STRINGSTRING
hemD hemD hemB hemB hemL hemL gabT gabT pyc pyc gltA gltA pta pta pgi pgi ackA ackA mdh mdh aceE aceE sucB sucB pyk pyk gdh gdh pgk pgk ppc ppc zwf zwf gltS gltS pck pck ldh ldh pfkA pfkA gltX gltX lpd lpd hemA hemA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hemDUROPORPHYRINOGEN III SYNTHASE/METHYLTRANSFERASE. (598 aa)
hemBDELTA-AMINOLEVULINIC ACID DEHYDRATASE; Belongs to the ALAD family. (339 aa)
hemLGLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE. (437 aa)
gabTPROBABLE 4-AMINOBUTYRATE AMINOTRANSFERASE PROTEIN; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa)
pycPYRUVATE CARBOXYLASE; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1140 aa)
gltACITRATE SYNTHASE. (437 aa)
ptaPHOSPHATE ACETYLTRANSFERASE; Belongs to the phosphate acetyltransferase and butyryltransferase family. (461 aa)
pgiGLUCOSE-6-PHOSPHATE ISOMERASE. (540 aa)
ackAACETATE KINASE; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. (397 aa)
mdhMALATE DEHYDROGENASE OXIDOREDUCTASE PROTEIN; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Almost equally active both for NADH and NADPH on the bases of the kcat values at pH 6.5, but catalytic efficiency for oxaloacetate reduction is 50-fold higher with NADH. (328 aa)
aceEPYRUVATE DEHYDROGENASE E1 COMPONENT; Is a specific component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl- CoA and CO(2). AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate. (922 aa)
sucBDIHYDROLIPOAMIDE SUCCINYLTRANSFERASE; Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF. Belongs to the 2-oxoacid dehydrogenase family. (675 aa)
pykPYRUVATE KINASE. (477 aa)
gdhNADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. (447 aa)
pgkPHOSPHOGLYCERATE KINASE; Belongs to the phosphoglycerate kinase family. (405 aa)
ppcPHOSPHOENOLPYRUVATE CARBOXYLASE; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (919 aa)
zwfGLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (514 aa)
gltSPUTATIVE GLUTAMYL-TRNA SYNTHETASE; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (496 aa)
pckPROBABLE PHOSPHOENOLPYRUVATE CARBOXYKINASE PROTEIN; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (610 aa)
ldhL-LACTATE DEHYDROGENASE; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (314 aa)
pfkA6-PHOSPHOFRUCTOKINASE; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (343 aa)
gltXGLUTAMYL-TRNA SYNTHETASE-RELATED PROTEIN; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (293 aa)
lpdDIHYDROLIPOAMIDE DEHYDROGENASE; Lipoamide dehydrogenase is an essential component of the pyruvate dehydrogenase (PDH) and 2-oxoglutarate dehydrogenase (ODH) complexes. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes. Also catalyzes a reversible NADH:NAD(+) transhydrogenation, and is able to transfer electrons from NADH to various redox-active compounds and quinones. May be involved in quinone redox cycling in C.glutamicum. (469 aa)
hemAGLUTAMYL-TRNA REDUCTASE; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (463 aa)
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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