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pyc pyc pgi pgi tdcB tdcB pfkA pfkA ilvD ilvD ilvB ilvB ilvN ilvN ilvC ilvC leuB leuB ptsG ptsG ppnK ppnK gnd gnd zwf zwf ppc ppc tpi tpi ppgK ppgK ptsI ptsI ptsH ptsH dapA dapA gdh gdh pyk pyk ilvA ilvA panC panC sucB sucB aceE aceE brnQ brnQ ramA ramA Cgl2647 Cgl2647 panC2 panC2 ackA ackA pta pta Cgl2796 Cgl2796 sod sod glk glk panB panB panD panD leuA leuA lrp lrp brnF brnF brnE brnE lpd lpd tuf tuf alr alr
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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pycPYRUVATE CARBOXYLASE; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1140 aa)
pgiGLUCOSE-6-PHOSPHATE ISOMERASE. (540 aa)
tdcBTHREONINE DEHYDRATASE. (310 aa)
pfkA6-PHOSPHOFRUCTOKINASE; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (343 aa)
ilvDDIHYDROXY-ACID DEHYDRATASE; Belongs to the IlvD/Edd family. (613 aa)
ilvBACETOLACTATE SYNTHASE. (626 aa)
ilvNACETOHYDROXYACID SYNTHASE SMALL SUBUNIT. (172 aa)
ilvCKETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
leuB3-ISOPROPYLMALATE DEHYDROGENASE; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (340 aa)
ptsGGLUCOSE-SPECIFIC ENZYME II BC COMPONENT OF PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport. (683 aa)
ppnKPOLY(P)/ATP-NAD KINASE; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (320 aa)
gnd6-PHOSPHOGLUCONATE DEHYDROGENASE; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (492 aa)
zwfGLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (514 aa)
ppcPHOSPHOENOLPYRUVATE CARBOXYLASE; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (919 aa)
tpiTRIOSEPHOSPHATE ISOMERASE; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (259 aa)
ppgKPOLYPHOSPHATE GLUCOKINASE. (250 aa)
ptsIPHOSPHOENOLPYRUVATE:SUGAR PHOSPHOTRANSFERASE SYSTEM ENZYMEI; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (568 aa)
ptsHPHOSPHOCARRIER PROTEIN HPR. (89 aa)
dapADIHYDRODIPICOLINATE SYNTHASE; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa)
gdhNADP-SPECIFIC GLUTAMATE DEHYDROGENASE; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. (447 aa)
pykPYRUVATE KINASE. (477 aa)
ilvATHREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). (436 aa)
panCPANTOATE--BETA-ALANINE LIGASE PROTEIN; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa)
sucBDIHYDROLIPOAMIDE SUCCINYLTRANSFERASE; Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF. Belongs to the 2-oxoacid dehydrogenase family. (675 aa)
aceEPYRUVATE DEHYDROGENASE E1 COMPONENT; Is a specific component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl- CoA and CO(2). AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate. (922 aa)
brnQBranched-Chain Amino Acid Uptake Carrier; Component of the transport system for branched-chain amino acids (leucine, isoleucine and valine) Which is coupled to a proton motive force. (426 aa)
ramABacterial regulatory protein, LuxR family; RamA is a master regulator of acetate metabolism. It positively controls the expression of acnA, aceA, aceB, ack, pta and ramB genes in the presence of acetate. RamA is also a positive regulator of rpf2 gene expression during growth on glucose as the sole carbon source. (281 aa)
Cgl2647Transcriptional regulator ROK family, putative sugar kinase. (303 aa)
panC2SIMILAR TO PANTOTHENATE SYNTHETASE. (266 aa)
ackAACETATE KINASE; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. (397 aa)
ptaPHOSPHATE ACETYLTRANSFERASE; Belongs to the phosphate acetyltransferase and butyryltransferase family. (461 aa)
Cgl2796ALDEHYDE DEHYDROGENASE; Belongs to the aldehyde dehydrogenase family. (506 aa)
sodMANGANESE SUPEROXIDE DISMUTASE; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (200 aa)
glkGLUCOKINASE, TRANSCRIPTIONAL REGULATOR. (323 aa)
panB3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa)
panDASPARTATE 1-DECARBOXYLASE; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (136 aa)
leuA2-ISOPROPYLMALATE SYNTHASE; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (616 aa)
lrpLeucine responsive regulator. (151 aa)
brnFBranched chain amino acid exporter, large subunit. (251 aa)
brnEBranched chain amino acid exporter, small subunit. (108 aa)
lpdDIHYDROLIPOAMIDE DEHYDROGENASE; Lipoamide dehydrogenase is an essential component of the pyruvate dehydrogenase (PDH) and 2-oxoglutarate dehydrogenase (ODH) complexes. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes. Also catalyzes a reversible NADH:NAD(+) transhydrogenation, and is able to transfer electrons from NADH to various redox-active compounds and quinones. May be involved in quinone redox cycling in C.glutamicum. (469 aa)
tufELONGATION FACTOR TU; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa)
alrALANINE RACEMASE; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. (361 aa)
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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