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OTG59330.1 OTG59330.1 OTG60845.1 OTG60845.1 OTG60846.1 OTG60846.1 OTG60847.1 OTG60847.1 mqo mqo eno eno OTG60915.1 OTG60915.1 OTG61006.1 OTG61006.1 OTG61007.1 OTG61007.1 OTG61014.1 OTG61014.1 OTG61015.1 OTG61015.1 OTG61016.1 OTG61016.1 OTG61017.1 OTG61017.1 dld dld OTG61125.1 OTG61125.1 OTG61157.1 OTG61157.1 OTG61278.1 OTG61278.1 OTG61279.1 OTG61279.1 OTG61335.1 OTG61335.1 sucD sucD sucC sucC OTG61379.1 OTG61379.1 OTG61380.1 OTG61380.1 OTG61567.1 OTG61567.1 sdhB sdhB OTG61382.1 OTG61382.1 OTG61383.1 OTG61383.1 OTG61384.1 OTG61384.1 OTG61385.1 OTG61385.1 OTG61394.1 OTG61394.1 OTG61425.1 OTG61425.1 nuoN nuoN OTG61457.1 OTG61457.1 OTG61458.1 OTG61458.1 nuoK nuoK OTG61460.1 OTG61460.1 nuoI nuoI nuoH nuoH OTG61463.1 OTG61463.1 OTG61464.1 OTG61464.1 OTG61465.1 OTG61465.1 nuoC nuoC nuoB nuoB nuoA nuoA OTG59896.1 OTG59896.1 OTG59908.1 OTG59908.1 OTG59916.1 OTG59916.1 OTG59980.1 OTG59980.1 OTG60015.1 OTG60015.1 OTG60242.1 OTG60242.1 OTG60243.1 OTG60243.1 OTG60275.1 OTG60275.1 OTG60350.1 OTG60350.1 mdh mdh OTG59226.1 OTG59226.1 OTG59359.1 OTG59359.1 OTG58538.1 OTG58538.1 OTG58542.1 OTG58542.1 fumC fumC OTG58783.1 OTG58783.1 OTG58784.1 OTG58784.1 OTG58911.1 OTG58911.1 OTG58122.1 OTG58122.1 ubiE ubiE OTG58155.1 OTG58155.1 tpiA tpiA gpmI gpmI OTG57860.1 OTG57860.1 OTG57861.1 OTG57861.1 OTG57862.1 OTG57862.1 OTG57908.1 OTG57908.1 OTG57926.1 OTG57926.1 OTG57451.1 OTG57451.1 pgk pgk OTG57474.1 OTG57474.1 glcB glcB OTG57554.1 OTG57554.1 OTG57587.1 OTG57587.1 OTG57599.1 OTG57599.1 rpiA rpiA OTG57099.1 OTG57099.1 OTG57102.1 OTG57102.1 OTG57103.1 OTG57103.1 azoR azoR OTG57126.1 OTG57126.1 dsbB dsbB OTG57206.1 OTG57206.1 ppc ppc OTG56905.1 OTG56905.1 OTG56407.1 OTG56407.1 OTG56417.1 OTG56417.1 OTG56430.1 OTG56430.1 OTG56447.1 OTG56447.1 pgi pgi OTG56003.1 OTG56003.1 OTG55289.1 OTG55289.1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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OTG59330.1FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
OTG60845.1Cytochrome d terminal oxidase subunit 1; Part of the aerobic respiratory chain; catalyzes the ubiquinol to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
OTG60846.1Cytochrome d ubiquinol oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
OTG60847.1Cytochrome bd-I oxidase subunit CydX; Derived by automated computational analysis using gene prediction method: Protein Homology. (33 aa)
mqoMalate dehydrogenase (quinone); Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa)
OTG60915.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (879 aa)
OTG61006.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
OTG61007.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
OTG61014.1Ubiquinol oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
OTG61015.1Cytochrome o ubiquinol oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the heme-copper respiratory oxidase family. (662 aa)
OTG61016.1Cytochrome o ubiquinol oxidase subunit III; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
OTG61017.1Cytochrome o ubiquinol oxidase subunit IV; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (564 aa)
OTG61125.1hydroxymethylglutaryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
OTG61157.1Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
OTG61278.1Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
OTG61279.1Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
OTG61335.1Isocitrate lyase; Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
OTG61379.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
OTG61380.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (404 aa)
OTG61567.12-oxoglutarate dehydrogenase E1 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (940 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
OTG61382.1Succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (632 aa)
OTG61383.1Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (121 aa)
OTG61384.1Succinate dehydrogenase, cytochrome b556 subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
OTG61385.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (424 aa)
OTG61394.1Flavodoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
OTG61425.1NADPH-dependent FMN reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
nuoNNADH-quinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (498 aa)
OTG61457.1NADH-quinone oxidoreductase subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa)
OTG61458.1NADH-quinone oxidoreductase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology. (629 aa)
nuoKNADH-quinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (102 aa)
OTG61460.1NADH-quinone oxidoreductase subunit J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (173 aa)
nuoINADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
nuoHNADH-quinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (335 aa)
OTG61463.1NADH-quinone oxidoreductase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (893 aa)
OTG61464.1NADH-quinone oxidoreductase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (443 aa)
OTG61465.1NADH-quinone oxidoreductase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
nuoCNADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. (595 aa)
nuoBNADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (225 aa)
nuoANADH-quinone oxidoreductase subunit A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (182 aa)
OTG59896.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa)
OTG59908.1Histidine phosphatase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
OTG59916.1Nitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (934 aa)
OTG59980.1Iron-sulfur protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (264 aa)
OTG60015.1Rubredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (54 aa)
OTG60242.1Cytochrome ubiquinol oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)
OTG60243.1Cytochrome d ubiquinol oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
OTG60275.1Malonate decarboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (551 aa)
OTG60350.1Fe/S-dependent 2-methylisocitrate dehydratase AcnD; Derived by automated computational analysis using gene prediction method: Protein Homology. (878 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
OTG59226.1NAD(P)H:quinone oxidoreductase, type IV; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the WrbA family. (197 aa)
OTG59359.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
OTG58538.1ISC system 2Fe-2S type ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
OTG58542.1Aspartate ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
OTG58783.1Cytochrome ubiquinol oxidase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
OTG58784.1Cytochrome d ubiquinol oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
OTG58911.1EF-P beta-lysylation protein EpmB; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
OTG58122.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (570 aa)
ubiEBifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (314 aa)
OTG58155.1Monovalent cation/H+ antiporter subunit D; Derived by automated computational analysis using gene prediction method: Protein Homology. (602 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa)
gpmIPhosphoglycerate mutase (2,3-diphosphoglycerate-independent); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (515 aa)
OTG57860.1NAD synthetase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (484 aa)
OTG57861.1NAD(P) transhydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
OTG57862.1NAD(P) transhydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
OTG57908.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (917 aa)
OTG57926.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa)
OTG57451.1Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (345 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (396 aa)
OTG57474.1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (328 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (720 aa)
OTG57554.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa)
OTG57587.1Isocitrate dehydrogenase (NADP(+)); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (743 aa)
OTG57599.12-methylcitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (378 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa)
OTG57099.1MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
OTG57102.1Pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa)
OTG57103.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
azoRFMN-dependent NADH-azoreductase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family. (188 aa)
OTG57126.1Thiol:disulfide interchange protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (608 aa)
dsbBDisulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (171 aa)
OTG57206.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (894 aa)
OTG56905.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
OTG56407.1Molybdopterin dinucleotide-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1328 aa)
OTG56417.1Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)
OTG56430.1Glycerol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
OTG56447.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (572 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (553 aa)
OTG56003.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
OTG55289.1NADH oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
Your Current Organism:
Acinetobacter sp. ANC4204
NCBI taxonomy Id: 1977884
Other names: A. sp. ANC 4204, Acinetobacter sp. ANC 4204
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