STRINGSTRING
dnaE dnaE dnaQ dnaQ xseB xseB dnaX dnaX holA holA holB holB holE holE exoX exoX sbcB sbcB lig lig xseA xseA mutS mutS mutH mutH recJ recJ dam dam yicF yicF dnaN dnaN uvrD uvrD ssb ssb holC holC mutL mutL holD holD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaEDNA polymerase III, alpha subunit; Code: L; COG: COG0587. (1160 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (243 aa)
xseBExonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
dnaXDNA polymerase III, tau and gamma subunits; Code: L; COG: COG2812. (641 aa)
holADNA polymerase III, delta subunit; Code: L; COG: COG1466. (343 aa)
holBDNA polymerase III, delta prime subunit; Code: L; COG: COG0470. (334 aa)
holEDNA polymerase III, theta subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity). (76 aa)
exoXExodeoxyribonuclease X; Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788148 (219 aa). BLAST with identity of 99% in 219 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. (220 aa)
sbcBExonuclease I, 3 --> 5 specific; Code: L; COG: COG2925. (474 aa)
ligDNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (671 aa)
xseAExonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (456 aa)
mutSMethyl-directed mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (853 aa)
mutHMethyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. (229 aa)
recJSsDNA exonuclease RecJ; Similar to Escherichia coli K12 peptide chain release factor RF-2 gi: 2367172 (366 aa). BLAST with identity of 99% in 366 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. (577 aa)
damDNA adenine methylase; Code: L; COG: COG0338. (278 aa)
yicFPutative enzyme; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. (560 aa)
dnaNDNA polymerase III, beta-subunit; Code: L; COG: COG0592. (366 aa)
uvrDDNA-dependent ATPase I and helicase II; Code: L; COG: COG0210. (720 aa)
ssbssDNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (178 aa)
holCDNA polymerase III, chi subunit; Code: L; COG: COG2927. (147 aa)
mutLEnzyme in methyl-directed mismatch repair; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (615 aa)
holDDNA polymerase III, psi subunit; Code: L; COG: COG3050. (137 aa)
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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