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Cgl0765 Cgl0765 rpsR rpsR rpsN rpsN rpmG rpmG rpmB rpmB rpmE rpmE rpmF rpmF Cgl0894 Cgl0894 rplY rplY recR recR Cgl0425 Cgl0425 rplK rplK rplA rplA rplJ rplJ rplL rplL rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO rpsM rpsM rpsK rpsK rpsD rpsD rplQ rplQ rplM rplM gyrB gyrB rpmH rpmH parA1 parA1 parB parB rpsF rpsF rplI rplI dnaB dnaB rpmJ rpmJ clpS clpS rplU rplU rpmA rpmA rpsT rpsT recO recO dnaG dnaG smc smc rpsI rpsI rpsP rpsP rimM rimM rplS rplS rpsB rpsB rpsO rpsO cg2132 cg2132 Cgl1843 Cgl1843 Cgl1633 Cgl1633 priA priA parA2 parA2 rplT rplT rpmI rpmI rpsA rpsA gyrA gyrA Cgl0033 Cgl0033 Cgl0243 Cgl0243
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cgl0765Uncharacterized ACR, COG2135; Belongs to the SOS response-associated peptidase family. (213 aa)
rpsR30S RIBOSOMAL PROTEIN S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (83 aa)
rpsN30S RIBOSOMAL PROTEIN S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpmG50S RIBOSOMAL PROTEIN L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
rpmB50S RIBOSOMAL PROTEIN L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpmEPROBABLE 50S RIBOSOMAL SUBUNIT PROTEIN L31. (88 aa)
rpmFRibosomal L32p protein family; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
Cgl0894PROBABLE ATP-DEPENDENT DNA HELICASE PROTEIN. (683 aa)
rplYRibosomal protein L25 (general stress protein Ctc); This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (200 aa)
recRDNA repair protein (RecF pathway); May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (218 aa)
Cgl0425Putative ribosomal protein L7/L12 family. (91 aa)
rplK50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (145 aa)
rplA50S RIBOSOMAL PROTEIN L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (236 aa)
rplJ50S RIBOSOMAL PROTEIN L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (171 aa)
rplLPROBABLE 50S RIBOSOMAL SUBUNIT PROTEIN L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (128 aa)
rpsLRIBOSOMAL PROTEIN S12; With S4 and S5 plays an important role in translational accuracy. (122 aa)
rpsG30S RIBOSOMAL PROTEIN S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (155 aa)
rpsJRIBOSOMAL PROTEIN S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (110 aa)
rplC50S RIBOSOMAL PROTEIN L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (218 aa)
rplD50S RIBOSOMAL PROTEIN L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (218 aa)
rplW50S RIBOSOMAL PROTEIN L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (101 aa)
rplB50S RIBOSOMAL PROTEIN L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (280 aa)
rpsS30S RIBOSOMAL PROTEIN S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplVRIBOSOMAL PROTEIN L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (120 aa)
rpsC30S RIBOSOMAL PROTEIN S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (248 aa)
rplP50S RIBOSOMAL PROTEIN L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa)
rpmC50S RIBOSOMAL PROTEIN L29; Belongs to the universal ribosomal protein uL29 family. (76 aa)
rpsQ30S RIBOSOMAL PROTEIN S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (92 aa)
rplN50S RIBOSOMAL PROTEIN L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplX50S RIBOSOMAL PROTEIN L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (104 aa)
rplE50S RIBOSOMAL PROTEIN L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (191 aa)
rpsHRIBOSOMAL PROTEIN S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rplF50S RIBOSOMAL PROTEIN L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rplR50S RIBOSOMAL PROTEIN L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (134 aa)
rpsE30S RIBOSOMAL PROTEIN S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (211 aa)
rpmD50S RIBOSOMAL PROTEIN L30. (61 aa)
rplORIBOSOMAL PROTEIN L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa)
rpsMRIBOSOMAL PROTEIN S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa)
rpsKRIBOSOMAL PROTEIN S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa)
rpsDRIBOSOMAL PROTEIN S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa)
rplQ50S RIBOSOMAL PROTEIN L17. (163 aa)
rplMRIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
gyrBDNA GYRASE SUBUNIT B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (684 aa)
rpmH50S RIBOSOMAL PROTEIN L34; Belongs to the bacterial ribosomal protein bL34 family. (47 aa)
parA1ATPases involved in chromosome partitioning. (307 aa)
parBPredicted transcriptional regulator involved in chromosome patitioning; Belongs to the ParB family. (379 aa)
rpsFRIBOSOMAL PROTEIN S6; Binds together with S18 to 16S ribosomal RNA. (95 aa)
rplI50S RIBOSOMAL PROTEIN L9; Binds to the 23S rRNA. (150 aa)
dnaBPUTATIVE REPLICATIVE DNA HELICASE; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (510 aa)
rpmJRibosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (40 aa)
clpSConserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (124 aa)
rplURIBOSOMAL PROTEIN L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (101 aa)
rpmA50S RIBOSOMAL PROTEIN L27; Belongs to the bacterial ribosomal protein bL27 family. (88 aa)
rpsT30S RIBOSOMAL PROTEIN S20; Binds directly to 16S ribosomal RNA. (87 aa)
recORecombinational DNA repair protein (RecF pathway); Involved in DNA repair and RecF pathway recombination. (242 aa)
dnaGDNA PRIMASE; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (633 aa)
smcChromosome segregation ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1155 aa)
rpsI30S RIBOSOMAL PROTEIN S9; Belongs to the universal ribosomal protein uS9 family. (182 aa)
rpsP30S RIBOSOMAL PROTEIN S16; Belongs to the bacterial ribosomal protein bS16 family. (165 aa)
rimMRIMM PROTEIN (16S RRNA PROCESSING PROTEIN); An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (171 aa)
rplS50S RIBOSOMAL PROTEIN L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (113 aa)
rpsB30S RIBOSOMAL PROTEIN S2; Belongs to the universal ribosomal protein uS2 family. (272 aa)
rpsORIBOSOMAL PROTEIN S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
cg2132Conserved hypothetical protein. (453 aa)
Cgl1843DNA TOPOISOMERASE I (OMEGA-PROTEIN). (759 aa)
Cgl1633Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase. (472 aa)
priAPrimosomal protein N' (replication factor Y)-superfamily II helicase; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (688 aa)
parA2PUTATIVE CHROMOSOME PARTITIONING ATPASE PROTEIN. (290 aa)
rplT50S RIBOSOMAL PROTEIN L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (127 aa)
rpmI50S RIBOSOMAL PROTEIN L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rpsA30S RIBOSOMAL PROTEIN S1. (486 aa)
gyrADNA TOPOISOMERASE (ATP-HYDROLYSING); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...] (856 aa)
Cgl0033Conserved hypothetical protein. (270 aa)
Cgl0243Uncharacterized BCR, YbaB family COG0718; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (103 aa)
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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