STRINGSTRING
dnaQ dnaQ gyrB-1 gyrB-1 ARO28055.1 ARO28055.1 ARO28056.1 ARO28056.1 recR recR dnaX dnaX recF recF polA polA recX recX dnaN dnaN dnaA dnaA mutS mutS ARO28575.1 ARO28575.1 yacG yacG ARO28750.1 ARO28750.1 mutL mutL rnhB rnhB rnhA-1 rnhA-1 ARO29298.1 ARO29298.1 recO recO radA radA dnaB dnaB ARO29538.1 ARO29538.1 uvrC uvrC parC parC dnaE1 dnaE1 dinB-1 dinB-1 topA topA ARO29928.1 ARO29928.1 recJ recJ ARO30018.1 ARO30018.1 lexA lexA recG recG uvrA uvrA ssb ssb gyrA gyrA holB holB gyrB-2 gyrB-2 recA recA rnhA-2 rnhA-2 uvrB uvrB ARO30859.1 ARO30859.1 uvrD uvrD ARO30920.1 ARO30920.1 ligA ligA recN recN recQ recQ dnaG dnaG ARO31288.1 ARO31288.1 priA priA dnaE2-1 dnaE2-1 imuB-1 imuB-1 ARO32260.1 ARO32260.1 ARO32292.1 ARO32292.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (240 aa)
gyrB-1DNA gyrase subunit B 1; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (811 aa)
ARO28055.1Double-strand break repair helicase AddA type protein; Protein involved in hydrolase activity and ATP binding; Belongs to the helicase family. UvrD subfamily. (1183 aa)
ARO28056.1Double-strand break repair helicase AddB type protein. (1064 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (621 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (374 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (999 aa)
recXDNA repair regulator protein RecX; Modulates RecA activity; Belongs to the RecX family. (183 aa)
dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
dnaAChromosomal replication initiation protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (516 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (908 aa)
ARO28575.1DNA helicase UvrD-like protein; Protein involved in hydrolase activity and ATP binding. (686 aa)
yacGDNA gyrase inhibitor YacG; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (70 aa)
ARO28750.1Conjugal transfer relaxase TraA-like protein; Protein involved in unidirectional conjugation. (1550 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (600 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (229 aa)
rnhA-1Ribonuclease H 1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (151 aa)
ARO29298.1Pentapeptide repeat-containing protein. (233 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (256 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (466 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (498 aa)
ARO29538.1DNA polymerase III chi subunit HolC protein; Protein involved in DNA binding, DNA-directed DNA polymerase activity and DNA replication. (149 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (679 aa)
parCDNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (751 aa)
dnaE1DNA polymerase III subunit alpha; Protein involved in catalytic activity, DNA-directed DNA polymerase activity and DNA replication. (1165 aa)
dinB-1DNA polymerase IV 1; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (430 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (884 aa)
ARO29928.1Protein involved in DNA primase activity, helicase activity, zinc ion binding and DNA replication. (539 aa)
recJProtein involved in 5'-3' exonuclease activity, manganese ion binding, DNA repair and DNA recombination. (600 aa)
ARO30018.1Hypothetical protein. (213 aa)
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (238 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (701 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (973 aa)
ssbSingle-stranded DNA-binding protein Ssb; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (168 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (935 aa)
holBDNA polymerase III delta' subunit. (340 aa)
gyrB-2DNA gyrase subunit B 2; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (690 aa)
recARecombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (362 aa)
rnhA-2Ribonuclease H 2; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (175 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (1002 aa)
ARO30859.1P-loop NTPase domain-containing protein. (375 aa)
uvrDDNA helicase II; Protein involved in hydrolase activity and ATP binding. (825 aa)
ARO30920.1Exonuclease RNase T/DNA polymerase III protein; Protein involved in nucleic acid binding. (196 aa)
ligADNA ligase (NAD(+)); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (718 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (557 aa)
recQProtein involved in ATP-dependent 3'-5' DNA helicase activity, ATP binding, ATP-dependent helicase activity, DNA replication and DNA repair. (622 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (665 aa)
ARO31288.1AAA ATPase domain-containing protein; Protein involved in ATP binding and nucleoside-triphosphatase activity. (221 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (738 aa)
dnaE2-1Error-prone DNA polymerase 1; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1151 aa)
imuB-1DNA-repair protein ImuB 1; Protein involved in damaged DNA binding, DNA-directed DNA polymerase activity and DNA repair. (472 aa)
ARO32260.1Inducible mutagenesis ImuA-like protein. (317 aa)
ARO32292.1Protein involved in DNA binding, DNA-directed DNA polymerase activity and DNA replication. (346 aa)
Your Current Organism:
Rhizobium sp. NXC14
NCBI taxonomy Id: 1981173
Other names: R. sp. NXC14
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