11 items (Shigella flexneri) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	trxB	Thioredoxin reductase; Code: O; COG: COG0492. (321 aa)
	selD	Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (347 aa)
	malY	Cystathionine beta-lyase; Code: E; COG: COG1168. (390 aa)
	metG	Methionine tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (677 aa)
	cysN	ATP-sulfurylase (ATP:sulfate adenylyltransferase), subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (475 aa)
	cysD	ATP-sulfurylase (ATP:sulfate adenylyltransferase), subunit 2; Code: EH; COG: COG0175. (302 aa)
	metC	Cystathionine beta-lyase (beta-cystathionase); Code: E; COG: COG0626. (395 aa)
	selA	Selenocysteine synthase: L-seryl-tRNA (Ser) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (463 aa)
	metE	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
	metB	Cystathionine gamma-synthase; Code: E; COG: COG0626. (386 aa)
	metH	B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Code: E; COG: COG1410. (1227 aa)

Your Current Organism:

Shigella flexneri

NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cysD	cysN	SF2775	SF2774	ATP-sulfurylase (ATP:sulfate adenylyltransferase), subunit 2; Code: EH; COG: COG0175.	ATP-sulfurylase (ATP:sulfate adenylyltransferase), subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.	0.999
cysN	cysD	SF2774	SF2775	ATP-sulfurylase (ATP:sulfate adenylyltransferase), subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.	ATP-sulfurylase (ATP:sulfate adenylyltransferase), subunit 2; Code: EH; COG: COG0175.	0.999
malY	metB	SF1647	SF4017	Cystathionine beta-lyase; Code: E; COG: COG1168.	Cystathionine gamma-synthase; Code: E; COG: COG0626.	0.949
malY	metC	SF1647	SF3053	Cystathionine beta-lyase; Code: E; COG: COG1168.	Cystathionine beta-lyase (beta-cystathionase); Code: E; COG: COG0626.	0.934
malY	metE	SF1647	SF3907	Cystathionine beta-lyase; Code: E; COG: COG1168.	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.901
malY	metH	SF1647	SF4085	Cystathionine beta-lyase; Code: E; COG: COG1168.	B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Code: E; COG: COG1410.	0.930
metB	malY	SF4017	SF1647	Cystathionine gamma-synthase; Code: E; COG: COG0626.	Cystathionine beta-lyase; Code: E; COG: COG1168.	0.949
metB	metC	SF4017	SF3053	Cystathionine gamma-synthase; Code: E; COG: COG0626.	Cystathionine beta-lyase (beta-cystathionase); Code: E; COG: COG0626.	0.960
metB	metE	SF4017	SF3907	Cystathionine gamma-synthase; Code: E; COG: COG0626.	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.974
metB	metH	SF4017	SF4085	Cystathionine gamma-synthase; Code: E; COG: COG0626.	B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Code: E; COG: COG1410.	0.976
metC	malY	SF3053	SF1647	Cystathionine beta-lyase (beta-cystathionase); Code: E; COG: COG0626.	Cystathionine beta-lyase; Code: E; COG: COG1168.	0.934
metC	metB	SF3053	SF4017	Cystathionine beta-lyase (beta-cystathionase); Code: E; COG: COG0626.	Cystathionine gamma-synthase; Code: E; COG: COG0626.	0.960
metC	metE	SF3053	SF3907	Cystathionine beta-lyase (beta-cystathionase); Code: E; COG: COG0626.	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.970
metC	metH	SF3053	SF4085	Cystathionine beta-lyase (beta-cystathionase); Code: E; COG: COG0626.	B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Code: E; COG: COG1410.	0.973
metE	malY	SF3907	SF1647	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	Cystathionine beta-lyase; Code: E; COG: COG1168.	0.901
metE	metB	SF3907	SF4017	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	Cystathionine gamma-synthase; Code: E; COG: COG0626.	0.974
metE	metC	SF3907	SF3053	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	Cystathionine beta-lyase (beta-cystathionase); Code: E; COG: COG0626.	0.970
metE	metG	SF3907	SF2179	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	Methionine tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.918
metE	metH	SF3907	SF4085	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Code: E; COG: COG1410.	0.993
metG	metE	SF2179	SF3907	Methionine tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	Tetrahydropteroyltriglutamate methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.918