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hisE hisE nanH nanH dtxR dtxR lexA lexA ftsK ftsK lysC lysC rpoB rpoB rpoC rpoC hisF hisF crtEb crtEb crtYf crtYf crtYe crtYe crtB2 crtB2 Cgl2587 Cgl2587 crtB crtB clpX clpX ftsI ftsI ftsW ftsW ftsQ ftsQ ftsZ ftsZ hisD hisD hisB hisB hisA hisA crtE crtE hom hom hisG hisG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisEPHOSPHORIBOSYL-ATP CYCLOHYDROLASE. (87 aa)
nanHSECRETED SIALIDASE. (399 aa)
dtxRIRON DEPENDENT REGULATORY PROTEIN-DTXR HOMOLOG; Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression (By similarity). Represses ripA under iron excess. (228 aa)
lexAPUTATIVE LEXA REPRESSOR TRANSCRIPTION REGULATOR PROTEIN; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (253 aa)
ftsKCELL DIVISION PROTEIN, REQUIRED FOR CELL DIVISION AND CHROMOSOMEPARTITIONING; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Belongs to the FtsK/SpoIIIE/SftA family. (1010 aa)
lysCASPARTOKINASE LYSC ALPHA and beta SUBUNITs; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family. (421 aa)
rpoBDNA-DIRECTED RNA POLYMERASE BETA CHAIN; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1165 aa)
rpoCDNA-DIRECTED RNA POLYMERASE BETA' CHAIN; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1333 aa)
hisFPROBABLE CYCLASE (IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE-SUBUNIT); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (258 aa)
crtEbLYCOPENE ELONGASE. (287 aa)
crtYfC50 CAROTENOID EPSILON CYCLASE. (130 aa)
crtYeC50 CAROTENOID EPSILON CYCLASE. (149 aa)
crtB2PHYTOENE SYNTHETASE. (304 aa)
Cgl2587Membrane protein, hemolysin III homolog. (254 aa)
crtBPHYTOENE SYNTHETASE. (287 aa)
clpXPROBABLE ATP-DEPENDENT PROTEASE (ATP-BINDING SPECIFICITY SUBUNIT); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
ftsIPENICILLIN-BINDING PROTEIN 2X. (651 aa)
ftsWBacterial cell division membrane protein; Belongs to the SEDS family. (550 aa)
ftsQCell division septal protein; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. (222 aa)
ftsZCell division GTPase; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (442 aa)
hisDHISTIDINOL DEHYDROGENASE; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa)
hisBIMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. (202 aa)
hisAPHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. (246 aa)
crtEGeranylgeranyl-pyrophosphate sythase; Belongs to the FPP/GGPP synthase family. (372 aa)
homHomoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. (445 aa)
hisGATP PHOSPHORIBOSYLTRANSFERASE; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa)
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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