STRINGSTRING
hrpB hrpB ppiB ppiB cspE cspE rhlE rhlE rpsA rpsA rne rne rnb rnb rnd rnd hrpA hrpA ypfI ypfI deaD deaD pnp pnp ppiA ppiA yhgJ yhgJ rph rph rhlB rhlB vacB vacB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hrpBHelicase; Code: L; COG: COG1643. (824 aa)
ppiBPeptidyl-prolyl cis-trans isomerase B (rotamase B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
cspECold shock protein; Code: K; COG: COG1278. (69 aa)
rhlEPutative ATP-dependent RNA helicase; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (406 aa)
rpsA30S ribosomal subunit protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). (557 aa)
rneSimilar to Escherichia coli K12 flagellar biosynthesis; hook-filament junction protein gi: 1787324 (318 aa). BLAST with identity of 94% in 314 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. (1060 aa)
rnbExoribonuclease 2; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. (644 aa)
rndRNase D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. (371 aa)
hrpAHelicase; Code: L; COG: COG1643. (1281 aa)
ypfIConserved hypothetical protein; Code: R; COG: COG1444. (671 aa)
deaDInducible ATP-independent RNA helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (646 aa)
pnpPolynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (734 aa)
ppiAPeptidyl-prolyl cis-trans isomerase A (rotamase A); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (193 aa)
yhgJRNA 3'-terminal phosphate cyclase (ATP); Similar to Escherichia coli K12 positive regulator of mal regulon gi: 2367223 (902 aa). BLAST with identity of 99% in 894 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. (201 aa)
rphRNase PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
rhlBPutative ATP-dependent RNA helicase; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (421 aa)
vacBPutative enzyme; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity). Required for the expression of virulence genes on the large plasmid of S.flexneri at the post-transcriptional level. Belongs to the RNR ribonuclease family. RNase R subfamily. (827 aa)
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.