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| | rpsG | 30S RIBOSOMAL PROTEIN S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (155 aa) |
| | ndk | NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa) |
| | rplU | RIBOSOMAL PROTEIN L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (101 aa) |
| | rpmA | 50S RIBOSOMAL PROTEIN L27; Belongs to the bacterial ribosomal protein bL27 family. (88 aa) |
| | nadD | PUTATIVE NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (226 aa) |
| | Cgl2346 | Putative DNA polymerase III delta subunit. (331 aa) |
| | rpsT | 30S RIBOSOMAL PROTEIN S20; Binds directly to 16S ribosomal RNA. (87 aa) |
| | lepA | Membrane GTPase LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (615 aa) |
| | thiX | Secreted protein potentially involved into thiamin biosynthesis; Is necessary for biosynthesis of the 4-methyl-5-(beta- hydroxyethyl)thiazol component from which thiamine is formed. (190 aa) |
| | hemN | PUTATIVE ANAEROBIC COPROPORPHYRINOGEN III OXIDASE; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (380 aa) |
| | glyS | GLYCYL-TRNA SYNTHETASE (GLYCINE--TRNA LIGASE); Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (461 aa) |
| | dnaG | DNA PRIMASE; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (633 aa) |
| | cobS | PUTATIVE COBALAMIN (5'-PHOSPHATE) SYNTHASE; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (307 aa) |
| | cobT | PROBABLE NICOTINATE-NUCLEOTIDE-- DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE PROTEIN; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (358 aa) |
| | cobU | COBINAMIDE KINASE / COBINAMIDE PHOSPHATE GUANYLYLTRANSFERASE. (174 aa) |
| | ileS | ISOLEUCINE-TRNA LIGASE-LIKE PROTEIN; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1054 aa) |
| | dinP | Nucleotidyltransferase/DNA polymerase involved in DNA repair, DinP homolog; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (467 aa) |
| | dnaE1 | PUTATIVE DNA POLYMERASE III, ALPHA CHAIN. (1188 aa) |
| | Cgl2116 | DNA polymerase III epsilon subunit or related 3'-5' exonuclease. (476 aa) |
| | hisA | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. (246 aa) |
| | Cgl2091 | Putative indole-3-glycerol phosphate synthase. (261 aa) |
| | rpsP | 30S RIBOSOMAL PROTEIN S16; Belongs to the bacterial ribosomal protein bS16 family. (165 aa) |
| | thiG | THIAMIN BIOSYNTHESIS PROTEIN; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (260 aa) |
| | thiO | PUTATIVE D-AMINO ACID OXIDASE FLAVOPROTEIN OXIDOREDUCTASE. (374 aa) |
| | thiE | THIAMIN-PHOSPHATE PYROPHOSPHORYLASE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (221 aa) |
| | rplS | 50S RIBOSOMAL PROTEIN L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (113 aa) |
| | rpsB | 30S RIBOSOMAL PROTEIN S2; Belongs to the universal ribosomal protein uS2 family. (272 aa) |
| | tsf | TRANSLATION ELONGATION FACTOR TS (EF-TS); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (275 aa) |
| | pyrH | UMP-KINASE; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa) |
| | frr | RIBOSOME RECYCLING FACTOR; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | cobA | UROPORPHYRINOGEN III SYNTHASE/METHYLTRANSFERASE; Belongs to the precorrin methyltransferase family. (250 aa) |
| | proS | PROBABLE PROLYL-TRNA SYNTHETASE PROTEIN; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing [...] (588 aa) |
| | nusA | PUTATIVE TRANSCRIPTIONAL TERMINATION/ANTITERMINATION FACTOR; Participates in both transcription termination and antitermination. (332 aa) |
| | infB | Translation initiation factor 2 (GTPase); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (1004 aa) |
| | pptA | PHOSPHOPANTHETEINYL TRANSFERASE, IRON-CHELATING COMPLEX SUBUNIT; Belongs to the P-Pant transferase superfamily. (217 aa) |
| | ribF | PUTATIVE RIBOFLAVIN KINASE; Belongs to the ribF family. (341 aa) |
| | rpsO | RIBOSOMAL PROTEIN S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | thyX | Similar to thymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa) |
| | sigB | RNA POLYMERASE SIGMA FACTOR; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (331 aa) |
| | sigA | RNA POLYMERASE SIGMA 70 FACTOR; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (494 aa) |
| | dut | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa) |
| | dxs | PROBABLE 1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE PROTEIN; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (636 aa) |
| | ribD | RIBOFLAVIN SPECIFIC DEAMINASE. (232 aa) |
| | Cgl1775 | Hypothetical protein predicted by Glimmer/Critica. (2169 aa) |
| | thrS | THREONYL-TRNA SYNTHETASE; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (700 aa) |
| | apt | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa) |
| | rel | PPGPP SYNTHETASE, PPGPP PYROPHOSPHORYLASE; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. It also has (p)ppGpp-degrading activities. (760 aa) |
| | hisS | HISTIDYL-TRNA SYNTHETASE. (429 aa) |
| | aspS | PROBABLE ASPARTYL-TRNA SYNTHETASE PROTEIN; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (608 aa) |
| | alaS | ALANYL-TRNA SYNTHETASE; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (888 aa) |
| | efp | Translation elongation factor P/translation initiation factor eIF-5A; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity). (187 aa) |
| | nusB | Transcription termination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (227 aa) |
| | pyrB | ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa) |
| | pyrC | PUTATIVE DIHYDROOROTASE; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (447 aa) |
| | carA | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. (393 aa) |
| | carB | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. (1113 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa) |
| | gmk | PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP. (190 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit K/omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (95 aa) |
| | dfp | DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (391 aa) |
| | priA | Primosomal protein N' (replication factor Y)-superfamily II helicase; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (688 aa) |
| | def2 | POLYPEPTIDE DEFORMYLASE; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (169 aa) |
| | fmt | METHIONYL-TRNA FORMYLTRANSFERASE; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (315 aa) |
| | ribG | PUTATIVE BIFUNCTIONAL RIBOFLAVIN-SPECIFIC DEAMINASE/REDUCTASE; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (328 aa) |
| | ribA | PUTATIVE GTP CYCLOHYDROLASE II/3,4-DIHYDROXY-2-BUTANONE-4-PHOSPHATESYNTHASE; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. (422 aa) |
| | ribH | RIBOFLAVIN SYNTHASE, BETA CHAIN; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (159 aa) |
| | ctaB | Polyprenyltransferase (cytochrome oxidase assembly factor); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (323 aa) |
| | ctaA | Cytochrome oxidase assembly protein. (346 aa) |
| | Cgl1542 | Glutamine amidotransferase domain. (252 aa) |
| | hemH | FERROCHELATASE PRECURSOR; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (370 aa) |
| | pyrD | DIHYDROOROTATE DEHYDROGENASE; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (371 aa) |
| | cobL | PRECORRIN-6Y C5,15-METHYLTRANSFERASE (DECARBOXYLATING). (442 aa) |
| | thiM | HYDROXYETHYLTHIAZOLE KINASE; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (268 aa) |
| | thiD1 | PHOSPHOMETHYLPYRIMIDINE KINASE / HYDROXYMETHYLPYRI; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). In the N-terminal section; belongs to the thiamine- phosphate synthase family. In the C-terminal section; belongs to the thiaminase-2 family. (763 aa) |
| | cmk | CYTIDINE MONOPHOSPHATE (CMP) KINASE. (236 aa) |
| | pyrG | CTP SYNTHETASE; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (554 aa) |
| | Cgl1415 | CONSERVED MEMBRANE PROTEIN. (397 aa) |
| | ppnK | POLY(P)/ATP-NAD KINASE; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (320 aa) |
| | tyrS | TYROSYL-TRNA SYNTHETASE; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (420 aa) |
| | pheT | PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (835 aa) |
| | pheS | PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (345 aa) |
| | rplT | 50S RIBOSOMAL PROTEIN L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (127 aa) |
| | rpmI | 50S RIBOSOMAL PROTEIN L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa) |
| | infC | TRANSLATION INITIATION FACTOR IF3 PROTEIN; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (189 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | polA | DNA POLYMERASE I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (880 aa) |
| | coaD | PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | thiL | THIAMINE-MONOPHOSPHATE KINASE; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (305 aa) |
| | thiC | THIAMINE BIOSYNTHESIS PROTEIN; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (587 aa) |
| | gltS | PUTATIVE GLUTAMYL-TRNA SYNTHETASE; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (496 aa) |
| | gatB | PROBABLE GLU-TRNAGLN AMIDOTRANSFERASE SUBUNIT B PR; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (501 aa) |
| | gatA | PROBABLE GLU-TRNA (GLN) AMIDOTRANSFERASE (SUBUNIT A); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (497 aa) |
| | gatC | GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT C); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (99 aa) |
| | atpC | PROBABLE ATP SYNTHASE EPSILON CHAIN PROTEIN; Produces ATP from ADP in the presence of a proton gradient across the membrane. (124 aa) |
| | atpD | ATP SYNTHASE ALPHA SUBUNIT; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (483 aa) |
| | atpG | ATP SYNTHASE GAMMA SUBUNIT; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (325 aa) |
| | atpA | PROBABLE ATP SYNTHASE ALPHA CHAIN PROTEIN; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (547 aa) |
| | atpH | H+-ATPASE DELTA SUBUNIT; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (271 aa) |
| | atpF | ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (188 aa) |
| | atpE | ATP SYNTHASE C CHAIN; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (80 aa) |
| | atpB | ATP SYNTHASE F0 SUBUNIT 6; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (322 aa) |
| | prfA | PEPTIDE CHAIN RELEASE FACTOR 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (358 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (762 aa) |
| | argS | ARGINYL-TRNA SYNTHETASE; Belongs to the class-I aminoacyl-tRNA synthetase family. (550 aa) |
| | sigE | PUTATIVE RNA POLYMERASE SIGMA FACTOR, ECF family; Belongs to the sigma-70 factor family. ECF subfamily. (216 aa) |
| | folP2 | DIHYDROPTEROATE SYNTHASE; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (283 aa) |
| | Cgl1089 | SIMILAR TO KETOPANTOATE REDUCTASE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (300 aa) |
| | nadA | QUINOLINATE SYNTHETASE; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (428 aa) |
| | nadC | PUTATIVE NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE; Belongs to the NadC/ModD family. (279 aa) |
| | pabAB | PARA-AMINOBENZOATE SYNTHASE COMPONENT I and II. (620 aa) |
| | coaA | PANTOTHENATE KINASE. (323 aa) |
| | greA | Transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (174 aa) |
| | Cgl0980 | Pyrimidine reductase, riboflavin biosynthesis. (110 aa) |
| | ggtB | PROBABLE GAMMA-GLUTAMYLTRANSPEPTIDASE PRECURSOR PR. (567 aa) |
| | glmU | PUTATIVE UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (485 aa) |
| | prsA | PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE ISOZYME 2 PR; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa) |
| | rplY | Ribosomal protein L25 (general stress protein Ctc); This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (200 aa) |
| | pth1 | PROBABLE PEPTIDYL-TRNA HYDROLASE PROTEIN; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (177 aa) |
| | pth2 | PEPTIDYL-TRNA HYDROLASE; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (201 aa) |
| | prfC | PUTATIVE PEPTIDE CHAIN RELEASE FACTOR 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (582 aa) |
| | pdxK | PYRIDOXAL/PYRIDOXINE/PYRIDOXAMINE KINASE; Belongs to the pyridoxine kinase family. (264 aa) |
| | metS | METHIONYL-TRNA SYNTHETASE; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (610 aa) |
| | rpmF | Ribosomal L32p protein family; Belongs to the bacterial ribosomal protein bL32 family. (57 aa) |
| | rpmE | PROBABLE 50S RIBOSOMAL SUBUNIT PROTEIN L31. (88 aa) |
| | rpmB | 50S RIBOSOMAL PROTEIN L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa) |
| | rpmG | 50S RIBOSOMAL PROTEIN L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa) |
| | rpsN | 30S RIBOSOMAL PROTEIN S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rpsR | 30S RIBOSOMAL PROTEIN S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (83 aa) |
| | purH | 5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE-4- CARBOXYLASE. (520 aa) |
| | purN | 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (210 aa) |
| | thyA | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (266 aa) |
| | folA | DIHYDROFOLATE REDUCTASE. (152 aa) |
| | smpB | SMALL PROTEIN B HOMOLOGUE; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switch [...] (164 aa) |
| | prfB | PEPTIDE CHAIN RELEASE FACTOR 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (368 aa) |
| | pdxT | Glutamine amidotransferase involved in pyridoxine biosynthesis; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (200 aa) |
| | pdxS | Pyridoxine biosynthesis enzyme; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. (299 aa) |
| | sigH | PUTATIVE RNA POLYMERASE SIGMA FACTOR, ECF family; Belongs to the sigma-70 factor family. ECF subfamily. (206 aa) |
| | tmk | THYMIDYLATE KINASE, PUTATIVE; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (203 aa) |
| | manA | MANNOSE-6-PHOSPHATE ISOMERASE. (394 aa) |
| | rmlA2 | GDP-MANNOSE PYROPHOSPHORYLASE. (362 aa) |
| | Cgl0721 | Putative dihydrofolate reductase. (189 aa) |
| | purE | PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | purK | PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (399 aa) |
| | upp | PUTATIVE URACIL PHOSPHORIBOSYLTRANSFERASE; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa) |
| | trpS | TRYPTOPHAN TRNA SYNTHETASE; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (345 aa) |
| | folD | METHYLENETETRAHYDROFOLATE DEHYDROGENASE; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | dnaE2 | PUTATIVE DNA POLYMERASE III ALPHA CHAIN; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1055 aa) |
| | guaA | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. (523 aa) |
| | guaB3 | IMP dehydrogenase / GMP reductase C terminus. (374 aa) |
| | guaB2 | INOSITOL-MONOPHOSPHATE DEHYDROGENASE; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (506 aa) |
| | sigD | PUTATIVE RNA POLYMERASE SIGMA FACTOR, ECF family; Belongs to the sigma-70 factor family. ECF subfamily. (188 aa) |
| | rpsI | 30S RIBOSOMAL PROTEIN S9; Belongs to the universal ribosomal protein uS9 family. (182 aa) |
| | rplM | RIBOSOMAL PROTEIN L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa) |
| | rplQ | 50S RIBOSOMAL PROTEIN L17. (163 aa) |
| | rpoA | DNA-DIRECTED RNA POLYMERASE ALPHA SUBUNIT; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (338 aa) |
| | rpsD | RIBOSOMAL PROTEIN S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa) |
| | rpsK | RIBOSOMAL PROTEIN S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa) |
| | rpsM | RIBOSOMAL PROTEIN S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa) |
| | infA | TRANSLATION INITIATION FACTOR IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | adk | ADENYLATE KINASE; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (181 aa) |
| | rplO | RIBOSOMAL PROTEIN L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa) |
| | rpmD | 50S RIBOSOMAL PROTEIN L30. (61 aa) |
| | rpsE | 30S RIBOSOMAL PROTEIN S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (211 aa) |
| | rplR | 50S RIBOSOMAL PROTEIN L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (134 aa) |
| | rplF | 50S RIBOSOMAL PROTEIN L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa) |
| | rpsH | RIBOSOMAL PROTEIN S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rplE | 50S RIBOSOMAL PROTEIN L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (191 aa) |
| | rplX | 50S RIBOSOMAL PROTEIN L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (104 aa) |
| | rplN | 50S RIBOSOMAL PROTEIN L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rpsQ | 30S RIBOSOMAL PROTEIN S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (92 aa) |
| | rpmC | 50S RIBOSOMAL PROTEIN L29; Belongs to the universal ribosomal protein uL29 family. (76 aa) |
| | rplP | 50S RIBOSOMAL PROTEIN L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa) |
| | rpsC | 30S RIBOSOMAL PROTEIN S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (248 aa) |
| | rplV | RIBOSOMAL PROTEIN L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (120 aa) |
| | rpsS | 30S RIBOSOMAL PROTEIN S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa) |
| | rplB | 50S RIBOSOMAL PROTEIN L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (280 aa) |
| | rplW | 50S RIBOSOMAL PROTEIN L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (101 aa) |
| | rplD | 50S RIBOSOMAL PROTEIN L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (218 aa) |
| | rplC | 50S RIBOSOMAL PROTEIN L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (218 aa) |
| | rpsJ | RIBOSOMAL PROTEIN S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (110 aa) |
| | tuf | ELONGATION FACTOR TU; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa) |
| | fusA | ELONGATION FACTOR G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (709 aa) |
| | valS | PUTATIVE VALINE-TRNA LIGASE; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (903 aa) |
| | Cgl2454 | ABC-type transport system, ATPase component. (556 aa) |
| | Cgl2468 | Zn-dependent alcohol dehydrogenases, class III. (292 aa) |
| | Cgl2517 | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (446 aa) |
| | nrdF | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 BETA CHAIN; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (334 aa) |
| | rpmJ | Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (40 aa) |
| | nadE | NAD-SYNTHETASE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (277 aa) |
| | murA2 | UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa) |
| | pduO | ADENOSYLCOBALAMIN-DEPENDENT DIOL DEHYDRATASE GAMMA; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa) |
| | purM | PHOSPHORIBOSYL AMINOIMIDAZOLE SYNTHETASE. (358 aa) |
| | purF | AMIDOPHOSPHORIBOSYLTRANSFERASE; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (494 aa) |
| | purL | PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (762 aa) |
| | purQ | PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (223 aa) |
| | purS | PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE COMPONENT; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (81 aa) |
| | purC | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE; Belongs to the SAICAR synthetase family. (297 aa) |
| | purB | ADENYLOSUCCINATE LYASE; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | purD | PHOSPHORIBOSYLAMINE-GLYCINE LIGASE. (421 aa) |
| | bioA | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (423 aa) |
| | bioD | DETHIOBIOTIN SYNTHETASE PROTEIN; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (224 aa) |
| | cysS | CYSTEINE TRNA SYNTHETASE; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa) |
| | guaB1 | INOSITOL-MONOPHOSPHATE DEHYDROGENASE. (477 aa) |
| | lysS | LYSYL-TRNA SYNTHETASE; Belongs to the class-II aminoacyl-tRNA synthetase family. (526 aa) |
| | panC2 | SIMILAR TO PANTOTHENATE SYNTHETASE. (266 aa) |
| | folK | 7, 8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE. (159 aa) |
| | folX | DIHYDRONEOPTERIN ALDOLASE; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (130 aa) |
| | folP1 | DIHYDROPTEROATE SYNTHASE; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (284 aa) |
| | folE | GTP CYCLOHYDROLASE. (201 aa) |
| | hpt | HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (200 aa) |
| | speE | PUTATIVE SPERMIDINE SYNTHASE TRANSMEMBRANE PROTEIN; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (513 aa) |
| | def1 | POLYPEPTIDE DEFORMYLASE; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (193 aa) |
| | ackA | ACETATE KINASE; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. (397 aa) |
| | pta | PHOSPHATE ACETYLTRANSFERASE; Belongs to the phosphate acetyltransferase and butyryltransferase family. (461 aa) |
| | Cgl2755 | Acyltransferase. (182 aa) |
| | purT | PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (408 aa) |
| | purA | ADENYLOSUCCINATE SYNTHETASE; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | pyrE | OROTATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (184 aa) |
| | udgA2 | UDP-GLUCOSE 6-DEHYDROGENASE. (439 aa) |
| | dcd | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (189 aa) |
| | serS | SERYL-TRNA SYNTHETASE; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (432 aa) |
| | dnaB | PUTATIVE REPLICATIVE DNA HELICASE; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (510 aa) |
| | rplI | 50S RIBOSOMAL PROTEIN L9; Binds to the 23S rRNA. (150 aa) |
| | rpsF | RIBOSOMAL PROTEIN S6; Binds together with S18 to 16S ribosomal RNA. (95 aa) |
| | leuS | LEUCYL-TRNA SYNTHETASE; Belongs to the class-I aminoacyl-tRNA synthetase family. (964 aa) |
| | trpE | ANTHRANILATE SYNTHASE COMPONENT I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (518 aa) |
| | trpG | ANTHRANILATE SYNTHASE COMPONENT II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (208 aa) |
| | trpD | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | trpCF | INDOLE-3-GGLYCEROL-PHOSPHATE SYNTHASE/PHOSPHORIBOSYLANTHRANILATE ISOMERASE; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). (474 aa) |
| | trpB | TRYPTOPHAN SYNTHASE BETA CHAIN; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa) |
| | trpA | TRYPTOPHAN SYNTHASE ALPHA CHAIN; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (280 aa) |
| | thiD2 | PUTATIVE PHOSPHOMETHYLPYRIMIDINE KINASE (C-terminal fragment). (156 aa) |
| | thiD2-2 | PUTATIVE PHOSPHOMETHYLPYRIMIDINE KINASE. (266 aa) |
| | sigM | RNA POLYMERASE SIGMA-70 FACTOR, ECF SUBFAMILY. (201 aa) |
| | rpmH | 50S RIBOSOMAL PROTEIN L34; Belongs to the bacterial ribosomal protein bL34 family. (47 aa) |
| | folC | FOLYLPOLYGLUTAMATE SYNTHASE; Belongs to the folylpolyglutamate synthase family. (507 aa) |
| | dnaN | DNA POLYMERASE III, BETA SUBUNIT; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (394 aa) |
| | bioB | BIOTIN SYNTHASE; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (334 aa) |
| | amn | AMP NUCLEOSIDASE; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (477 aa) |
| | panC | PANTOATE--BETA-ALANINE LIGASE PROTEIN; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa) |
| | panB | 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa) |
| | panD | ASPARTATE 1-DECARBOXYLASE; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (136 aa) |
| | tgt | PUTATIVE TRNA-GUANINE TRANSGLYCOSYLASE; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to [...] (421 aa) |
| | Cgl0233 | CONSERVED HYPOTHETICAL membrane PROTEIN; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (250 aa) |
| | gltX | GLUTAMYL-TRNA SYNTHETASE-RELATED PROTEIN; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (293 aa) |
| | dnaZX | DNA POLYMERASE III GAMMA AND TAU SUBUNITS; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (775 aa) |
| | cobQ | COBYRIC ACID SYNTHASE. (250 aa) |
| | sigC | Sigma-70 factor (ECF subfamily). (193 aa) |
| | cyaB | Putative ADENYLATE CYCLASE. (547 aa) |
| | dnaX | PUTATIVE DNA POLYMERASE III, DELTA' SUBUNIT. (419 aa) |
| | rmlCD | DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE, dtdp-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (453 aa) |
| | murA | UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE. (438 aa) |
| | udgA1 | UDP-GLUCOSE 6-DEHYDROGENASE; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (387 aa) |
| | Cgl0368 | PUTATIVE TRANSCRIPTIONAL REGULATORY PROTEIN; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (173 aa) |
| | purU | PROBABLE FORMYLTETRAHYDROFOLATE DEFORMYLASE PROTEIN; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (304 aa) |
| | hemA | GLUTAMYL-TRNA REDUCTASE; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (463 aa) |
| | hemC | PORPHOBILINOGEN DEAMINASE; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (302 aa) |
| | Cgl0425 | Putative ribosomal protein L7/L12 family. (91 aa) |
| | hemD | UROPORPHYRINOGEN III SYNTHASE/METHYLTRANSFERASE. (598 aa) |
| | hemB | DELTA-AMINOLEVULINIC ACID DEHYDRATASE; Belongs to the ALAD family. (339 aa) |
| | hemE | UROPORPHYRINOGEN DECARBOXYLASE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (358 aa) |
| | hemY | PUTATIVE PROTOPORPHYRINOGEN OXIDASE; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (448 aa) |
| | hemL | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE. (437 aa) |
| | Cgl0465 | PUTATIVE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE. (93 aa) |
| | nusG | TRANSCRIPTION ANTITERMINATION PROTEIN NUSG; Participates in transcription elongation, termination and antitermination. (318 aa) |
| | rplK | 50S RIBOSOMAL PROTEIN L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (145 aa) |
| | rplA | 50S RIBOSOMAL PROTEIN L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (236 aa) |
| | rplJ | 50S RIBOSOMAL PROTEIN L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (171 aa) |
| | rplL | PROBABLE 50S RIBOSOMAL SUBUNIT PROTEIN L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (128 aa) |
| | rpoB | DNA-DIRECTED RNA POLYMERASE BETA CHAIN; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1165 aa) |
| | rpoC | DNA-DIRECTED RNA POLYMERASE BETA' CHAIN; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1333 aa) |
| | rpsL | RIBOSOMAL PROTEIN S12; With S4 and S5 plays an important role in translational accuracy. (122 aa) |
