STRINGSTRING
serA serA Cgl1058 Cgl1058 glyA glyA eno eno Cgl0299 Cgl0299 lpd lpd Cgl0415 Cgl0415 Cgl0438 Cgl0438 prpC2 prpC2 lysC lysC lpdA lpdA prpC1 prpC1 serC serC gltA gltA pgi pgi Cgl2898 Cgl2898 Cgl2796 Cgl2796 sucD sucD serB serB Cgl2355 Cgl2355 thrC thrC thrS thrS sdaA sdaA pgk pgk tal tal
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
serAPhosphoglycerate Dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
Cgl1058Similarity to 2,3-PDG dependent phosphoglycerate mutase pgm-Amycolatopsis methanolica. (233 aa)
glyASerine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa)
enoENOLASE (2-PHOSPHOGLYCERATE DEHYDRATASE; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
Cgl0299Putative phosphatase. (280 aa)
lpdDIHYDROLIPOAMIDE DEHYDROGENASE; Lipoamide dehydrogenase is an essential component of the pyruvate dehydrogenase (PDH) and 2-oxoglutarate dehydrogenase (ODH) complexes. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes. Also catalyzes a reversible NADH:NAD(+) transhydrogenation, and is able to transfer electrons from NADH to various redox-active compounds and quinones. May be involved in quinone redox cycling in C.glutamicum. (469 aa)
Cgl0415Putative phosphatase. (355 aa)
Cgl0438PUTATIVE PHOSPHOGLYCERATE MUTASE. (202 aa)
prpC2METHYLCITRATE SYNTHASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity. (383 aa)
lysCASPARTOKINASE LYSC ALPHA and beta SUBUNITs; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family. (421 aa)
lpdADIHYDROLIPOAMIDE DEHYDROGENASE. (469 aa)
prpC1(METHYL)CITRATE SYNTHASE; Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with propionyl-CoA but with a lower specificity. (381 aa)
serCPhosphoserine Transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (376 aa)
gltACITRATE SYNTHASE. (437 aa)
pgiGLUCOSE-6-PHOSPHATE ISOMERASE. (540 aa)
Cgl2898PHOSPHOGLYCERATE MUTASE FAMILY PROTEIN; Belongs to the phosphoglycerate mutase family. (223 aa)
Cgl2796ALDEHYDE DEHYDROGENASE; Belongs to the aldehyde dehydrogenase family. (506 aa)
sucDSUCCINYL-COA SYNTHETASE ALPHA SUBUNIT; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
serBPhosphoserine Phosphatase. (446 aa)
Cgl2355Phosphoglycerate dehydrogenase or related dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (304 aa)
thrCTHREONINE SYNTHASE; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (481 aa)
thrSTHREONYL-TRNA SYNTHETASE; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (700 aa)
sdaAPROBABLE L-SERINE DEHYDRATASE (L-SERINE DEAMINASE); Belongs to the iron-sulfur dependent L-serine dehydratase family. (449 aa)
pgkPHOSPHOGLYCERATE KINASE; Belongs to the phosphoglycerate kinase family. (405 aa)
talTRANSALDOLASE; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (360 aa)
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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