STRINGSTRING
hisN hisN Cgl0800 Cgl0800 hisG hisG hisE hisE hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisNInositol monophosphatase; Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine. (260 aa)
Cgl0800Inositol monophosphatase. (291 aa)
hisGATP PHOSPHORIBOSYLTRANSFERASE; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa)
hisEPHOSPHORIBOSYL-ATP CYCLOHYDROLASE. (87 aa)
hisIPROBABLE PHOSPHORIBOSYL-AMP CYCLOHYDROLASE PROTEIN; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (118 aa)
hisFPROBABLE CYCLASE (IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE-SUBUNIT); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (258 aa)
hisAPHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. (246 aa)
hisHIMIDAZOLEGLYCEROL-PHOSPHATE SYNTHASE, AMIDOTRANSFERASE; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (211 aa)
hisBIMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. (202 aa)
hisCPROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa)
hisDHISTIDINOL DEHYDROGENASE; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa)
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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