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glnA glnA cysK cysK phoU phoU aroF aroF pyc pyc folD folD guaA guaA guaB2 guaB2 aroE aroE glxR glxR asd asd pknG pknG purA purA purQ purQ trpA trpA pheA pheA pstB pstB pstA pstA pstS pstS Cgl2587 Cgl2587 proB proB proA proA glnE glnE thrC thrC ilvA ilvA gdh gdh glnD glnD rel rel aroE3 aroE3 pyrB pyrB pyrF pyrF purB purB ribA ribA odhI odhI ssuA ssuA hom hom aroE2 aroE2 odhA odhA glyA glyA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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glnAGLUTAMINE SYNTHETASE I. (477 aa)
cysKO-Acetylserine (Thiol)-Lyase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
phoUPutative phosphate uptake regulator; Plays a role in the regulation of phosphate uptake. (244 aa)
aroFPROBABLE PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (366 aa)
pycPYRUVATE CARBOXYLASE; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1140 aa)
folDMETHYLENETETRAHYDROFOLATE DEHYDROGENASE; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
guaAPUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. (523 aa)
guaB2INOSITOL-MONOPHOSPHATE DEHYDROGENASE; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (506 aa)
aroEPUTATIVE SHIKIMATE 5-DEHYDROGENASE PROTEIN; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids, and plays a key role in the quinate degradation pathway. Catalyzes the NAD(+)-dependent oxidation of both quinate and shikimate to 3-dehydroquinate and 3- dehydroshikimate, respectively. It can only use NAD. (283 aa)
glxRTRANSCRIPTIONAL REGULATOR, CRP/FNR FAMILY; Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Involved in the regulation of gntP and gntK genes, which are involved in gluconate metabolism. May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes. It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole [...] (227 aa)
asdASPARTATE-SEMIALDEHYDE DEHYDROGENASE; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
pknGSerine/threonine protein kinase. (822 aa)
purAADENYLOSUCCINATE SYNTHETASE; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
purQPHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (223 aa)
trpATRYPTOPHAN SYNTHASE ALPHA CHAIN; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (280 aa)
pheAPREPHENATE DEHYDRATASE. (315 aa)
pstBABC-type phosphate transport system, ATPase component; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (257 aa)
pstAABC-type phosphate transport system, permease component. (307 aa)
pstSABC-type phosphate transport system, secreted component; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (375 aa)
Cgl2587Membrane protein, hemolysin III homolog. (254 aa)
proBGLUTAMATE 5-KINASE PROTEIN; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (409 aa)
proAGAMMA-GLUTAMYL PHOSPHATE REDUCTASE; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (432 aa)
glnEGLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (1045 aa)
thrCTHREONINE SYNTHASE; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (481 aa)
ilvATHREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). (436 aa)
gdhNADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. (447 aa)
glnDPROBABLE PROTEIN-PII URIDYLYLTRANSFERASE; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism (By simil [...] (692 aa)
relPPGPP SYNTHETASE, PPGPP PYROPHOSPHORYLASE; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. It also has (p)ppGpp-degrading activities. (760 aa)
aroE3PROBABLE SHIKIMATE 5-DEHYDROGENASE PROTEIN. (276 aa)
pyrBASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa)
purBADENYLOSUCCINATE LYASE; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
ribAPUTATIVE GTP CYCLOHYDROLASE II/3,4-DIHYDROXY-2-BUTANONE-4-PHOSPHATESYNTHASE; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. (422 aa)
odhIPUTATIVE SIGNAL TRANSDUCTION PROTEIN, FHA DOMAIN; An essential component of the PknG signaling pathway. When unphosphorylated, it inhibits the activity of 2-oxoglutarate dehydrogenase. When phosphorylated it does not inhibit 2-oxoglutarate dehydrogenase. (143 aa)
ssuAALIPHATIC SULFONATE BINDING PROTEIN. (319 aa)
homHomoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. (445 aa)
aroE2PUTATIVE SHIKIMATE / QUINATE 5-DEHYDROGENASE. (268 aa)
odhA2-OXOGLUTARATE DEHYDROGENASE; Catalyzes the E1 and E2 reactions as part of 2-oxoglutarate dehydrogenase (ODH) activity, to convert 2-oxoglutarate to succinyl-CoA and CO(2). OdhA has reductase activity with 2-oxoglutarate but does not react with pyruvate, and also displays transsuccinylase but no transacetylase activity. Since OdhA is not lipoylated, the succinyltransferase activity of its E2 domain is dependent on lipoyl residues of the acetyltransferase AceF. (1257 aa)
glyASerine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa)
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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