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prtA prtA rpoS rpoS katG katG pelB pelB ousA ousA gyrB gyrB sbmC sbmC norV norV alkB alkB clpB clpB gyrA gyrA rpoH rpoH bcp bcp recN recN osmY osmY lexA lexA cel5Z cel5Z cpxP cpxP pelA pelA pelE pelE dinI dinI uvrB uvrB rpoE rpoE gst gst asr asr secE secE nhaA nhaA degP degP
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
prtASecreted protease A precursor; Protein involved in calcium ion binding, metallopeptidase activity, zinc ion binding, metalloendopeptidase activity, peptidase activity, modulation by symbiont of host protease activity, interaction with host via protein secreted by type II secretion system, proteolysis and protein catabolic process. (477 aa)
rpoSRNA polymerase, sigma S (sigma 38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
katGCatalase / Peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (660 aa)
pelBPectate lyase B; PelB is secreted by the Out secretion system; Protein involved in pectate lyase activity, polysaccharide catabolic process, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host and pathogenesis. (375 aa)
ousAProline/betaine transporter; Involved in uptake and accumulation of various osmoprotectants. Allows the uptake of glycine betaine, proline, ectoine, and pipecolic acid. May be a contributory factor in the infection progression within the host. (501 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (803 aa)
sbmCDNA gyrase inhibitory protein; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. (153 aa)
norVAnaerobic nitric oxide reductase flavorubredoxin; Protein involved in electron carrier activity, metal ion binding, FMN binding, oxidoreductase activity, hydrolase activity, xenobiotic metabolic process and (OBSOLETE) electron transport. (498 aa)
alkBProtein involved in DNA repair. (217 aa)
clpBClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (877 aa)
rpoHRNA polymerase, sigma 32 (sigma H) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (285 aa)
bcpThiol peroxidase, thioredoxin-dependent; Protein involved in antioxidant activity, oxidoreductase activity and xenobiotic metabolic process. (155 aa)
recNRecombination and repair protein; May be involved in recombinational repair of damaged DNA. (553 aa)
osmYProtein involved in response to osmotic stress. (218 aa)
lexADNA-binding transcriptional repressor of SOS regulon; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (203 aa)
cel5ZEndo-1,4-beta-glucanase precursor; Represents 97% of the global cellulase activity. (426 aa)
cpxPPutative exported protein precursor; Protein involved in transcription and xenobiotic metabolic process. (186 aa)
pelAPectate lyase, Pla; Involved in maceration and soft-rotting of plant tissue. (392 aa)
pelEPectate lyase pelE; Involved in maceration and soft-rotting of plant tissue. Pectate lyases have been implicated as pathogenicity factors which induce maceration or rotting of plant tissue. PelE is sufficient to induce these effects under laboratory conditions. (404 aa)
dinIProtein involved in DNA repair and SOS response. (80 aa)
uvrBExcinulease of nucleotide excision repair, DNA damage recognition component; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. I [...] (670 aa)
rpoERNA polymerase, sigma 24 (sigma E) factor; Protein involved in DNA binding, transcription factor activity, sigma factor activity, transcription, response to temperature stimulus, transcription initiation and regulation of transcription, DNA-dependent; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
gstGlutathionine S-transferase; Belongs to the GST superfamily. (204 aa)
asrAcid shock protein precursor; Protein involved in DNA binding, response to pH and nucleosome assembly. (194 aa)
secEPreprotein translocase membrane subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
nhaASodium-proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (398 aa)
degPSerine endoprotease (protease Do), membrane-associated; Protein involved in serine-type endopeptidase activity, protein binding, response to temperature stimulus and proteolysis; Belongs to the peptidase S1C family. (486 aa)
Your Current Organism:
Dickeya dadantii
NCBI taxonomy Id: 198628
Other names: D. dadantii 3937, Dickeya dadantii 3937, Dickeya dadantii str. 3937, Dickeya dadantii strain 3937, Erwinia chrysanthemi str. 3937, Pectobacterium chrysanthemi str. 3937
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