aa)
KUN46216.1Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology. (737 aa)
KUN46302.1DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1093 aa)
KUN46303.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1201 aa)
KUN46306.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (712 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (634 aa)
KUN45894.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
ssb1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
KUN44901.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (70 aa)
KUN44902.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
KUN44957.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
KUN45122.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
KUN44619.1PBS lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (675 aa)
KUN44320.1DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (937 aa)
recADNA recombination/repair protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (374 aa)
KUN43789.1ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (673 aa)
lexA_1LexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (258 aa)
KUN43802.1Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (732 aa)
KUN43809.1DNA topoisomerase IV subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (707 aa)
KUN43825.1DNA topoisomerase IV; Derived by automated computational analysis using gene prediction method: Protein Homology. (819 aa)
KUN43534.13'-5' exonuclease of DNA polymerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (864 aa)
gyrBDNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (694 aa)
recFRecombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (373 aa)
dnaN_1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
dnaAHypothetical protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (696 aa)
ssb2Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (777 aa)
sbcCExonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (1000 aa)
sbcDDNA exonuclease SbcCD subunit SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (387 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (453 aa)
KUN41211.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
KUN39488.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
KUN37959.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (60 aa)
ssbSingle-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
KUN37258.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AQJ27_46665Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
KUN35909.1DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
KUN34784.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
KUN33798.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (229 aa)
AQJ27_49875UmuC domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
KUN33212.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
lexA_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S24 family. (96 aa)
KUN32957.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (834 aa)
Your Current Organism:
Streptomyces olivochromogenes
NCBI taxonomy Id: 1963
Other names: ATCC 25479, ATCC 3336, Actinomyces olivochromogenus, CBS 889.69, DSM 40451, IFO 13067, IFO 3178, IMET 40352, ISP 5451, JCM 4163, JCM 4500, KCTC 9064, NBRC 13067, NBRC 3178, NRRL-ISP 5451, S. olivochromogenes, Streptomyces olivichromogenes, Streptomyces olivochromogenus
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